Results 11 to 20 of about 122,949 (273)

Identification of mpox M1R and B6R monoclonal and bispecific antibodies that efficiently neutralize authentic mpox virus

Emerging Microbes and Infections
In 2022, the monkeypox virus (mpox virus, MPXV) exhibited global dissemination across six continents, representing a notable challenge owing to the scarcity of targeted antiviral interventions.
Zuning Ren, Mengjun Li, Jiayin Chen, Xiaohua Gong, Shuo Song, Delin Li, Minghui Yang, Jianhai Yu, Sadia Asghar, Yanxin Cui, Shiyu Niu, Zhonghui Liao, Yushan Jiang, Jiahui Liu, Yuqing Li, Bao Zhang, Wei Zhao, Jie Peng, Yang Yang, Chenguang Shen   +19 more
doaj   +2 more sources

The Neonatal Fc Receptor (FcRn): A Misnomer?

Frontiers in Immunology, 2019
Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik, Kine M. K. Sand, Kine M. K. Sand, Jonathan J. Hubbard, Jonathan J. Hubbard, Jan Terje Andersen, Jan Terje Andersen, Inger Sandlie, Richard S. Blumberg, Richard S. Blumberg   +9 more
doaj   +2 more sources

Tafasitamab for the treatment of patients with diffuse large B-cell lymphoma

Human Vaccines & Immunotherapeutics
Patients with relapsed or refractory (R/R) diffuse large B-cell lymphoma (DLBCL) require additional treatments, especially those not eligible or not responding to high dose cytotoxic chemotherapy and stem cell transplantation.
Maria Cristina Pirosa, Anastasios Stathis, Emanuele Zucca   +2 more
doaj   +2 more sources

Pre-Clinical Studies of a Novel Bispecific Fusion Protein Targeting C3b and VEGF in Neovascular and Nonexudative AMD Models. [PDF]

Ophthalmol Ther
KNP-301 is a bi-specific fragment crystallizable region (Fc) fusion protein, which inhibits both C3b and vascular endothelial growth factor (VEGF) simultaneously for patients with late-stage age-related macular degeneration (AMD).
Lee Y, Kim D, Chung PED, Lee M, Kim N, Chang J, Lee BC.   +6 more
europepmc   +2 more sources

N-linked Fc glycosylation is not required for IgG-B-cell receptor function in a GC-derived B-cell line

Nature Communications
IgG secreted by B cells carry asparagine N(297)-linked glycans in the fragment crystallizable (Fc) region. Changes in Fc glycosylation are related to health or disease and are functionally relevant, as IgG without Fc glycans cannot bind to Fcɣ receptors ...
Theresa Kissel, Veerle F. A. M. Derksen, Arthur E. H. Bentlage, Carolien Koeleman, Lise Hafkenscheid, Diane van der Woude, Manfred Wuhrer, Gestur Vidarsson, René E. M. Toes   +8 more
doaj   +2 more sources

IGLV3-21^R110-directed bispecific antibodies activate T cells and promote killing in a high-risk subset of chronic lymphocytic leukemia

Haematologica
We previously used a disease-specific B cell receptor (BCR) point mutation (IGLV3-21R110) for selective targeting of a high-risk subset of chronic lymphocytic leukemia (CLL) with chimeric antigen receptor (CAR) T cells.
Claudia Fischer, Shih-Shih Chen, Johanna Nimmerfroh, Anne Eugster, Simon Stücheli, Christoph Schultheiß, Corinne Widmer, Dominik Heim, Benjamin Kasenda, Jakob Passweg, Sebastian Kobold, Lukas Egli, Nicolò Coianiz, Obinna Chijioke, Nicholas Chiorazzi, Marie Follo, Heinz Läubli, Matthias Peipp, Mascha Binder   +18 more
doaj   +2 more sources

Rapid In Vivo Screening of Monoclonal Antibody Cocktails Using Hydrodynamic Delivery of DNA-Encoded Modified Antibodies [PDF]

Biomedicines
Background: Monoclonal antibodies (mAbs) are potent treatment options for infectious diseases. The rapid isolation and in vivo validation of therapeutic mAb candidates, including mAb cocktails, are essential to combat novel or rapidly mutating pathogens.
Hugues Fausther-Bovendo, George (Giorgi) Babuadze, Teodora Ivanciuc, Birte Kalveram, Yue Qu, Jihae Choi, Allison McGeer, Mario Ostrowski, Samira Mubareka, Ami Patel, Roberto P. Garofalo, Robert Kozak, Gary P. Kobinger   +12 more
doaj   +2 more sources

Structural characterization of human monoclonal antibodies targeting uncommon antigenic sites on spike glycoprotein of SARS-CoV

The Journal of Clinical Investigation
The function of the spike protein N terminal domain (NTD) in coronavirus (CoV) infections is poorly understood. However, some rare antibodies that target the SARS-CoV-2 NTD potently neutralize the virus.
Naveenchandra Suryadevara, Nurgun Kose, Sandhya Bangaru, Elad Binshtein, Jennifer Munt, David R. Martinez, Alexandra Schäfer, Luke Myers, Trevor D. Scobey, Robert H. Carnahan, Andrew B. Ward, Ralph S. Baric, James E. Crowe Jr   +12 more
doaj   +2 more sources

Development of a Novel Electrochemical Immunosensor for Rapid and Sensitive Detection of Sesame Allergens Ses i 4 and Ses i 5

Foods
Due to their lipophilicity and low content, the major sesame oleosin allergens, Ses i 4 and Ses i 5, are challenging to identify using conventional techniques.
Huimei Li, Tian’ge Pan, Shudong He, Hanju Sun, Xiaodong Cao, Yongkang Ye   +5 more
doaj   +2 more sources

Bivalent circular RNA vaccines against porcine epidemic diarrhea virus and transmissible gastroenteritis virus

Frontiers in Immunology
Porcine Epidemic Diarrhea Virus (PEDV) and Transmissible Gastroenteritis Virus (TGEV) pose significant threats to neonatal piglets, leading to severe diarrhea and potentially lethal consequences.
Weibing Zhang, Weibing Zhang, Lei Wang, Lei Wang, Liyu Chu, Xu Ma, Xu Ma, Wenjing Gao, Wenjing Gao, Yarong Wu, Yongfeng Qiao, Yongfeng Qiao, Xianjun Wang, Xianjun Wang, Lu Zhao, Lu Zhao, Hong Hu, Hong Hu, Xiaoyu Li, Ding Zhang, Tao Song, Guocan Yu, Haidong Wang, Chunbo Dong, Chunbo Dong, Zhida Liu, Zhida Liu   +26 more
doaj   +2 more sources