Results 21 to 30 of about 122,949 (273)

Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions

Nature Biomedical Engineering, 2022
Short half-lives in circulation and poor transport across the blood–brain barrier limit the utility of cytokines and growth factors acting as receptor agonists.
Katsuya Sakai, Nozomi Sugano-Nakamura, E. Mihara, N. Rojas-Chaverra, Sayako Watanabe, Hiroki Sato, R. Imamura, D. Voon, Itsuki Sakai, C. Yamasaki, C. Tateno, Mikihiro Shibata, H. Suga, J. Takagi, Kunio Matsumoto   +14 more
semanticscholar   +1 more source

Enhancement of SARS-CoV-2 Infection via Crosslinking of Adjacent Spike Proteins by N-Terminal Domain-Targeting Antibodies

Viruses, 2023
The entry of SARS-CoV-2 into host cells is mediated by the interaction between the spike receptor-binding domain (RBD) and host angiotensin-converting enzyme 2 (ACE2).
Tina Lusiany, Tohru Terada, Jun-ichi Kishikawa, Mika Hirose, David Virya Chen, Fuminori Sugihara, Hendra Saputra Ismanto, Floris J. van Eerden, Songling Li, Takayuki Kato, Hisashi Arase, Matsuura Yoshiharu, Masato Okada, Daron M. Standley   +13 more
doaj   +1 more source

In vivo pharmacokinetic enhancement of monomeric Fc and monovalent bispecific designs through structural guidance

Communications Biology, 2021
Lu Shan et al. present a structure-guided approach to engineer a monovalent form of the fragment crystallizable (Fc) region of an IgG4 antibody to adapt multiple versions of half-life extension modifications and bispecific targeting.
Lu Shan, Nydia Van Dyk, Nantaporn Haskins, Kimberly M. Cook, Kim L. Rosenthal, Ronit Mazor, Sonia Dragulin-Otto, Yu Jiang, Herren Wu, William F. Dall’Acqua, Martin J. Borrok, Melissa M. Damschroder, Vaheh Oganesyan   +12 more
doaj   +1 more source

The therapeutic potential of sialylated Fc domains of human IgG

mAbs, 2021
Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
doaj   +1 more source

Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody

Scientific Reports, 2022
The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics.
Ramakrishnan Natesan, Neeraj J. Agrawal
doaj   +1 more source

Characterization and validation of a middle-down hydrophobic interaction chromatography method to monitor methionine oxidation in IgG1

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) can impact the efficacy of a drug. Methionine oxidation can alter the overall hydrophobicity of an antibody, thereby inducing conformational changes and affecting its ...
Somar Khalil, Nisha Patel, Francoise Bevillard-Kumar, Cyrille Chéry, William Burkitt, John O’Hara, Annick Gervais   +6 more
doaj   +1 more source

Modified Therapeutic Antibodies: Improving Efficacy

Engineering, 2021
The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections.
Ji-Min Dai, Xue-Qin Zhang, Jing-Yao Dai, Xiang-Min Yang, Zhi-Nan Chen   +4 more
doaj   +1 more source

Two Antibody-Guided Lactic-co-Glycolic Acid-Polyethylenimine (LGA-PEI) Nanoparticle Delivery Systems for Therapeutic Nucleic Acids

Pharmaceuticals, 2021
We previously reported a new polymer, lactic-co-glycolic acid-polyethylenimine (LGA-PEI), as an improved nanoparticle (NP) delivery for therapeutic nucleic acids (TNAs).
Jian-Ming Lü, Zhengdong Liang, Dongliang Liu, Bin Zhan, Qizhi Yao, Changyi Chen   +5 more
doaj   +1 more source

Immunoglobulin Glycosylation – An Unexploited Potential for Immunomodulatory Strategies in Farm Animals

Frontiers in Immunology, 2021
The function of antibodies, namely the identification and neutralization of pathogens, is mediated by their antigen binding site (Fab). In contrast, the subsequent signal transduction for activation of the immune system is mediated by the fragment ...
Kristina Zlatina, Sebastian P. Galuska
doaj   +1 more source

Efgartigimod: A First-in-class Investigational Antibody Fragment for the Treatment of Generalized Myasthenia Gravis

US Neurology, 2022
Myasthenia gravis (MG) is a rare autoimmune disorder characterized by fatigue and muscle weakness. About 85–90% of patients with generalized MG display pathogenic immunoglobulin (Ig)G antibodies against the skeletal muscle nicotinic acetylcholine ...
F. Vanoli, R. Mantegazza
semanticscholar   +1 more source