Results 111 to 120 of about 159,335 (341)

Regulatory T cell‐derived interleukin‐15 promotes the diversity of immunological memory

European Journal of Immunology, Volume 53, Issue 1, January 2023., 2023
We investigated the identity of IL‐15 producing cells using several mouse strains with cell type‐specific loss of IL‐15 expression. After the resolution of acute infection, IL‐15 secreted by regulatory cells, but not skeletal muscles or myeloid cells, was required for the maintenance of a subset of memory cells referred to as terminal effector memory T
Alaa Madi, Jingxia Wu, Sicong Ma, Nina Weisshaar, Alessa Mieg, Marvin Hering, Yanan Ming, Ferdinand Zettl, Kerstin Mohr, Nora ten Bosch, Tilo Schlimbach, Franziska Hertel, Guoliang Cui   +12 more
wiley   +1 more source

High Fat Low Carbohydrate Diet Is Linked to CNS Autoimmunity Protection

Advanced Science, EarlyView.
Mapping global epidemiological data to macronutrient supply reveals high carbohydrate, in contrast to high fat supply, associates with increased multiple sclerosis (MS) prevalence and incidence. This is confirmed in a mouse MS model, experimental autoimmune encephalomyelitis (EAE), using isocaloric diets: a high carbohydrate diet aggravates, a high ...
Duan Ni, Jian Tan, Julen Reyes, Alistair M Senior, Caitlin Andrews, Jemma Taitz, Camille Potier‐Villette, Claire Wishart, Alanna Spiteri, Laura Piccio, Nicholas Jonathan Cole King, Romain Barrès, David Raubenheimer, Stephen James Simpson, Ralph Nanan, Laurence Macia   +15 more
wiley   +1 more source

Antigen targeting to dendritic cells: Still a place in future immunotherapy?

European Journal of Immunology, Volume 52, Issue 12, Page 1909-1924, December 2022., 2022
Dendritic cell‐based immunotherapy is a promising vaccination strategy to treat infectious diseases, autoimmunity, and cancer. In this review, we present an overview on the current state of antigen targeting approaches via C‐type lectin receptors, with an outlook on future developments and potential for clinical translation.
Patrizia Stoitzner, Nikolaus Romani, Christoph Rademacher, Hans Christian Probst, Karsten Mahnke   +4 more
wiley   +1 more source

Rorc restrains the potency of ST2+ regulatory T cells in ameliorating intestinal graft-versus-host disease [PDF]

, 2019
Soluble stimulation-2 (ST2) is increased during graft-versus-host disease (GVHD), while Tregs that express ST2 prevent GVHD through unknown mechanisms.
Blazar, Bruce R., Griesenauer, Brad, Hippen, Keli L., Liu, Hong, Loschi, Michael, Paczesny, Sophie, Ramadan, Abdulraouf, Reichenbach, Dawn K., Yang, Jinfeng, Zhang, Jilu   +9 more
core   +1 more source

Immune regulation and therapeutic application of T regulatory cells in liver diseases

Frontiers in Immunology
CD4+ CD25+ FOXP3+ T regulatory cells (Tregs) are a subset of the immunomodulatory cell population that can inhibit both innate and adaptive immunity by various regulatory mechanisms.
Ananya Ajith, Makram Merimi, Mandana Kazem Arki, Nikoo Hossein-khannazer, Mehdi Najar, Mehdi Najar, Massoud Vosough, Massoud Vosough, Etienne Marc Sokal, Mustapha Najimi   +9 more
doaj   +1 more source

Verteporfin‐Mediated In Situ Nanovaccine Based on Local Conventional‐Dose Hypofractionated Radiotherapy Enhances Antitumor and Immunomodulatory Effect

Advanced Science, EarlyView.
Here gelatinase‐responsive methoxypolyethyleneglycol–PVGLIG–polycaprolactone (mPEG–PVGLIG–PCL) nanoparticles’ loading verteporfin (N@VP) is developed, enhancing radiotherapy via X‐ray‐triggered singlet oxygen generation. Combined with 2 Gy (gray, a radiation dose unit) irradiation, N@VP achieves antitumor efficacy comparable to 8 Gy, and also promotes ...
Zhifan Zhang, Lin Li, Yuchen Ge, Anni Chen, Shanchao Diao, Yueling Yang, Qianyue Chen, Yingling Zhou, Jie Shao, Fanyan Meng, Lixia Yu, Manman Tian, Xiaoping Qian, Zhaoyu Lin, Chen Xie, Baorui Liu, Rutian Li   +16 more
wiley   +1 more source

Flt3L, LIF, and IL‐10 combination promotes the selective in vitro development of ESAMlow cDC2B from murine bone marrow

European Journal of Immunology, Volume 52, Issue 12, Page 1946-1960, December 2022., 2022
In vitro culture of murine bone marrow cells in Flt3L + LIF + IL‐10 promotes CD11b+ ESAMlow cDC2B subset generation from CDP but blocks cDC1 and pDC development. Flt3L alone or combined does not induce cDC2A generation in vitro. Abstract The development of two conventional dendritic cells (DC) subsets (cDC1 and cDC2) and the plasmacytoid DC (pDC) in ...
Laura Cyran, Julia Serfling, Luisa Kirschner, Hartmann Raifer, Michael Lohoff, Heike M. Hermanns, Andreas Kerstan, Jochen Bodem, Manfred B. Lutz   +8 more
wiley   +1 more source

Circulating Tumour Cells and FOXP3 in Regulatory T-Cells as New Modalities in Cancer Diagnosis and Metastasis Location Prediction

Acta Medica Indonesiana, 2023
Cancer is a complex group of diseases which arises from uncontrolled growth and spread of abnormal cells in the body. The pathophysiology of cancer involves a sequence of events at the cellular and molecular levels, often initiated by genetic mutations ...
Ikhwan Rinaldi
doaj  

EXPRESSION OF FoxP3 TRANSCRIPTION FACTOR IN BRONCHIAL ASTHMA

Медицинская иммунология, 2016
Forty-two patients with allergic bronchial asthma (ABA) forty persons with non-allergic bronchial asthma (NABA), and 47 healthy controls were involved into the study. Expression of FoxP3 mRNA was analyzed by RT-PCR. In patients with bronchial asthma (ABA
A. V. Eremeeva, L. N. Sorokina, V. N. Mineev, V. V. Lim, M. A. Nyoma, V. I. Trofimov   +5 more
doaj   +1 more source

Targeting Splenic Myeloid Cells with Nanobiologics to Prevent Postablative Pancreatic Cancer Recurrence via Inducing Antitumor Peripheral Trained Immunity

Advanced Science, EarlyView.
Using a preclinical pancreatic cancer model, we identified that tumor progression restructures splenic immunity via myeloid cell expansion. MDCa@RBC‐Alipo nanobiologics were engineered to epigenetically and metabolically reprogram splenic myeloid cells, alleviating post‐ablation immunosuppression.
Shengbo Wu, Weichen Xu, Xuexia Shan, Liping Sun, Shuo Liu, Xixi Sun, Shaoyue Li, Xiaodong Hou, Xiaowan Bo, Chengzhong Peng, Bin Huang, Huixiong Xu, Wenwen Yue   +12 more
wiley   +1 more source