Results 201 to 210 of about 134,443 (312)

Extraintestinal Reprogramming of Colon‐Derived CD4+ Intraepithelial Lymphocytes Reveals a Mechanism Underlying the Gut–Joint Axis

Arthritis &Rheumatology, EarlyView.
Objective The gut–joint axis is a central paradigm in spondyloarthritis, yet the cellular mechanisms linking intestinal and joint immunity remain poorly understood. One potential link is T cell receptor αβ+ CD4+ colon intraepithelial lymphocytes (cIELs) that can traffic to extraintestinal tissues, including the joint.
Sarah M. Danielson, Connor Eck, Sucai Liu, Anna Helena Jonsson, Kristine A. Kuhn   +4 more
wiley   +1 more source

STAT6 Deficiency Accelerates DMBA/TPA-Induced Skin Papilloma Development and Is Associated with Regulatory T-Cell Accumulation and Reduced CD8+IFN-γ+ Responses. [PDF]

Biology (Basel)
Mejía-Muñoz A, Galindo-Santamaría T, Moreno-Tovar V, Salinas-Lara C, Sánchez-Garibay C, Arroyo Olarte RD, Leon-Cabrera S.   +6 more
europepmc   +1 more source

Synovial Tissue‐Guided Interleukin‐17A Inhibition for Refractory Arthritis in a Patient With Systemic Juvenile Idiopathic Arthritis

Arthritis &Rheumatology, Accepted Article.
Objective The objective of this study was to characterize the clinical, immunologic, and synovial tissue features of a patient with a systemic juvenile idiopathic arthritis (sJIA) who carries a novel heterozygous STAT5B loss‐of‐function variant (p.Gln139Ter) and whose arthritis responded markedly to interleukin‐17A (IL‐17A) inhibition.
Indira Sriram, Tomohiro Kawabe, Hitoshi Irabu, Mariana Correia Marques, Clara Lin, Alisa Gaskell, Jun Inamo, Michael R. Clay, Roselyn Fierkens, Robert C. Fuhlbrigge, Jeremy D. Prager, Norman R. Friedman, Sarah A. Gitomer, Michael J. Ombrello, Kentaro Yomogida   +14 more
wiley   +1 more source

TREM2⁺ macrophages mediate anticancer therapy-induced immune evasion in lung adenocarcinoma via the CCL5/CCL22-Treg axis. [PDF]

Front Immunol
Kim CY, Cha YJ, Park MK, Chang YS.
europepmc   +1 more source

Integrated spherical nucleic acid nanoreactor mobilizes targeted PD‐L1 proteolysis and cuproptosis for robust breast cancer immunotherapy

BMEMat, EarlyView.
This study provides an integrated spherical nucleic acid nanoreactor (denoted as AMCuD) for targeted PD‐L1 degradation and chemo‐dynamically enhanced cuproptosis to synergically elicit robust immunotherapy against the triple‐negative breast cancer (TNBC) growth, recurrence and metastasis.
Ningxi Li, Honglin Huang, Qianyi Zeng, Li Zeng, Ziman Yang, Jinyang Shen, Shun Li, Hong Yang, Yiyao Liu, Chunhui Wu   +9 more
wiley   +1 more source

Inducible cAMP Early Repressor Limits Glycolytic Programming in Regulatory T Cells and Supports Control of Inflammatory Colitis. [PDF]

Eur J Immunol
Lopez Krol A, Silva L, Nascimento DC, Oberwalder SM, Chawla H, de Carvalho GAB, Boukhallouk F, Romero M, Hausen A, Gaida MM, Berod L, Alves-Filho JC, Sparwasser T.   +12 more
europepmc   +1 more source

Programmable three‐state nanoreactor for spatiotemporally controlled tumor therapy

BMEMat, EarlyView.
The OMVs are shielded with a biocompatible Da–Ca shell, which prolongs its circulation period and promotes intratumoral accumulation. Importantly, the biocompatible Da–Ca shell can be controllably disintegrated in tumor microenvironment by using laser irradiation, generating in situ hyperthermia and releasing Ca2+.
Guihong Lu, Peng Ye, Xiaoyan Li, Ke Ma, Chengliang Lyu, Kai Zhang, Ran Luo, Yang Ji, Shiqi Mei, Fan Zhang, Jinxie Zhang, Lin Mei, Hui Tan   +12 more
wiley   +1 more source

IL-2-producing T_FH cells sustain T_reg cell homeostasis and immune tolerance in the gut. [PDF]

Nat Immunol
Dave S, Bachus H, Santiago N, Meloun A, Smelkinson M, Foote JB, Hill T, Fucile C, Rosenberg AF, Ballesteros-Tato A.   +9 more
europepmc   +1 more source

From pathogen to “living drug factory” innovative strategies and clinical translation of bacteria as programmable intelligent vectors for cancer therapy

BMEMat, EarlyView.
Engineered bacteria serve as smart, living therapeutics that target tumors, deliver drugs, and remodel immunosuppressive microenvironments. This review highlights their potential to potentiate immunotherapy, radiotherapy, and chemotherapy, offering a promising paradigm for precise and synergistic cancer treatment. Abstract The dynamic interplay between
Haonan Shen, Weichen Zhang, Gaoli Niu, Li Wang, Ruiyan Li, Yueyue Fan, Feixue Lu, Lingling Xu, Xiaoyuan Ji, Yong Kang   +9 more
wiley   +1 more source

Immunophenotypic Features of T-Lymphocyte Distribution Across Histological and Molecular Subtypes of Serous Ovarian Neoplasms: A Retrospective Immunohistochemical Study. [PDF]

Biomedicines
Demyashkin G, Dorfman S, Asaturova A, Rogozhina A, Badlaeva A, Holdeenko V, Shchekin V, Kulchenko N, Kononenko T, Vadyukhin M, Amirov N, Borovaya T, Shegai P, Kaprin A.   +13 more
europepmc   +1 more source