Results 11 to 20 of about 121,391 (276)

Determination of variable region sequences from hybridoma immunoglobulins that target Mycobacterium tuberculosis virulence factors.

PLoS ONE, 2021
Mycobacterium tuberculosis (Mtb) infects one-quarter of the world's population. Mtb and HIV coinfections enhance the comorbidity of tuberculosis (TB) and AIDS, accounting for one-third of all AIDS-associated mortalities.
Hui-Chen Chang Foreman, Andrew Frank, Timothy T Stedman   +2 more
doaj   +2 more sources

Impact of LS Mutation on Pharmacokinetics of Preventive HIV Broadly Neutralizing Monoclonal Antibodies: A Cross-Protocol Analysis of 16 Clinical Trials in People without HIV

Pharmaceutics
Monoclonal antibodies are commonly engineered with an introduction of Met428Leu and Asn434Ser, known as the LS mutation, in the fragment crystallizable region to improve pharmacokinetic profiles.
Bryan T. Mayer, Lily Zhang, Allan C. deCamp, Chenchen Yu, Alicia Sato, Heather Angier, Kelly E. Seaton, Nicole Yates, Julie E. Ledgerwood, Kenneth Mayer, Marina Caskey, Michel Nussenzweig, Kathryn Stephenson, Boris Julg, Dan H. Barouch, Magdalena E. Sobieszczyk, Srilatha Edupuganti, Colleen F. Kelley, M. Juliana McElrath, Huub C. Gelderblom, Michael Pensiero, Adrian McDermott, Lucio Gama, Richard A. Koup, Peter B. Gilbert, Myron S. Cohen, Lawrence Corey, Ollivier Hyrien, Georgia D. Tomaras, Yunda Huang   +29 more
doaj   +2 more sources

The N-Glycosylation of Mouse Immunoglobulin G (IgG)-Fragment Crystallizable Differs Between IgG Subclasses and Strains

Frontiers in Immunology, 2017
N-linked glycosylation of the fragment crystallizable (Fc)-region of immunoglobulin G (IgG) is known to have a large influence on the activity of the antibody, an effect reported to be IgG subclass specific. This situation applies both to humans and mice.
Noortje de Haan, Karli R. Reiding, Jasminka Krištić, Agnes L. Hipgrave Ederveen, Gordan Lauc, Manfred Wuhrer   +5 more
doaj   +2 more sources

The Neonatal Fc Receptor (FcRn): A Misnomer?

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +2 more sources

Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus

Emerging Microbes and Infections
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions.
Zuning Ren, Mengjun Li, Jiayin Chen, Xiaohua Gong, Shuo Song, Delin Li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao, Jie Peng, Yang Yang, Chenguang Shen   +19 more
doaj   +2 more sources

PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor

Nature Communications
Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to increase of LDL cholesterol in blood. Its blockers have emerged as promising therapeutics for cardiovascular diseases.
Dasom Shin, Soungchan Kim, Hwan Lee, Hyun-Chae Lee, Jaewon Lee, Hyun-woo Park, Mina Fukai, EunByule Choi, Subin Choi, Bon-Jun Koo, Ji-Hoon Yu, Gyurae No, Sungyoon Cho, Chan Woo Kim, Dohyun Han, Hyun-Duk Jang, Hyo-Soo Kim   +16 more
doaj   +2 more sources

Tafasitamab for the treatment of patients with diffuse large B-cell lymphoma

Human Vaccines & Immunotherapeutics
Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) require additional treatments, especially those not eligible or not responding to high dose cytotoxic chemotherapy and stem cell transplantation.
Maria Cristina Pirosa, Anastasios Stathis, Emanuele Zucca   +2 more
doaj   +2 more sources

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Nature Communications
IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to Fcɣ receptors ...
Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes   +8 more
doaj   +2 more sources

Local Immune Activation and Age Impact on Humoral Immunity in Mice, with a Focus on IgG Sialylation

Vaccines
Age alters the host’s susceptibility to immune induction. Humoral immunity with circulating antibodies, particularly immunoglobulin G (IgG), plays an essential role in immune response.
Priti Gupta, Tibor Sághy, Miriam Bollmann, Tao Jin, Claes Ohlsson, Hans Carlsten, Carmen Corciulo, Cecilia Engdahl   +7 more
doaj   +2 more sources

Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

The Journal of Clinical Investigation
The function of the spike protein N terminal domain (NTD) in coronavirus (CoV) infections is poorly understood. However, some rare antibodies that target the SARS-CoV-2 NTD potently neutralize the virus.
Naveenchandra Suryadevara, Nurgun Kose, Sandhya Bangaru, Elad Binshtein, Jennifer Munt, David R. Martinez, Alexandra Schäfer, Luke Myers, Trevor D. Scobey, Robert H. Carnahan, Andrew B. Ward, Ralph S. Baric, James E. Crowe Jr   +12 more
doaj   +2 more sources