Results 211 to 220 of about 134,443 (312)

Beyond antimicrobials: Ecological nano‐strategies for rebalancing dysbiotic oral microbial homeostasis

BMEMat, EarlyView.
Oral microbial homeostasis, a dynamic host‐microbe balance, is vital in infectious diseases. Conventional antibiotics often disrupt this homeostasis, spurring interest in nanomaterials for oral microbial homeostasis rebalancing. This review outlines nanomaterial strategies across three ecological levels (population/community, ecosystem, and cross ...
Chen Hu, Aohan Luan, Yujun Yang, Linlin Wang, Huilin Wang, Ning Wang, Guixin He, Yajie Yang, Rabiya Noor, Jawad Hussain, Longquan Shao   +10 more
wiley   +1 more source

Age-associated differences in the breast cancer immune microenvironment. [PDF]

J Pathol Clin Res
Humlevik RO, Chen Y, Klingen TA, Sæle AK, Svanøe AA, Hugaas U, Kvamme AB, Tegnander AF, Winge I, Aas T, Heie A, Akslen LA, Wik E, Hoivik EA.   +13 more
europepmc   +1 more source

Engineered immunostimulatory H2O2‐producing microreactors driven by yeast as localized living cancer therapeutics

BMEMat, EarlyView.
Engineered yeast microreactors that produce H2O2 within tumors enable selective cancer cell killing while releasing immunostimulatory components, effectively suppressing local tumor growth and activating systemic antitumor immunity, with further efficacy enhanced by anti‐PD‐1 therapy and transarterial embolization.
Wenqian He, Chunjie Wang, Minming Chen, Weihao Yang, Bin Yu, Yuhang Hu, Hengze Ding, Yifan Yan, Zhijuan Yang, Liangzhu Feng   +9 more
wiley   +1 more source

Establishment of pediatric reference ranges for circulating naïve and memory T and B cell subsets guided by the human immunophenotyping consortium standardization initiative: A large, single center U.S. experience

Cytometry Part B: Clinical Cytometry, EarlyView.
Abstract Our knowledge of the immune system continues to expand at a rapid pace, and this coupled with technological advances now enables us to interrogate both the breadth and the depth of the immune response at levels without precedent. This has also facilitated rapidly integrating some of this carefully vetted knowledge into clinical practice ...
Aaruni Khanolkar, Aisha Ahmed
wiley   +1 more source

Cancer stem cell programs S-nitrosylation and deubiquitination of FoxP3 protein to promote regulatory T cell differentiation. [PDF]

Front Immunol
Liu X, Lei J, Jiang X, Li L, Yu L, Wang G, Guo K, Wen Z, Wang Y.   +8 more
europepmc   +1 more source

Transforming Growth Factor‐β (TGF‐β)–Dependent Iron Homeostasis and Altered TGF‐β Responsiveness in FLVCR1‐Deficient CD4 T Cells

Barrier Immunity, EarlyView.
Negative feedback resulting from continuous TGFβRI expression in FLVCR1‐deficient CD4 T cells. Unlike in normal CD4 T cells, TGF‐βRI is not degraded upon activation in FLVCR1‐deficient CD4 T cells. Sustained receptor expression results in increased TGF‐β, leading to dysregulated iron homeostasis, impaired cell proliferation, and enhanced cell death ...
Amber L. Siglin, Zelong Han, Afia Nkansah, Cheong‐Hee Chang   +3 more
wiley   +1 more source

CXCR4-dependent migratory differences between peripheral Tregs and Tcons preserve GVL while limiting GVHD after HSCT. [PDF]

Blood Adv
Ruggeri L, Pierini A, Urbani E, Ciardelli S, Del Sordo R, Sola R, Zei T, Iacucci Ostini R, Saldi S, Adamo FM, Mancusi A, Jardini KE, Hoxha E, Viglione V, Sembenico R, Zorutti F, Hui S, Di Ianni M, Falzetti F, Martelli MP, Mecucci C, Aristei C, Carotti A, Martelli MF, Velardi A.   +24 more
europepmc   +1 more source

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Targeting FOXP3 and Regulatory T Cells in Systemic Lupus Erythematosus: Emerging Therapeutic Strategies and Clinical Prospects. [PDF]

J Cell Biochem
Du S, Xu W, Zhao L, Shi X, Liu R.
europepmc   +1 more source