Results 21 to 30 of about 121,391 (276)
FoodsDue to their lipophilicity and low content, the major sesame oleosin allergens, Ses i 4 and Ses i 5, are challenging to identify using conventional techniques.
Huimei Li +5 more
doaj +2 more sources
The therapeutic potential of sialylated Fc domains of human IgG
mAbs, 2021 Pathogens frequently use multivalent binding to sialic acid to infect cells or to modulate immunity through interactions with human sialic acid-binding immunoglobulin-type lectins (Siglecs).
Richard J. Pleass
doaj +1 more source
Non-covalent Fc-Fab interactions significantly alter internal dynamics of an IgG1 antibody
Scientific Reports, 2022 The fragment-antigen-binding arms (Fab1 and Fab2) in a canonical immunoglobulin G (IgG) molecule have identical sequences and hence are always expected to exhibit symmetric conformations and dynamics.
Ramakrishnan Natesan, Neeraj J. Agrawal
doaj +1 more source
Journal of Pharmaceutical and Biomedical Analysis Open, 2023 Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) can impact the efficacy of a drug. Methionine oxidation can alter the overall hydrophobicity of an antibody, thereby inducing conformational changes and affecting its ...
Somar Khalil +6 more
doaj +1 more source
Modified Therapeutic Antibodies: Improving Efficacy
Engineering, 2021 The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers, inflammatory disorders, and refractory infections.
Ji-Min Dai +4 more
doaj +1 more source
Pharmaceuticals, 2021 We previously reported a new polymer, lactic-co-glycolic acid-polyethylenimine (LGA-PEI), as an improved nanoparticle (NP) delivery for therapeutic nucleic acids (TNAs).
Jian-Ming Lü +5 more
doaj +1 more source
Frontiers in Immunology, 2021 The function of antibodies, namely the identification and neutralization of pathogens, is mediated by their antigen binding site (Fab). In contrast, the subsequent signal transduction for activation of the immune system is mediated by the fragment ...
Kristina Zlatina, Sebastian P. Galuska
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US Neurology, 2022 Myasthenia gravis (MG) is a rare autoimmune disorder characterized by fatigue and muscle weakness. About 85–90% of patients with generalized MG display pathogenic immunoglobulin (Ig)G antibodies against the skeletal muscle nicotinic acetylcholine ...
F. Vanoli, R. Mantegazza
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 The amplification of weak transient protein–protein interactions to elicit robust immune responses is a recurring theme in immune processes (1) (Fig. 1).
Paul R. Sargunas, Jamie B. Spangler
semanticscholar +1 more source
Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy
Engineering, 2023 Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear.
Huifang Wu +13 more
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