Results 41 to 50 of about 121,959 (273)

Common light chain chickens produce human antibodies of high affinity and broad epitope coverage for the engineering of bispecifics

mAbs, 2021
Bispecific antibodies are an important and growing segment in antibody therapeutics, particularly in the immuno-oncology space. Manufacturing of a bispecific antibody with two different heavy chains is greatly simplified if the light chains can be the ...
Kathryn H. Ching, Kimberley Berg, Kevin Reynolds, Darlene Pedersen, Alba Macias, Yasmina N. Abdiche, William D. Harriman, Philip A. Leighton   +7 more
doaj   +1 more source

High-level fed-batch fermentative expression of an engineered Staphylococcal protein A based ligand in E. coli: purification and characterization [PDF]

, 2015
The major platform for high level recombinant protein production is based on genetically modified microorganisms like Escherichia coli (E. coli) due to its short dividing time, ability to use inexpensive substrates and additionally, its genetics is ...
Fernández Lahore, Marcelo, Gorrepati, Kanaka Durga Devi, Grasselli, Mariano, Kangwa, Martin, Polat, Ayse Nur, Yelemane, Vikas   +5 more
core   +1 more source

Obinutuzumab-mediated high-affinity ligation of FcγRIIIA/CD16 primes NK cells for IFNγ production [PDF]

, 2017
Natural killer (NK) cell-mediated antibody-dependent cellular cytotoxicity (ADCC), based on the recognition of IgG-opsonized targets by the low-affinity receptor for IgG FcγRIIIA/CD16, represents one of the main mechanisms by which therapeutic antibodies
Battella, Simone, Belardinilli, Francesca, Capuano, Cristina, Galandrini, Ricciarda, Giannini, Giuseppe, Molfetta, Rosa, Palmieri, Gabriella, Paolini, Rossella, Pighi, Chiara, Santoni, Angela   +9 more
core   +2 more sources

Molecular Dynamics Simulation of the Crystallizable Fragment of IgG1—Insights for the Design of Fcabs

International Journal of Molecular Sciences, 2014
An interesting format in the development of therapeutic monoclonal antibodies uses the crystallizable fragment of IgG1 as starting scaffold. Engineering of its structural loops allows generation of an antigen binding site.
Balder Lai, Christoph Hasenhindl, C. Obinger, C. Oostenbrink   +3 more
semanticscholar   +1 more source

Fc-Linked IgG N-Glycosylation in FcγR Knock-Out Mice

Frontiers in Cell and Developmental Biology, 2020
Immunoglobulin G (IgG) is the most abundant immunoglobulin isotype in the blood and is involved in the pathogenesis and progression of various diseases.
Olga O. Zaytseva, Michaela Seeling, Jasminka Krištić, Gordan Lauc, Gordan Lauc, Marija Pezer, Falk Nimmerjahn   +6 more
doaj   +1 more source

Factors Affecting the FcRn-Mediated Transplacental Transfer of Antibodies and Implications for Vaccination in Pregnancy. [PDF]

, 2017
At birth, neonates are particularly vulnerable to infection and transplacental transfer of immunoglobulin G (IgG) from mother to fetus provides crucial protection in the first weeks of life.
Abdiche, Abourawi, Abu-Raya, Amirthalingam, Amirthalingam, Antohe, Atwell, Bainbridge, Bakchoul, Baker, Baker, Basha, Bialas, Bondt, Brair, Brambell, Brambell, Brambell, Bruhns, Calderon, Calvert, Cavalcante, Chen, Chu, Cumberland, Dabrera, Dashivets, de Moraes-Pinto, de Souza, Dillon, Einarsdottir, Einarsdottir, Ellinger, Ellinger, Englund, Faucette, Faucette, Firan, Fowden, França, Fu, Gaither, Gall, Goldfarb, Griffiths, Hamilton, Hammes, Hanson, Hartter, Hashira, Heath, Heidl, Henkle, Heron, Holder, Holland, Hornby, Huhn, Jansen, Jauniaux, Jefferis, Jones, Junghans, Kennedy, Kibe, Kim, Kim, Kim, Kohler, Kristoffersen, Ladhani, Leach, Leitner, Li, Li, Lightle, Madhi, Maertens, Malek, Malek, Mammaro, Martin, Martins, Mathiesen, Mathiesen, Medesan, Mestas, Mimura, Mitchell, Mohanty, Montano, Moore, Myllynen, Neuber, Niewiesk, Ober, Ober, Oganesyan, Okoko, Okoko, Okoko, Okoko, Omata, Osendarp, Palmeira, Palmer, Poehling, Porter, Poulsen, Powner, Qiao, Raghavan, Raghavan, Reynolds, Roux, Sand, Saso, Schlaudecker, Schofield, Scott, Sgarbosa, Silveira Lessa, Simister, Simister, Simister, Stach, Stapleton, Stapleton, Syme, Tabata, Takizawa, Tapia, Thomann, Tzaban, van den Berg, van den Berg, Viall, Vidarsson, Vidarsson, Vogelzang, Vähäkangas, West, Williams, Winter, Wormald, Wypych, Zaman, Zhu   +147 more
core   +2 more sources

Advances in therapeutic Fc engineering - modulation of IgG associated effector functions and serum half-life

Frontiers in Immunology, 2016
Today monoclonal immunoglobulin gamma (IgG) antibodies have become a major option in cancer therapy especially for the patients with advanced or metastatic cancers.
Abhishek Saxena, Donghui Wu
doaj   +1 more source

Transient proteolysis reduction of Nicotiana benthamiana-produced CAP256 broadly neutralizing antibodies using CRISPR/Cas9

Frontiers in Plant Science, 2022
The hypersensitive response is elicited by Agrobacterium infiltration of Nicotiana benthamiana, including the induction and accumulation of pathogenesis-related proteins, such as proteases.
Advaita Acarya Singh, Advaita Acarya Singh, Priyen Pillay, Previn Naicker, Kabamba Alexandre, Kanyane Malatji, Lukas Mach, Herta Steinkellner, Juan Vorster, Rachel Chikwamba, Tsepo L. Tsekoa   +10 more
doaj   +1 more source

B Cell-Based Seamless Engineering of Antibody Fc Domains. [PDF]

PLoS ONE, 2016
Engineering of monoclonal antibodies (mAbs) enables us to obtain mAbs with additional functions. In particular, modifications in antibody's Fc (fragment, crystallizable) region can provide multiple benefits such as added toxicity by drug conjugation ...
Koji Hashimoto, Kohei Kurosawa, Akiho Murayama, Hidetaka Seo, Kunihiro Ohta   +4 more
doaj   +1 more source

Forced Degradation Testing as Complementary Tool for Biosimilarity Assessment [PDF]

, 2019
Oxidation of monoclonal antibodies (mAbs) can impact their efficacy and may therefore represent critical quality attributes (CQA) that require evaluation.
Dyck, Yan Felix Karl, Jabs, Wolfgang, Joseph, Jan Felix, Parr, Maria Kristina, Rehm, Daniel, Sandig, Volker, Winkler, Karsten   +6 more
core   +1 more source