Results 241 to 250 of about 134,443 (312)

Thirty years in, regulatory T cells are ready for medicine. [PDF]

Front Immunol
Kawakami R, Jain A.
europepmc   +1 more source

Treg‐stromal cell axis in tissue repair and autoimmune diseases: Mechanisms and clinical translation

Rheumatology &Autoimmunity, EarlyView.
The Treg‐stromal cell axis as a central regulator of tissue repair and immune tolerance. Under physiological conditions, bidirectional communication between Tregs and stromal cells—mediated by cell‐surface molecular contacts, anti‐inflammatory cytokines, and extracellular vesicles—orchestrates inflammation resolution, immune tolerance, and complete ...
Peiyan Zhang, Rongyuan Gao, Zhaohui Zheng   +2 more
wiley   +1 more source

DGKα and ζ deficiency causes regulatory T-cell dysregulation, destabilization, and conversion to pathogenic T-follicular helper cells to trigger IgG1-predominant autoimmunity. [PDF]

Elife
Li L, Huang H, Wang H, Pan Y, Tao H, Zhang S, Karmaus P, Fessler MB, Sleasman J, Zhong XP.   +9 more
europepmc   +1 more source

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

A photoimmune synergizing RNA interference technology for highly effective antitumor treatment

Smart Molecules, EarlyView.
We developed a red‐light‐activated small‐molecule photosensitizer FNBS, which enables simultaneous photodynamic immunotherapy and RNA interference. FNBS can induce pyroptosis, immunogenic cell death and RNA degradation, avoiding the carrier‐dependent delivery drawbacks of conventional RNAi therapy, converting cold tumors into hot tumors and ...
Xiang Xia, Bingbing Wu, Xueze Zhao, Wen Sun, Jianjun Du, Jiangli Fan, Xiaojun Peng   +6 more
wiley   +1 more source

Glutamine-dependent biosynthetic pathways fuel autoreactive T and B cells in Foxp3 deficiency-mediated disease. [PDF]

JCI Insight
Zafar MA, Hill Machado CN, Behera J, Zhong Y, Li X, Joshi S, El Fazaa Y, Camacho V, Georgiev P, Kurmi K, Haigis M, Charbonnier LM.   +11 more
europepmc   +1 more source

Harnessing the nonthermal effects of ultrasound for cancer treatment: From mechanisms to applications

Smart Molecules, EarlyView.
Nonthermal ultrasound transforms acoustic energy into diverse therapeutic bioeffects through cavitation, mechanical stimulation, and physicochemical activation. This review discusses how acoustic parameters, biological mechanisms, and responsive materials interact to influence nonthermal ultrasound‐enabled cancer therapies. Mechanism‐guided engineering
Liu Wang, Huan Tang, Yue Pan, Mingle Li, Weijie Zhao, Kai Liu   +5 more
wiley   +1 more source

Profiling tumor immune microenvironment of epithelial ovarian carcinoma. [PDF]

Oncoimmunology
Dehghani-Ghobadi Z, Dionellis VS, Traber C, Moore JS, Samartzis N, Ryser S, Kalaitzopoulos DR, Liaudet N, Ferreira C, Du Bois V, Stancl P, Karlic R, Choschzick M, Noske A, Sandoval JL, Samartzis EP, Labidi-Galy I.   +16 more
europepmc   +1 more source