Results 31 to 40 of about 121,959 (273)
US Neurology, 2022 Myasthenia gravis (MG) is a rare autoimmune disorder characterized by fatigue and muscle weakness. About 85–90% of patients with generalized MG display pathogenic immunoglobulin (Ig)G antibodies against the skeletal muscle nicotinic acetylcholine ...
F. Vanoli, R. Mantegazza
semanticscholar +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2022 The amplification of weak transient protein–protein interactions to elicit robust immune responses is a recurring theme in immune processes (1) (Fig. 1).
Paul R. Sargunas, Jamie B. Spangler
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Generating Recombinant Antibodies against Putative Biomarkers of Retinal Injury. [PDF]
PLoS ONE, 2015 Candidate biomarkers, indicative of disease or injury, are beginning to overwhelm the process of validation through immunological means. Recombinant antibodies developed through phage-display offer an alternative means of generating monoclonal antibodies
Michael R Kierny +4 more
doaj +1 more source
, 2010 Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
Graebsch, Almut +4 more
core +1 more source
Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy
Engineering, 2023 Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear.
Huifang Wu +13 more
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Tumor necrosis factor inhibitors in psoriatic arthritis. [PDF]
, 2017 INTRODUCTION: Psoriatic arthritis (PsA) is a chronic inflammatory disease that can result in significant disability. With the emergence of tumor necrosis factor inhibitors (TNFi), therapeutic outcomes in PsA have improved substantially.
Kraft, Walter K. +2 more
core +2 more sources
Next generation Fc scaffold for multispecific antibodies
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
doaj +1 more source
Efgartigimod, an FcRn antagonist, as a potential treatment for post COVID-19 syndrome
Acta Materia Medica, 2023 A significant proportion of patients who survive coronavirus disease of 2019 (COVID-19) develop a constellation of life-altering symptoms that persist long after the initial infection has resolved.
Sandra E. Reznik +2 more
doaj +1 more source
Immunoglobulin G fragment crystallizable glycosylation after hematopoietic stem cell transplantation is dissimilar to donor profiles [PDF]
, 2018 Immunoglobulin G (IgG) fragment crystallizable (Fc) N-glycosylation has a large influence on the affinity of the antibody for binding to Fcγ-receptors (FcγRs) and C1q protein, thereby influencing immune effector functions.
de Haan, N. (Noortje) +4 more
core +3 more sources
Frontiers in Immunology, 2020 N-linked glycans play an important role in immunity. Although the role of N-linked glycans in the Fragment crystallizable (Fc) region of immunoglobulins has been thoroughly described, the function of N-linked glycans present in Ig-variable domains is ...
E. Vletter +4 more
semanticscholar +1 more source