Results 51 to 60 of about 8,200 (248)

Structure of a highly conserved domain of rock1 required for shroom-mediated regulation of cell morphology [PDF]

, 2013
Rho-associated coiled coil containing protein kinase (Rho-kinase or Rock) is a well-defined determinant of actin organization and dynamics in most animal cells characterized to date.
A Rolo, AC Martin, AL Mikheikin, Alan S. Fanning, AM Edelman, AN Tullio, Andrew P. VanDemark, Annie Heroux, AS Grosse, AT McGeoch, Atinuke M. Dosunmu-Ogunbi, C Bolinger, C Lee, CP Heisenberg, D Tu, Debamitra Das, FW Studier, GM Sheldrick, H Yamaguchi, IW Davis, J Feng, JD Hildebrand, JD Hildebrand, Jeffrey D. Hildebrand, Jenna K. Zalewski, JM Sawyer, K Fujisawa, KH Seong, L Goldschmidt, M Amano, M Amano, M Ikebe, M Ikebe, M Jacobs, M Sebbagh, M Strong, M Tariq, MA Conti, MI Chung, Michael A. Trakselis, MJ Farber, ML Coleman, ML Dietz, N Yamamoto, O Hagens, P Emsley, PD Adams, PD Fairbank, PT Tuazon, R Dvorsky, R Maesaki, Robert J. Bauer, RS Fischer, S Araki, S Ernst, S Mohan, S Tumusiime, Simone Heber, SL Haigo, Swarna Mohan, T Ishizaki, T Leung, T Nishimura, T Shimizu, TF Plageman, TF Plageman, TF Plageman, W Mehio, Z Chen, ZOaW Minor   +69 more
core   +9 more sources

Differences in human IgG1 and IgG4 S228P monoclonal antibodies viscosity and self-interactions: Experimental assessment and computational predictions of domain interactions

mAbs, 2021
Human/humanized IgG4 antibodies have reduced effector function relative to IgG1 antibodies, which is desirable for certain therapeutic purposes. However, the developability and biophysical properties for IgG4 antibodies are not well understood. This work
Pin-Kuang Lai, Gaurav Ghag, Yao Yu, Veronica Juan, Laurence Fayadat-Dilman, Bernhardt L. Trout   +5 more
doaj   +1 more source

Immunity against fungal beta 1,3 glucan carbohydrate in the gastrointestinal tract [PDF]

, 2016
Inflammatory Bowel Disease (IBD) is a debilitating, life- long disease that affects about 1.4 millions Americans. Little is known about the pathogenesis of IBD and an effective cure still remains to be discovered.
Feliu, Marianela
core   +1 more source

Unique Performance Considerations for Printable Organic Semiconductor and Perovskite Radiation Detectors: Toward Consensus on Best Practice Evaluation

Advanced Functional Materials, EarlyView.
A lack of standard approaches for testing and reporting the performance of metal halide perovskites and organic semiconductor radiation detectors has resulted in inconsistent interpretation of performance parameters, impeding progress in the field. This Perspective recommends key metrics and experimental details, which are suggested for reporting in ...
Jessie A. Posar, Matthew Large, Andrea Ciavatti, Laura Basiricò, Beatrice Fraboni, Paul J. Sellin, Attila J. Mozer, Marco Petasecca, Matthew J. Griffith   +8 more
wiley   +1 more source

A plant-biotechnology approach for producing highly potent anti-HIV antibodies for antiretroviral therapy consideration

Journal of Genetic Engineering and Biotechnology, 2021
Despite a reduction in global HIV prevalence the development of a pipeline of new therapeutics or pre-exposure prophylaxis to control the HIV/AIDS epidemic are of high priority.
Advaita Acarya Singh, Priyen Pillay, Lusisizwe Kwezi, Tsepo Lebiletsa Tsekoa   +3 more
doaj   +1 more source

Enhancing Direct Solar Water Splitting via ALD of Multifunctional TiO2/Pt Nanoparticle Coatings With Engineered Interfaces to GaAs/GaInP Tandem Cells

Advanced Functional Materials, EarlyView.
Multifunctional atomic layer deposited coatings and interface treatments enhance direct solar water splitting on GaAs/GaInP tandem cells. Optimized TiO2/Pt nanoparticle bilayers ensure durability and catalytic efficiency with minimal optical losses, while H2 plasma pretreatments maximize photovoltage and interfacial charge extraction.
Tim F. Rieth, Verena Streibel, Oliver Bienek, Sergej Levashov, Johannes Dittloff, Kristof Möller, Johanna Eichhorn, Matthias M. May, Ian D. Sharp   +8 more
wiley   +1 more source

Modulating Two‐Photon Absorption in a Pyrene‐Based MOF Series: An In‐Depth Investigation of Structure–Property Relationships

Advanced Functional Materials, EarlyView.
This study investigates H4TBAPy‐based metal–organic frameworks (MOFs) ‐ NU‐1000, NU‐901, SrTBAPy, and BaTBAPy ‐ for multiphoton absorption (MPA) performance. It observes topology‐dependent variations in the 2PA cross‐section, with BaTBAPy exhibiting the highest activity.
Simon N. Deger, Helmy Pacheco Hernandez, Yang Cui, Hongxing Hao, Vanessa Ramm, David C. Mayer, Khai‐Nghi Truong, Roland A. Fischer, Jürgen Hauer, Mariana Kozlowska, Alexander Pöthig   +10 more
wiley   +1 more source

Natural Killer Cells in Antibody Independent and Antibody Dependent HIV Control

Frontiers in Immunology, 2022
Infection with the human immunodeficiency virus (HIV), when left untreated, typically leads to disease progression towards acquired immunodeficiency syndrome.
Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Nicole F. Bernard, Sanket Kant, Sanket Kant, Sanket Kant, Zahra Kiani, Zahra Kiani, Zahra Kiani, Cécile Tremblay, Cécile Tremblay, Franck P. Dupuy, Franck P. Dupuy   +13 more
doaj   +1 more source

Global and Local Conformation of Human IgG Antibody Variants Rationalizes Loss of Thermodynamic Stability. [PDF]

, 2015
Immunoglobulin G (IgG) monoclonal antibodies (mAbs) are a major class of medicines, with high specificity and affinity towards targets spanning many disease areas. The antibody Fc (fragment crystallizable) region is a vital component of existing antibody
Edgeworth, Matthew J, Higazi, Daniel R, Kippen, Alistair D, Lowe, David C, Phillips, Jonathan J, Scrivens, James H   +5 more
core   +1 more source

Near‐Infrared Emitting Lanthanide Catecholate Giant Single Crystals – Morphology Control and Photon Down‐Conversion

Advanced Functional Materials, EarlyView.
Controlled syntheses of lanthanide coordination polymers based on the dihydroxybenzoquinone (DHBQ) organic linker afforded large single crystals of Ln‐DHBQ CPs (Ln = Yb, Nd). A novel structural variant of Yb‐DHBQ is identified by means of single crystal diffraction analysis.
Marina I. Schönherr, Alexander Biewald, Andre Mähringer, Thaddäus J. Koller, Peter Mayer, Markus Döblinger, Achim Hartschuh, Dana D. Medina   +7 more
wiley   +1 more source