Results 181 to 190 of about 106,447 (316)

Immunomodulatory Fibrous Scaffold with Dual Enzyme‐Mimic Activities Prevents Postsurgical Tumor Recurrence

Advanced Science, EarlyView.
A MnOx nanozyme‐functionalized electrospun fibrous scaffold is developed for postoperative therapy by leveraging its intrinsic physicochemical and immunomodulatory properties. Integrating POD‐ and CAT‐like activities, the scaffold induces immunogenic cell death, alleviates hypoxia, and reverses immunosuppression, while simultaneously recruiting and ...
Xiaoyi Zhao, Zhuolong Jiao, Yue Wang, Huimeng Gu, Longfei Li, Jian Song, Chen Xu, Jiajia Xue, Fu‐Jian Xu, Nana Zhao   +9 more
wiley   +1 more source

Correction: REV-ERB regulates RORγt+ regulatory T cell specification and function through the Bhlhe40-c-Maf axis. [PDF]

J Exp Med
Hu X, Liu Z, Li Y, You Y, Yue K, Liang Y, Loo CS, Yu J, Leblanc M, Wang D, Li H, Zheng Y.   +11 more
europepmc   +1 more source

Refractory Colitis Following Anti-CTLA4 Antibody Therapy: Analysis of Mucosal FOXP3+ T Cells

, 2009
James D. Lord, Robert C. Hackman, Amanda Moklebust, John A. Thompson, Celestia S. Higano, Deborah Chielens, Gideon Steinbach, George B. McDonald   +7 more
openalex   +2 more sources

Uncoupling of Proliferation and Cytokines From Suppression Within the CD4+CD25+Foxp3+ T–Cell Compartment in the 1st Year of Human Type 1 Diabetes [PDF]

, 2011
Angela Hughson, Irina Bromberg, Barbara Johnson, Sally A. Quataert, Nicholas Jospe, Deborah J. Fowell   +5 more
openalex   +1 more source

Supplementary Table 1 from Immune Suppression in Premalignant Respiratory Papillomas: Enriched Functional CD4⁺Foxp3⁺ Regulatory T Cells and PD-1/PD-L1/L2 Expression

, 2023
Lynda Hatam, James A. DeVoti, David Rosenthal, F. Lam, Allan L. Abramson, Bettie M. Steinberg, Vincent R. Bonagura   +6 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Pharmacological mechanisms of traditional Chinese medicine metabolites in regulating Treg cells: an integrative pathway review. [PDF]

Front Pharmacol
Wang C, Liao MJ, Wu Y, Lin H, Ye ZZ, Ma WZ, Yuan Q.   +6 more
europepmc   +1 more source

How Treg cells lose FOXP3 [PDF]

Nature Reviews Rheumatology, 2019
openaire   +2 more sources

CD4⁺CD25⁺Foxp3⁺Regulatory T Cells, Dendritic Cells, and Circulating Cytokines in Uncomplicated Malaria: Do Different Parasite Species Elicit Similar Host Responses?

, 2010
Raquel M. Gonçalves, K.C. Salmazi, Bianca A. N. Santos, Melissa S. Bastos, Sandra C. Rocha, Silvia Beatriz Boscardin, Ariel Mariano Silber, Esper G. Kallás, Marcelo U. Ferreira, Kézia Katiani Gorza Scopel   +9 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source