Results 161 to 170 of about 122,949 (273)

Rewiring Antitumor Immunity: Targeting CLDN18.2 with Conditional 4-1BB Activation. [PDF]

Clin Cancer Res
Pretelli G, Garralda E.
europepmc   +1 more source

Antigen‐binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones

Heather A. Bruce, A.U. Singer, Levi L. Blazer, Khanh Luu, Lynda Ploder, Alevtina Pavlenco, Igor Kurinov, Jarrett Adams, Sachdev S. Sidhu   +8 more
openalex   +2 more sources

Hepatitis E Virus ORF1 Polyprotein Harbors a Pocket‐Like Cavity That Is Vital for Virus Replication and Represents a Novel Antiviral Target

Advanced Science, EarlyView.
Within the hepatitis E virus (HEV) ORF1 polyprotein, the X domain interacts with viral RNA‐dependent RNA polymerase (RdRp), forming a functional “pocket‐like” cavity (PC) that is crucial for viral replication. Structure‐based screening, surface plasmon resonance (SPR) assays, and HEV model validation collectively identify saikosaponin D and ...
Xiaohui Ding, Dou Zeng, Dan Liu, Yingying Bian, Bin Li, Zheng Li, Qiudi Li, Shiquan Liang, Yunlong Si, Qili Yao, Yibo Ding, Jiahui Zhu, Xiangyang Li, Kuiyang Zheng, Hongbo Guo, Wenshi Wang   +15 more
wiley   +1 more source

Correction: The Evolution of Anti‑CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function. [PDF]

CNS Drugs
Cree BAC, Berger JR, Greenberg B.
europepmc   +1 more source

Structural and Functional Versatility of the Amyloidogenic Non‐Amidated Variant of the Antimicrobial Peptide Citropin 1.3

Advanced Science, EarlyView.
Citropin 1.3 is an antimicrobial peptide derived from amphibians that forms amyloid structures. Here, the structural and functional properties of citropin 1.3 are characterized. Using high‐resolution imaging approaches, a variety of canonical and undescribed fibril morphologies are identified.
Fabio Strati, Mariana Pigozzi Cali, Yehudi Bloch, Siavash Mostafavi, Jim Monistrol, Aleksandr Golubev, Bader Rayan, Emil Gustavsson, Meytal Landau   +8 more
wiley   +1 more source

From Acute Carditis, Rheumatic Carditis, and Morphologic Cardiac Reactions to Allergic Angina, Allergic Myocardial Infarction, and Kounis Syndrome: A Multidisciplinary and Multisystem Disease. [PDF]

J Cardiovasc Dev Dis
Kounis NG, Stefanidis A, Hung MY, Özkan U, de Gregorio C, Ceasovschih A, Mplani V, Gogos C, Assimakopoulos SF, Chatzigrigoriadis C, Plotas P, Dousdampanis P, Kouni SN, Tsigkas G, Patsouras N, Calogiuri G, Pourmasumi S, Koniari I.   +17 more
europepmc   +1 more source

Single-domain antibodies for brain targeting [PDF]

, 2014
Lalatsa, Katerina, Moreira Leite, Diana
core   +1 more source

Free‐Standing Halogen‐Bonded Nanosheets Formed by Ultrasonic Liquid Exfoliation

Advanced Science, EarlyView.
Free‐standing nanosheets held together by halogen bonding interactions (XB), formed through ultrasonic liquid exfoliation of layered molecular crystals, are reported here for the first time. The work challenges the conventional requirement for strong in‐layer interactions for the formation of stable nanosheets through liquid exfoliation and establishes
Prioti Choudhury Purba, Elisa Marelli, Thomas M. Roseveare, Joshua Nicks, Lee Brammer, Nicholas G. White, Natalia Martsinovich, Giuseppe Resnati, Pierangelo Metrangolo, Jonathan A. Foster   +9 more
wiley   +1 more source

The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4 + and CD8 + tumor-infiltrating lymphocytes. [PDF]

Anticancer Drugs
Reader CS, Liao W, Potter-Landua BJ, Veyssier CS, Seal CJ, Brewis N, Morrow M.   +6 more
europepmc   +1 more source

Polysaccharide Adjuvants as Innate Immune Trainers: Bridging Pattern Recognition Receptor (PRR) Activation and Metabolic Reprogramming for Synthetic Vaccine Design

Advanced Science, EarlyView.
Polysaccharides modulate immune responses by engaging pattern recognition receptors (PRRs) to induce T‐cell activation. In vaccine design, their particle size critically influences lymph node targeting and activation mechanisms. By engineering structural complexity and multivalent PRR engagement, polysaccharides enable precise modulation of immune ...
Jeong Hyun Moon, May Thazin Phoo, Yubin Kim, Jinsung Ahn, April Kim, Jutaek Nam, Soo‐Hong Lee, James J. Moon, Sejin Son   +8 more
wiley   +1 more source