Results 161 to 170 of about 121,391 (276)

Hydrogen‐Deuterium Exchange Mass Spectrometry for Molecular Glue Characterization

Advanced Science, EarlyView.
Molecular glues that stabilize protein–protein interactions are challenging to identify. Here, hydrogen‐deuterium exchange mass spectrometry can show and reveal gluing mechanisms that vary between protein binding partners. Abstract Molecular glues are powerful bioactive molecules that stabilize protein–protein interactions.
Danielle F. Kay, Hadeeqa G. Raza, Richard G. Doveston, Aneika C. Leney   +3 more
wiley   +1 more source

Biocompatible Mesoporous Materials for Bone Therapy

Advanced Science, EarlyView.
Biocompatible mesoporous materials (BMMs), characterized by high specific surface area, tunable pore size, different shapes and structures, and multidimensional functionalized modifications, have revolutionary applications in treating bone‐related diseases.
Biao Yu, Yan Wu, Yang Hong, Peng Wang, Xiaowen Liu, Yonghui Deng, Jiacan Su   +6 more
wiley   +1 more source

Artificial Internalizing Receptors for Targeted Degradation of Extracellular Proteins

Advanced Science, EarlyView.
Small organic molecules that are anchored into the lipid bilayer of a mammalian cell and have an exofacial recognition ligand can act as artificial internalizing receptors. These receptors are an efficacious tool to selectively capture and internalize cognate antibodies from the extracellular environment in a protein‐specific manner.
Ane B. Søgaard, Rikke Fabech Hansson, Mikkel Høj Nielsen, Alexander N. Zelikin   +3 more
wiley   +1 more source

Graphene‐Inspired Mono‐Elemental 2D Materials: Synthesis, Properties, and Potential Applications of Xenes

Advanced Science, EarlyView.
This review summarizes the recent advances in mono‐elemental 2D materials, or Xenes, including their synthesis strategies, theoretical guidance, and stability challenges. It highlights emerging approaches such as deep learning‐assisted design with encapsulation techniques and heterostructure for scalable production and practical applications in ...
Yufan Yang, Yuqin Xiao, Qingxin Zhang, Yuxin Yan, Tao Wu, Cheng Heng Pang   +5 more
wiley   +1 more source

Correction: The Evolution of Anti‑CD20 Treatment for Multiple Sclerosis: Optimization of Antibody Characteristics and Function. [PDF]

CNS Drugs
Cree BAC, Berger JR, Greenberg B.
europepmc   +1 more source

Antigen‐binding fragments with improved crystal lattice packing and enhanced conformational flexibility at the elbow region as crystallization chaperones

Heather A. Bruce, A.U. Singer, Levi L. Blazer, Khanh Luu, Lynda Ploder, Alevtina Pavlenco, Igor Kurinov, Jarrett Adams, Sachdev S. Sidhu   +8 more
openalex   +2 more sources

Limpet‐Inspired Multifunctional Composite Fibers with Exceptional Mechanical Performance From Self‐Assembled Aramid Nanofibers

Advanced Science, EarlyView.
Inspired by the architecture of limpet teeth, composite fibers formed via self‐assembled aramid nanofibers and in situ iron mineralization achieve exceptional mechanical performance and multifunctionality, surpassing many natural and synthetic benchmarks.
Tiantian Ren, Shouhua Feng, Ming Yang
wiley   +1 more source

The tetravalent, bispecific properties of FS118, an anti-LAG-3/PD-L1 antibody, mediate LAG-3 shedding from CD4 + and CD8 + tumor-infiltrating lymphocytes. [PDF]

Anticancer Drugs
Reader CS, Liao W, Potter-Landua BJ, Veyssier CS, Seal CJ, Brewis N, Morrow M.   +6 more
europepmc   +1 more source

Repositioning Antimicrobial Peptides Against WHO‐Priority Fungi

Advanced Science, EarlyView.
The growing burden of drug‐resistant fungal infections, driven by pathogens such as Candida auris, Cryptococcus neoformans, and Aspergillus fumigatus, underscores the urgent need for novel antifungal therapies. This review explores antimicrobial peptides as promising agents with membrane‐disruptive activity, immunomodulatory properties, and delivery ...
Cesar Augusto Roque‐Borda, Kaila Petronila Medina‐Alarcón, João Paulo Soler Gonçalves Pereira, Thais Cristina dos Anjos Sevilhano, Brigitte Aguilar‐Morón, Fernando Díaz‐Cárdenas, Lucas Silva da Cruz, Francisco Humberto Xavier‐Júnior, Eduardo Festozo Vicente, João Perdigão, Beatriz G. de la Torre, Fernando Albericio, Fernando Rogério Pavan   +12 more
wiley   +1 more source

Editorial: Safety consideration in the development of anti-tumor monoclonal antibodies during drug development. [PDF]

Front Oncol
Wang T, Abedin SE, van der Laan JW.
europepmc   +1 more source