Results 41 to 50 of about 74,948 (336)

CD73 alleviates GSDMD‐mediated microglia pyroptosis in spinal cord injury through PI3K/AKT/Foxo1 signaling

Clinical and Translational Medicine, 2020
Background Neuroinflammation‐induced secondary injury is an important cause of sustained progression of spinal cord injury. Inflammatory programmed cell death pyroptosis executed by the pore‐forming protein gasdermin D (GSDMD) is an essential step of ...
Shun Xu, Jin Wang, Junjie Zhong, Minghao Shao, Jianyuan Jiang, Jian Song, Wei Zhu, Fan Zhang, Haocheng Xu, Guangyu Xu, Yuxuan Zhang, Xiaosheng Ma, Feizhou Lyu   +12 more
semanticscholar   +1 more source

Cold atmospheric plasmas target breast cancer stemness via modulating AQP3-19Y mediated AQP3-5K and FOXO1 K48-ubiquitination

International Journal on Biological Sciences, 2022
Cold atmospheric plasma (CAP) is selective against many cancers with little side effect, yet its molecular mechanism remains unclear. Through whole transcriptome sequencing followed by assays in vitro, in vivo and using clinical samples, we propose CAP ...
X. Dai, Dong-yan Cai, Peiyu Wang, Nan Nan, Lihui Yu, Zhifa Zhang, Renwu Zhou, D. Hua, Jianying Zhang, K. Ostrikov, Erik W. Thompson   +10 more
semanticscholar   +1 more source

Foxo1 and Foxo3 help Foxp3 [PDF]

Immunity, 2010
In this issue of Immunity, Kerdiles et al. (2010) report that Foxo transcription factors are essential for the development and function of Foxp3-expressing regulatory T (Treg) cells via controlling the expression of genes associated with Treg cell function.
Ohkura, Naganari, Sakaguchi, Shimon
openaire   +2 more sources

Insulin-like growth factor-1 is a negative modulator of glucagon secretion [PDF]

, 2017
Glucagon secretion involves a combination of paracrine, autocrine, hormonal, and autonomic neural mechanisms. Type 2 diabetes often presents impaired glucagon suppression by insulin and glucose.
Andreozzi, F, Di Fatta, C, Fuoco, A, Mancuso, E, Mannino, Gc, Sesti, G, Spiga, R   +6 more
core   +1 more source

Inhibition of Sodium-Glucose Cotransporter-2 during Serum Deprivation Increases Hepatic Gluconeogenesis via the AMPK/AKT/FOXO Signaling Pathway [PDF]

Endocrinology and Metabolism
Background Sodium-dependent glucose cotransporter 2 (SGLT2) mediates glucose reabsorption in the renal proximal tubules, and SGLT2 inhibitors are used as therapeutic agents for treating type 2 diabetes mellitus.
Jinmi Lee, Seok-Woo Hong, Min-Jeong Kim, Yu-Mi Lim, Sun Joon Moon, Hyemi Kwon, Se Eun Park, Eun-Jung Rhee, Won-Young Lee   +8 more
doaj   +1 more source

VE-cadherin and claudin-5: it takes two to tango [PDF]

, 2008
Endothelial barrier function requires the adhesive activity of VE-cadherin and claudin-5, which are key components of adherens and tight endothelial junctions, respectively.
A Taddei, AS Yap, D Hoogeboom, E Dejana, J Gavard, J Rhee, J. Silvio Gutkind, Julie Gavard, MAG Essers, MG Lampugnani, P Carmeliet, R Paul, S Tsukita, S van Wetering, S Weis, T Nitta, VV Orlova, WJ Nelson   +17 more
core   +5 more sources

The complex TIE between macrophages and angiogenesis [PDF]

, 2020
Macrophages are primarily known as phagocytic immune cells, but they also play a role in diverse processes, such as morphogenesis, homeostasis and regeneration.
Anghelina M., Avraham‐Davidi I., Baer C., Bailey A. S., Barnett F. H., Bonnardel J., Chakarov S., Chen L., Coffelt S. B., Corliss B. A., Cursiefen C., Daly C., Davies L. C., Davies L. C., De Palma M., De Palma M., De Palma M., De Palma M., De Palma M., De Spiegelaere W., DeFalco T., Deshmane S. L., Detry B., Dimova I., Dimova I., Eklund L., Elamaa H., Eubank T. D., Fantin A., Ferrari G., Fukuhara S., Ganta V. C., Ganta V. C., García S., Gerri C., Grunewald M., Guo L., Gurevich D. B., Hamm A., Hazan A. D., He H., Hoeffel G., Itoh M., Jetten N., Kim M., Kochhan E., Korhonen E. A., Korpelainen E. I., Krishnasamy K., Kumar A. H., Leibovich S. J., Lim H. Y., Liu C., Lucas T., Master Z., Metharom P., Michaeli S., Moldovan N. I., Moore E. M., Mueller S. B., Murdoch C., Murray P. J., Patel A. S., Polverini P. J., Potente M., Pucci F., Saharinen P., Saharinen P., Schif‐Zuck S., Schmeisser A., Seaman S. A., Seok S. H., Spiller K. L., Venneri M. A., Vestweber D., Webster N. L., West M. E. D., Willenborg S., Yamamoto S., Zajac E., Zenker D., Zhang W.   +81 more
core   +2 more sources

Effects of Insulin-Like Growth Factor-I on the Expression of Atrogin-1/MAFbx in Chick Myotube Cultures

The Journal of Poultry Science, 2017
The expression of atrogin-1/MAFbx, a muscle-specific E3 ubiquitin ligase, is increased in catabolic conditions that result in muscle atrophy. The expression of atrogin-1/MAFbx mRNA is also decreased by the insulin-like growth factor-I (IGF-I) in ...
Kazuki Nakashima, Aiko Ishida, Saki Shimamoto, Daichi Ijiri, Akira Ohtsuka   +4 more
doaj   +1 more source

The transcriptomic evolution of mammalian pregnancy:gene expression innovations in endometrial stromal fibroblasts [PDF]

, 2016
The endometrial stromal fibroblast (ESF) is a cell type present in the uterine lining of therian mammals. In the stem lineage of eutherian mammals, ESF acquired the ability to differentiate into decidual cells in order to allow embryo implantation.
Alyssa Birt, Arun R. Chavan, Deena Emera, Freyer, Günter P. Wagner, Hsieh-Li, Jamie Maziarz, Johnson, Koryu Kin, Laird, Manasi Kamat, Mess, Mihaela Pavlicev, Smith, Sreelakshmi Vasudevan, Troy L. Ott, Vincent J. Lynch   +16 more
core   +2 more sources

IGF2BP2 Induces U251 Glioblastoma Cell Chemoresistance by Inhibiting FOXO1-Mediated PID1 Expression Through Stabilizing lncRNA DANCR

Frontiers in Cell and Developmental Biology, 2022
Glioma is the most common type of malignant tumor of the nervous system and is characterized by high mortality and poor outcome. This study aims to investigate the mechanism underlying IGF2 mRNA-binding protein 2 (IGF2BP2) and long noncoding RNA DANCR in
Jun Han, Xiaojun Yu, Shanxi Wang, Ying-Guang Wang, Qikun Liu, Haoran Xu, Xiaosong Wang   +6 more
semanticscholar   +1 more source