Results 31 to 40 of about 121,391 (276)

Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. [PDF]

PLoS ONE, 2015
Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies
Michael R Kierny, Thomas D Cunningham, Rachida A Bouhenni, Deepak P Edward, Brian K Kay   +4 more
doaj   +1 more source

Of bits and bugs [PDF]

, 2010
Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut, Kostrewa, Dirk, Niessing, Dierk, Roche, Stéphane, Söding, Johannes   +4 more
core   +1 more source

Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]

, 2017
INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K., Mantravadi, Santhi, Ogdie, Alexis   +2 more
core   +2 more sources

Next generation Fc scaffold for multispecific antibodies

iScience, 2021
Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes, Athena Sudom, Danyang Gong, Douglas A. Whittington, Vivian Li, Christopher Mohr, Danqing Li, Timothy P. Riley, Stone D.-H. Shi, Jun Zhang, Fernando Garces, Zhulun Wang   +11 more
doaj   +1 more source

Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome

Acta Materia Medica, 2023
A significant proportion of patients who survive coronavirus disease of 2019 (COVID-19) develop a constellation of life-altering symptoms that persist long after the initial infection has resolved.
Sandra E. Reznik, Amit K. Tiwari, Charles R. Ashby   +2 more
doaj   +1 more source

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

Immunoglobulin G fragment crystallizable glycosylation after hematopoietic stem cell transplantation is dissimilar to donor profiles [PDF]

, 2018
Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
de Haan, N. (Noortje), Driessen, G.J.A. (Gertjan), Lankester, A.C. (Arjan), Tol, M.J.D. (Marie-José) van, Wuhrer, M. (Manfred)   +4 more
core   +3 more sources

A Comparison of Immunoglobulin Variable Region N-Linked Glycosylation in Healthy Donors, Autoimmune Disease and Lymphoma

Frontiers in Immunology, 2020
N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
E. Vletter, Marvyn T. Koning, H. Scherer, H. Veelken, R. Toes   +4 more
semanticscholar   +1 more source

High-level fed-batch fermentative expression of an engineered Staphylococcal protein A based ligand in E. coli: purification and characterization [PDF]

, 2015
The major platform for high level recombinant protein production is based on genetically modified microorganisms like Escherichia coli (E. coli) due to its short dividing time, ability to use inexpensive substrates and additionally, its genetics is ...
Fernández Lahore, Marcelo, Gorrepati, Kanaka Durga Devi, Grasselli, Mariano, Kangwa, Martin, Polat, Ayse Nur, Yelemane, Vikas   +5 more
core   +1 more source

Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. [PDF]

, 2017
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life.
Abdiche, Abourawi, Abu-Raya, Amirthalingam, Amirthalingam, Antohe, Atwell, Bainbridge, Bakchoul, Baker, Baker, Basha, Bialas, Bondt, Brair, Brambell, Brambell, Brambell, Bruhns, Calderon, Calvert, Cavalcante, Chen, Chu, Cumberland, Dabrera, Dashivets, de Moraes-Pinto, de Souza, Dillon, Einarsdottir, Einarsdottir, Ellinger, Ellinger, Englund, Faucette, Faucette, Firan, Fowden, França, Fu, Gaither, Gall, Goldfarb, Griffiths, Hamilton, Hammes, Hanson, Hartter, Hashira, Heath, Heidl, Henkle, Heron, Holder, Holland, Hornby, Huhn, Jansen, Jauniaux, Jefferis, Jones, Junghans, Kennedy, Kibe, Kim, Kim, Kim, Kohler, Kristoffersen, Ladhani, Leach, Leitner, Li, Li, Lightle, Madhi, Maertens, Malek, Malek, Mammaro, Martin, Martins, Mathiesen, Mathiesen, Medesan, Mestas, Mimura, Mitchell, Mohanty, Montano, Moore, Myllynen, Neuber, Niewiesk, Ober, Ober, Oganesyan, Okoko, Okoko, Okoko, Okoko, Omata, Osendarp, Palmeira, Palmer, Poehling, Porter, Poulsen, Powner, Qiao, Raghavan, Raghavan, Reynolds, Roux, Sand, Saso, Schlaudecker, Schofield, Scott, Sgarbosa, Silveira Lessa, Simister, Simister, Simister, Stach, Stapleton, Stapleton, Syme, Tabata, Takizawa, Tapia, Thomann, Tzaban, van den Berg, van den Berg, Viall, Vidarsson, Vidarsson, Vogelzang, Vähäkangas, West, Williams, Winter, Wormald, Wypych, Zaman, Zhu   +147 more
core   +2 more sources