Results 31 to 40 of about 8,200 (248)

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production [PDF]

, 2017
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies
Battella, Simone, Belardinilli, Francesca, Capuano, Cristina, Galandrini, Ricciarda, Giannini, Giuseppe, Molfetta, Rosa, Palmieri, Gabriella, Paolini, Rossella, Pighi, Chiara, Santoni, Angela   +9 more
core   +2 more sources

Advances in therapeutic Fc engineering - modulation of IgG associated effector functions and serum half-life

Frontiers in Immunology, 2016
Today monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
Abhishek Saxena, Donghui Wu
doaj   +1 more source

Camelid VHHs Fused to Human Fc Fragments Provide Long Term Protection Against Botulinum Neurotoxin A in Mice

Toxins, 2019
The bacterium Clostridium botulinum is the causative agent of botulism—a severe intoxication caused by botulinum neurotoxin (BoNT) and characterized by damage to the nervous system. In an effort to develop novel C.
Svetlana A. Godakova, Anatoly N. Noskov, Irina D. Vinogradova, Galina A. Ugriumova, Andrey I. Solovyev, Ilias B. Esmagambetov, Amir I. Tukhvatulin, Denis Y. Logunov, Boris S. Naroditsky, Dmitry V. Shcheblyakov, Aleksandr L. Gintsburg   +10 more
doaj   +1 more source

B Cell-Based Seamless Engineering of Antibody Fc Domains. [PDF]

PLoS ONE, 2016
Engineering of monoclonal antibodies (mAbs) enables us to obtain mAbs with additional functions. In particular, modifications in antibody's Fc (fragment, crystallizable) region can provide multiple benefits such as added toxicity by drug conjugation ...
Koji Hashimoto, Kohei Kurosawa, Akiho Murayama, Hidetaka Seo, Kunihiro Ohta   +4 more
doaj   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source

Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Frontiers in Plant Science, 2022
The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh, Advaita Acarya Singh, Priyen Pillay, Previn Naicker, Kabamba Alexandre, Kanyane Malatji, Lukas Mach, Herta Steinkellner, Juan Vorster, Rachel Chikwamba, Tsepo L. Tsekoa   +10 more
doaj   +1 more source

Spinodal-assisted crystallization in polymer melts [PDF]

, 1998
Recent experiments in some polymer melts quenched below the melting temperature have reported spinodal kinetics in small-angle x-ray scattering before the emergence of a crystalline structure.
A. J. Ryan, G. Goldbeck-Wood, G. Strobl, I. I. Frenkel, J. Brandrup, J. D. Gunton, J. D. McCoy, J. W. Cahn, J. W. Martin, K. Kawasaki, L. D. Landau, L. R. Pratt, M. Cakmak, M. Dettenmaier, M. Imai, M. Imai, M. R. L. Evans, N. J. Terrill, N. J. Terrill, P. D. Olmsted, P. J. Flory, P. R. ten Wolde, S. Alexander, S. Harrington, T. A. Ezquerra, T. C. B. McLeish, T. Dehoff, T. Kanaya, W. C. K. Poon, W. C. K. Poon, W. C. K. Poon   +30 more
core   +2 more sources

FFAS server: novel features and applications. [PDF]

, 2011
The Fold and Function Assignment System (FFAS) server [Jaroszewski et al. (2005) FFAS03: a server for profile-profile sequence alignments. Nucleic Acids Research, 33, W284-W288] implements the algorithm for protein profile-profile alignment introduced ...
Cai, Xiao-hui, Godzik, Adam, Jaroszewski, Lukasz, Li, Zhanwen, Weber, Christoph   +4 more
core   +3 more sources

Neospora caninum as delivery vehicle for anti-PD-L1 scFv-Fc: A novel approach for cancer immunotherapy

Molecular Therapy: Oncology
Neospora caninum, a potential anticancer agent able to reactivate the immune response within the tumor microenvironment (TME), has recently shown enhanced immunomodulatory properties in different tumor models when armed with the cytokine, Il-15.
Clément Riviere, Muna Aljieli, Marie-Noëlle Mévélec, Louis Lantier, Fanny Boursin, Laurie Lajoie, Céline Ducournau, Stéphanie Germon, Nathalie Moiré, Isabelle Dimier-Poisson, Nicolas Aubrey, Anne di Tommaso   +11 more
doaj   +1 more source

Current Advances in γδ T Cell-Based Tumor Immunotherapy [PDF]

, 2017
γδ T cells are a minor population (~5%) of CD3 T cells in the peripheral blood, but abound in other anatomic sites such as the intestine or the skin.
Cocorullo, Gianfranco, Dieli, Francesco, Gulotta, Eliana, Gulotta, Gaspare, LO PRESTI, Elena, Meraviglia, Serena, Pizzolato, Gabriele   +6 more
core   +1 more source