Results 11 to 20 of about 7,556 (242)
The therapeutic potential of sialylated Fc domains of human IgG
mAbs, 2021 Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
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Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody
Scientific Reports, 2022 The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics.
Ramakrishnan Natesan, Neeraj J. Agrawal
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Pharmaceuticals, 2021 We previously reported a new polymer, lactic-co-glycolic acid-polyethylenimine (LGA-PEI), as an improved nanoparticle (NP) delivery for therapeutic nucleic acids (TNAs).
Jian-Ming Lü +5 more
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Frontiers in Immunology, 2021 The function of antibodies, namely the identification and neutralization of pathogens, is mediated by their antigen binding site (Fab). In contrast, the subsequent signal transduction for activation of the immune system is mediated by the fragment ...
Kristina Zlatina, Sebastian P. Galuska
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PLoS ONE, 2021 Mycobacterium tuberculosis (Mtb) infects one-quarter of the world's population. Mtb and HIV coinfections enhance the comorbidity of tuberculosis (TB) and AIDS, accounting for one-third of all AIDS-associated mortalities.
Hui-Chen Chang Foreman +2 more
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Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. [PDF]
PLoS ONE, 2015 Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies
Michael R Kierny +4 more
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, 2010 Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut +4 more
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Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]
, 2017 INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K. +2 more
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Immunoglobulin G fragment crystallizable glycosylation after hematopoietic stem cell transplantation is dissimilar to donor profiles [PDF]
, 2018 Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
de Haan, N. (Noortje) +4 more
core +3 more sources
Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome
Acta Materia Medica, 2023 A significant proportion of patients who survive coronavirus disease of 2019 (COVID-19) develop a constellation of life-altering symptoms that persist long after the initial infection has resolved.
Sandra E. Reznik +2 more
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