Results 21 to 30 of about 7,556 (242)

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production [PDF]

, 2017
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies
Battella, Simone, Belardinilli, Francesca, Capuano, Cristina, Galandrini, Ricciarda, Giannini, Giuseppe, Molfetta, Rosa, Palmieri, Gabriella, Paolini, Rossella, Pighi, Chiara, Santoni, Angela   +9 more
core   +2 more sources

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Lasso-grafted designer cytokines [PDF]

, 2022
Cytokine receptor agonists can be designed with longer half-lives in circulation and with enhanced penetration of the blood-brain barrier by genetically grafting macrocyclic peptides into the structural loops of fragment crystallizable ...
Bernhagen, Jurgen, Kapurniotu, Aphrodite
core   +1 more source

Spinodal-assisted crystallization in polymer melts [PDF]

, 1998
Recent experiments in some polymer melts quenched below the melting temperature have reported spinodal kinetics in small-angle x-ray scattering before the emergence of a crystalline structure.
A. J. Ryan, G. Goldbeck-Wood, G. Strobl, I. I. Frenkel, J. Brandrup, J. D. Gunton, J. D. McCoy, J. W. Cahn, J. W. Martin, K. Kawasaki, L. D. Landau, L. R. Pratt, M. Cakmak, M. Dettenmaier, M. Imai, M. Imai, M. R. L. Evans, N. J. Terrill, N. J. Terrill, P. D. Olmsted, P. J. Flory, P. R. ten Wolde, S. Alexander, S. Harrington, T. A. Ezquerra, T. C. B. McLeish, T. Dehoff, T. Kanaya, W. C. K. Poon, W. C. K. Poon, W. C. K. Poon   +30 more
core   +2 more sources

FFAS server: novel features and applications. [PDF]

, 2011
The Fold and Function Assignment System (FFAS) server [Jaroszewski et al. (2005) FFAS03: a server for profile-profile sequence alignments. Nucleic Acids Research, 33, W284-W288] implements the algorithm for protein profile-profile alignment introduced ...
Cai, Xiao-hui, Godzik, Adam, Jaroszewski, Lukasz, Li, Zhanwen, Weber, Christoph   +4 more
core   +3 more sources

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

Frontiers in Cell and Developmental Biology, 2020
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Gordan Lauc, Marija Pezer, Falk Nimmerjahn   +6 more
doaj   +1 more source

Current Advances in γδ T Cell-Based Tumor Immunotherapy [PDF]

, 2017
γδ T cells are a minor population (~5%) of CD3 T cells in the peripheral blood, but abound in other anatomic sites such as the intestine or the skin.
Cocorullo, Gianfranco, Dieli, Francesco, Gulotta, Eliana, Gulotta, Gaspare, LO PRESTI, Elena, Meraviglia, Serena, Pizzolato, Gabriele   +6 more
core   +1 more source

Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Frontiers in Plant Science, 2022
The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh, Advaita Acarya Singh, Priyen Pillay, Previn Naicker, Kabamba Alexandre, Kanyane Malatji, Lukas Mach, Herta Steinkellner, Juan Vorster, Rachel Chikwamba, Tsepo L. Tsekoa   +10 more
doaj   +1 more source

Preclinical efficacy of hK2 targeted [177Lu]hu11B6 for prostate cancer theranostics [PDF]

, 2019
Androgen ablating drugs increase life expectancy in men with metastatic prostate cancer, but resistance inevitably develops. In a majority of these recurrent tumors, the androgen axis is reactivated in the form of increased androgen receptor (AR ...
Beattie, Bradley J., Beattie, Kai A., Elgqvist, Jörgen, Eriksson, Sophie E., Larsson, Erik, Strand, Sven-Erik, Thorek, Daniel L. J., Timmermand, Oskar Vilhelmsson, Tran, Thuy A., Ulmert, David, Örbom, Anders   +10 more
core   +2 more sources

Characterization and validation of a middle-down hydrophobic interaction chromatography method to monitor methionine oxidation in IgG1

Journal of Pharmaceutical and Biomedical Analysis Open, 2023
Post-translational modifications (PTMs) of therapeutic monoclonal antibodies (mAbs) can impact the efficacy of a drug. Methionine oxidation can alter the overall hydrophobicity of an antibody, thereby inducing conformational changes and affecting its ...
Somar Khalil, Nisha Patel, Francoise Bevillard-Kumar, Cyrille Chéry, William Burkitt, John O’Hara, Annick Gervais   +6 more
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