Results 241 to 250 of about 168,700 (307)

Infection control in the brain and the eye

Acta Ophthalmologica, EarlyView.
Abstract The Central Nervous System (CNS), comprising the brain and the eye, is considered to have a ‘privileged’ mechanism for dealing with immunological challenge (immune privilege, IP). CNS IP has been revealed through experiments using foreign protein antigens and cell and tissue alloantigens (grafts), but evidence for a role for IP in modulating ...
John V. Forrester, Paul G. McMenamin, Samantha J. Dando   +2 more
wiley   +1 more source

MAP4K2 suppresses antitumor immunity in a pancreatic cancer model by promoting Treg differentiation. [PDF]

J Clin Invest
Chuang HC, Wang CW, Hsueh CH, Xiao YZ, Tsai CY, Hsu PM, Tan EL, Chiu HY, Tan TH.   +8 more
europepmc   +1 more source

The Role of Inflammation in Infant Colic—A Systematic Review and Meta‐Analysis

Acta Paediatrica, EarlyView.
ABSTRACT Aim Despite being a self‐limiting condition, infant colic is associated with negative consequences for caregivers and infants. Gut inflammation is hypothesised as a contributing factor. We collected and meta‐analysed the most recent evidence on the association between infant colic and gut inflammation.
Dan Boëtius Andersen, Julius Fog, Marie V. Vestergaard, Ida Scheel Rasmussen, Philip Wilson, Gritt Overbeck, Louise Bidstrup Jørgensen, Jakob Kragstrup, Betina Hebbelstrup Jensen   +8 more
wiley   +1 more source

TGF-β signaling mediates crosstalk between CD8⁺ T cells and CD39⁺ induced Treg cells in autoimmune inflammation. [PDF]

J Biomed Sci
Chen Y, Dang JL, Long Q, Zang N, Liu L, Lu Y, Zhao W, Liang RZ, Yang Y, Zhao J, Chen JR, Xiong YD, Wang J, Pan YF, Olsen N, Zheng SG.   +15 more
europepmc   +1 more source

MicroRNAs as potential architects of immune dysregulation and megakaryocytic failure in immune thrombocytopenia

British Journal of Haematology, EarlyView.
Summary Immune thrombocytopenia (ITP) is a complex autoimmune disorder characterized by accelerated destruction of peripheral platelets and impaired megakaryopoiesis. While the cellular effectors, dysregulated T cells, hyperactive B cells and phagocytic macrophages are well characterized, the upstream epigenetic mechanisms orchestrating this ...
Zhenyu Liu, Johan Rebetz, Lamya Garabet, Waleed Ghanima, Peipei Xu, Hans Wadenvik, Drew Provan, Rick Kapur, John W. Semple   +8 more
wiley   +1 more source

Cisplatin Promotes Immunosuppression in Ovarian Cancer by Enhancing miR-181a-5p-Enriched Extracellular Vesicles to Drive Regulatory T Cell Differentiation. [PDF]

J Extracell Vesicles
Zheng L, Mu S, Liu M, Lei P, Zhang J, Dai Y, He C, Qu F, Tan W.   +8 more
europepmc   +1 more source

High frequency of CD95+/CD45RA− regulatory T cells defines an immunosuppressive profile associated with MDS progression

British Journal of Haematology, EarlyView.
Summary Dynamic interactions between mutated haematopoietic cells and immune cells are key drivers of myelodysplastic neoplasms (MDS) initiation and progression. Regulatory T cells (Tregs) are central mediators of immunosuppression in MDS. We thus aimed to characterize Treg subpopulations in the bone marrow (BM) of MDS patients and to explore their ...
Romain Vazquez, Nicolas Deredec, Ismael Boussaid, Pierre Boncoeur, Camille Knosp, Amandine Houvert, Loria Zalmai, Chloe Friedrich, Carole Almire, Charles Dussiau, Lise Willems, Rudy Birsen, Justine Decroocq, Didier Bouscary, Olivier Kosmider, Shahram Kordasti, Michaela Fontenay, Yannick Simoni, Nicolas Chapuis   +18 more
wiley   +1 more source

MR-Guided Laser Interstitial Thermal Therapy for Recurrent Glioblastoma: A Case Report With Novel Insights Into Histopathological Changes and Immunological Responses. [PDF]

Neuropathol Appl Neurobiol
Nielsen SH, Artzi SB, Skjøth-Rasmussen J, Larsen CC, Hammouda NM, Larsen KB, Rasmussen R, Hansen AE, Kristensen BW.   +8 more
europepmc   +1 more source

Integrated proteomic and metabolomic profiling reveals sex‐stratified biomarkers predicting chronicity in paediatric primary immune thrombocytopenia

British Journal of Haematology, EarlyView.
Construction of the immune thrombocytopenia (ITP) chronicity prediction model was based on sex‐stratified multi‐omics analysis, identifying key sex‐specific predictors (intercellular adhesion molecule‐1 [ICAM‐1] and biopterin in males; actin, alpha 2, smooth muscle, aorta [ACTA‐2] and N6‐acetyl‐L‐lysine in females).
Yuanyuan Xue, Rongrong Zhang, Dongmei Liang, Yupeng Xu, Zhaofang Tian, Xiaohong Dai, Wei Xu, Qingqing Cao, Haiyan Zhu, Yun Wang, Yufang Yuan   +10 more
wiley   +1 more source

From Development to Aging: Dynamic Roles of the Thymic Medulla in T Cell Biology. [PDF]

Immunol Rev
Michalaki C, Sharjeel M, Cowan JE.
europepmc   +1 more source