Results 211 to 220 of about 168,700 (307)

MiR-200c restoration inhibits FOXP3 and metastatic spread in breast cancer: evidence from in vitro and in vivo models. [PDF]

BMC Cancer
El-Khazragy N, Alsolami A, Aref AM, Hassan MNM, Othman MS.   +4 more
europepmc   +1 more source

Age‐related clinical heterogeneity and peripheral T cell profile alterations in primary Sjögren's disease: A retrospective study of 5778 patients

Rheumatology &Autoimmunity, EarlyView.
This large‐scale retrospective study of 5778 primary Sjögren's disease (SjD) patients, stratified by diagnostic age, defines a distinct clinical and immunological profile for early‐diagnosed (<45 years) disease. We identified early diagnosis as an independent risk factor for hypergammaglobulinemia and interstitial lung disease, underpinned by a ...
Yuan Ning, Ruiling Feng, Kai Zhang, Yipeng Han, Ruoyi Wang, Guangwen Li, Yuebo Jin, Jing He   +7 more
wiley   +1 more source

The evolving role of regulatory T cells in Sjögren's disease pathogenesis and the promise of Treg‐based therapies: A comprehensive review

Rheumatology &Autoimmunity, EarlyView.
Graphical Abstract The evolving role of regulatory T cells in primary Sjögren's disease pathogenesis and the promise of Treg‐based therapies. Abstract Sjögren's disease (SjD) is a chronic systemic autoimmune disorder characterised by exocrine gland dysfunction and diverse systemic manifestations.
Gagan Urs, Bharath Raj Srinivasan, Himabindu Jayaprakash Narayan, Mirunalini Gobinath, Lekitha Manjunath, Mahabaleshwar Mamadapur   +5 more
wiley   +1 more source

Enrichment of <i>Candida</i> associated with dysbiosis contributes to mucosal CD4⁺FOXP3⁺ regulatory T cell accrual and their dysfunction in aging. [PDF]

Front Immunol
Jayaraman S, Mahalingam SS, Zhu Z, Faddoul F, Paes da Silva A, Asaad R, Bhaskaran N, Schneider E, Taylor T, Horne S, Yoo A, Zhang L, Burgener A, Pandiyan P.   +13 more
europepmc   +1 more source

Inulin‐Butyrate Nanogel for Modulation of Gut Microbiome, Intestinal Barrier, and Regulatory T‐Cells in Colitis

Small, EarlyView.
IBD is driven by a vicious cycle of dysbiosis, barrier dysfunction, and immune dysregulation. We developed an inulin–butyrate conjugate nanogel (IBN) that accumulates in inflamed colon and releases butyrate via microbial inulinase/esterase. The inulin shell remodels the microbiome, while localized butyrate strengthens barrier integrity and promotes ...
Nayoon Park, Bom Lee, Hyeon‐Jeong Jeon, Ji Yeon Kim, Suyeon Park, Seong‐Eun Kim, Dong‐Kyu Lee, Yonghyun Lee   +7 more
wiley   +1 more source

Timosaponin AIII enhances CAR-T cell potency and prevents relapse through impairing CAR-Tregs. [PDF]

Nat Commun
Hou M, Zhang W, Qi Z, Li G, Mei H, Qi S, Jin R, Zhao Y, Tang X, Xiu B, Chen X, Zhao Y, Hu C, Qian C, Li X, Xu Z, Chen Y, Wu C, Wang B, Yan L, Li D, Huang Y, Liang R, Wang A, Liu J, Wang W, Li B, Long J, Li P, Liang A, Liu Q, Yang J.   +31 more
europepmc   +1 more source

Tumor cell membrane camouflaged liposomal pharmaceuticals for cascade catalysis‐driven redox modulation and synergistic ROS/RNS antitumor therapy

VIEW, EarlyView.
A tumor cell membrane camouflaged liposomal nanoplatform (C‐MLip@LA) modulates tumor redox homeostasis to enhance targeted therapy. By encapsulating L‐arginine, anchoring MnO2 nanoparticles, and leveraging homologous membrane‐mediated specificity, C‐MLip@LA efficiently triggers a synergistic ROS/RNS cascade, amplifies immunogenic cell death, and ...
Guangrong Zheng, Tengfei Ke, Hongjin Wang, Hong Huang, Ying Zhang, Guanghai Fei, Chengde Liao, Haiyan Yang   +7 more
wiley   +1 more source

Editorial: The transcriptional and metabolic role of Foxp3 in regulatory T cells. [PDF]

Front Immunol
Benamar M.
europepmc   +1 more source

Enhancement of immune checkpoint inhibitor efficacy by DHX58+ SELL+ T cells in advanced gastric cancer

VIEW, EarlyView.
We created a coculture system using patient‐derived organoids (PDOs) and tumor‐infiltrating lymphocytes (TILs) that mimics important interactions between PDOs and TILs in the presence of various ICIs. Our findings reveal that CD62L+ T cells, activated by CD44+ cancer stem cells (CSCs), facilitate tumor regression in samples sensitive to ICIs, which is ...
Jie Chen, Youdong Liu, Hongda Pan, Tianyi Cai, Mingde Zang, Xiaowen Liu, Ziwen Long, Xin Fan, Jun Lu, Fenglin Liu   +9 more
wiley   +1 more source

ASO-based PKM splice-switching therapy increases anti-CTLA-4 antibody efficacy in pancreatic ductal adenocarcinoma. [PDF]

Cell Discov
Han L, Gan L, Schäfer B, Voss DM, Danielsen M, Kostov O, Liu J, Wang T, Caruthers MH, Chen H, Krainer AR.   +10 more
europepmc   +1 more source