Results 231 to 240 of about 134,443 (312)

Mapping the immune microenvironment of <i>KIT</i>- and <i>PDGFRA</i>-mutant GISTs reveals genotype-specific immune infiltration and TKI-induced remodeling. [PDF]

Front Immunol
Costa A, Nigro MC, Grillini M, Gozzellino L, Nannini M, Motta I, De Leo A, Pirini MG, Del Gaudio M, Ravaioli M, Ianni M, Pasquinelli G, Astolfi A, Pantaleo MA.   +13 more
europepmc   +1 more source

FOXP3 Stability-Adaptation Paradox: Reshaping Treg-Based Therapies for Intestinal Diseases. [PDF]

Int J Biol Sci
Ren Y, Liu X, Wang B, Yin H, Zhao J, Xin S, Wang H, Zhang Y, Liu X, Liu J, Hua R, Tian X, Bian Y, Gu S, Zhang H, Wei T, Gao L, Lu X, Shang H, Gao H, Xu J.   +20 more
europepmc   +1 more source

Dehydrocostus Lactone Suppresses Hepatocellular Carcinoma by Inhibiting Protein Tyrosine Kinase‐7 Mediated β‐Catenin Signaling

Phytotherapy Research, EarlyView.
Schematic summary of the experimentally supported mechanism of DHL in hepatocellular carcinoma. Dehydrocostus lactone (DHL), a sesquiterpene lactone derived from Aucklandia lappa, directly engages protein tyrosine kinase 7 (PTK7), as supported by molecular docking, CETSA, and DARTS assays.
Xiwen Fan, Junhui Li, Yu Qiao, Yuwen Zhong, Xuecheng Ge, Yaoshuai Zhang, Zishu Wang, Feng Qian, Weixin Ren   +8 more
wiley   +1 more source

Association of regulatory B, T cells and cytokine production with disease stage in non-small cell lung cancer patients: prospective case control study. [PDF]

BMC Cancer
Hetta HF, Zahran AM, Nabil EE, Elkady AA, Goda AM, Soliman TM, Elkady A, Esmaeel HM, Algammal AM, Mohamed NA, ElBadre HM, Alrefai H, Elyamany A, Alkady OA.   +13 more
europepmc   +1 more source

Melittin Reprograms Tumor‐Associated Macrophages Through CD18‐Mediated Immunomodulation

Phytotherapy Research, EarlyView.
Melittin selectively targets CD18 to deplete M2‐TAMs and remodel the TME to suppress tumor growth. ABSTRACT Tumor‐associated macrophages (TAMs), particularly the M2‐like subtype, contribute to an immunosuppressive tumor microenvironment and promote tumor progression.
Ik‐Hwan Han, Hyunju Lee, Eunbin Ko, Ilseob Choi, Soyoung Kim, Deok‐Sang Hwang, Hyunsu Bae   +6 more
wiley   +1 more source

Functional Heterogeneity of <i>Fusobacterium nucleatum</i> Subspecies in the Immune Microenvironment of Oral Squamous Cell Carcinoma. [PDF]

Microorganisms
Yano M, Kamiya T, Yamamoto Y, Kouga T, Oishi M, Nishio M, Suzuki A, Sunami K, Ohtani N.   +8 more
europepmc   +1 more source

Pharmacokinetic and Pharmacodynamic Interactions Between Anti‐Asthma Drugs and Medicinal Plants: A Comprehensive Review

Phytotherapy Research, EarlyView.
ABSTRACT Asthma affects 260–300 million people worldwide. About 20%–35% of patients use medicinal plants with their asthma medication, often without telling their clinicians. Disclosure rates are low; up to 42% of asthma outpatients use herbal products, with no records in their charts.
Emine Kocyigit, Aylin Bülbül, Betul Kocaadam‐Bozkurt, Osman Bozkurt, Duygu Ağagündüz, Raffaele Capasso   +5 more
wiley   +1 more source