Results 21 to 30 of about 74,948 (336)

Skp2, the FoxO1 hunter [PDF]

Cancer Cell, 2005
Skp2 is an oncoprotein that mediates the degradation of several negative regulators of the cell cycle to promote cell proliferation. A recent report by Huang and colleagues reveals that Skp2 directs the ubiquitylation and subsequent degradation of FoxO1, a member of the FoxO family of transcription factors.
Dehan, Elinor, Pagano, Michele
openaire   +2 more sources

FOXO1 overexpression and loss of pSerine256-FOXO1 expression predicts clinical outcome in esophageal adenocarcinomas [PDF]

Scientific Reports, 2018
AbstractThe function of Forkhead box O 1 (FOXO1) and pSerine256-FOXO1 immunostaining in esophageal cancer is unclear. To clarify the prognostic role of nuclear FOXO1 and cytoplasmic pSerine256-FOXO1 immunostaining, a tissue microarray containing more than 600 esophageal cancers was analyzed.
Katharina Grupp, Faik G. Uzunoǧlu, Nathaniel Melling, Bianca T. Hofmann, Alexander T. El Gammal, Rainer Grotelüschen, Asmus Heumann, Eugen Bellon, Matthias Reeh, Gerrit Wolters‐Eisfeld, Tarik Ghabdan, Michael F. Nentwich, Kai Bachmann, Maximillian Bockhorn, Dean Bogoevski, Jakob R. Izbicki, Asad Kutup   +16 more
openalex   +3 more sources

Cancer-associated fibroblasts derived extracellular vesicles promote angiogenesis of colorectal adenocarcinoma cells through miR-135b-5p/FOXO1 axis

Cancer Biology & Therapy, 2022
Colorectal adenocarcinoma (COAD) is a prevalent malignant tumor. Cancer-associated fibroblasts (CAFs)-derived extracellular vesicles (EVs) (CAFs-EVs) are implicated in COAD treatment. This study explored the mechanism of CAFs-EVs in COAD. CAFs and normal
Xiaoyun Dai, Yangyang Xie, Mingjun Dong
semanticscholar   +1 more source

Kindlin-2 haploinsufficiency protects against fatty liver by targeting Foxo1 in mice

Nature Communications, 2022
Nonalcoholic fatty liver disease (NAFLD) affects a large population with incompletely defined mechanism(s). Here we report that Kindlin-2 is dramatically up-regulated in livers in obese mice and patients with NAFLD.
Huanqing Gao, Liang Zhou, Yiming Zhong, Z. Ding, Sixiong Lin, Xiao-Lan Hou, Xiaoqian Zhou, Jie Shao, Fan Yang, Xuenong Zou, Huiling Cao, G. Xiao   +11 more
semanticscholar   +1 more source

Pre-treatment with compound Danshen dripping pills prevents lipid infusion-induced microvascular dysfunction in mice

Pharmaceutical Biology, 2020
Context Recent studies have shown compound Danshen dripping pills (CDDP) could improve microcirculation in ischemic/reperfusion injury and other microvascular disorders. The mechanism for CDDP’s role in microcirculation is not clear. Objective To explore
Yanda Zhang, Jian Zhao, Ru Ding, Wenhao Niu, Zhiqing He, Chun Liang   +5 more
doaj   +1 more source

METTL14 aggravates endothelial inflammation and atherosclerosis by increasing FOXO1 N6-methyladeosine modifications

Theranostics, 2020
Aims: The N6-methyladenosine (m6A) modification plays an important role in various biological processes, but its role in atherosclerosis remains unknown.
D. Jian, Ying Wang, Liguo Jian, Hao Tang, Lixin Rao, Ke Chen, Z. Jia, Wanjun Zhang, Yiran Liu, Xu Chen, Xiwen Shen, Chuanyu Gao, Shuai Wang, Muwei Li   +13 more
semanticscholar   +1 more source

Myeloid FoxO1 depletion attenuates hepatic inflammation and prevents nonalcoholic steatohepatitis

Journal of Clinical Investigation, 2022
Hepatic inflammation is culpable for the evolution of asymptomatic steatosis to nonalcoholic steatohepatitis (NASH). Hepatic inflammation results from abnormal macrophage activation.
Sojin Lee, T. Usman, J. Yamauchi, Goma Chhetri, Xingchun Wang, G. Coudriet, Cuiling Zhu, Jingyang Gao, Riley McConnell, Kyler Krantz, D. Rajasundaram, Sucha Singh, J. Piganelli, A. Ostrowska, A. Soto‐Gutierrez, S. Monga, A. Singhi, R. Muzumdar, A. Tsung, H. H. Dong   +19 more
semanticscholar   +1 more source

Carpachromene Ameliorates Insulin Resistance in HepG2 Cells via Modulating IR/IRS1/PI3k/Akt/GSK3/FoxO1 Pathway

Molecules, 2021
Insulin resistance contributes to several disorders including type 2 diabetes and cardiovascular diseases. Carpachromene is a natural active compound that inhibits α-glucosidase enzyme.
Rania Alaaeldin, Iman A. M. Abdel-Rahman, H. Hassan, N. Youssef, Ahmed E. Allam, S. Abdelwahab, Qing‐Li Zhao, M. Fathy   +7 more
semanticscholar   +1 more source

Curcumin alleviates oxidative stress and inhibits apoptosis in diabetic cardiomyopathy via Sirt1‐Foxo1 and PI3K‐Akt signalling pathways

Journal of Cellular and Molecular Medicine, 2020
Diabetes is a disorder of glucose metabolism, and over 90% are type 2 diabetes. Diabetic cardiomyopathy (DCM) is one of the type 2 diabetes complications, usually accompanied by changes in myocardial structure and function, together with cardiomyocyte ...
Bincheng Ren, Yu-Fei Zhang, Shan-shan Liu, Xiao-jing Cheng, Xin Yang, X. Cui, Xinrui Zhao, Hui Zhao, Minfeng Hao, Mengdan Li, Yuanyuan Tie, Li Qu, Xueyi Li   +12 more
semanticscholar   +1 more source

Effects of phosphorylation sites of FoxO1 on protein synthesis and proteolysis in rat skeletal muscle cells exposure to hypoxia

Di-san junyi daxue xuebao, 2020
Objective To investigate the effects of different phosphorylation sites of FoxO1 on protein synthesis and proteolysis in rat skeletal muscle L6 cells under the condition of hypoxia.
JIA Jie, FU Pengyu, ZHU Rongxin, XU Chunyan2, GONG Lijing   +4 more
doaj   +1 more source