Results 51 to 60 of about 7,556 (242)
Half-Life Extension Enhances Drug Efficacy in Adeno-Associated Virus Delivered Gene Therapy
Engineering, 2023 Prolonged half-life of protein-based therapeutics can improve drug efficacy. However, the impact of drug half-life on gene therapy, which inherently provides long-lasting production of the desired therapeutic protein, remains unclear.
Huifang Wu +13 more
doaj
Advanced Biology, EarlyView.In this study, a new type of bioactive glass fiber ‐based composite magnesium phosphate bone cement is prepared and verified that its mechanical strength and biological properties. In addition, the cement may have played a biologically active role in the Notch and HIF signaling pathways.
Yuzheng Lu +12 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.This study explores the energy conversion in powder bed fusion of polymers using laser beam for polyamide 12 and polypropylene powders. It combines material and process data, using dimensionless parameters and numerical models, to enable the prediction of suitable printing parameters.
Christian Schlör +9 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.This study presents rapid evaluation methods for scan strategies in powder bed fusion (PBF) of polymers with a NIR laser as an example for its application. It uses line buffer‐based calculations and point density fields to predict the performance of four different scan strategies. The methods show promising results in laser‐based PBF of polymer samples,
Simon Leupold +9 more
wiley +1 more source
Molecular modeling of antibodies for the treatment of TNFα-related immunological diseases [PDF]
, 2016 Therapeutic monoclonal antibodies (mAbs) have high efficacy in treating TNF α-related immunological diseases. Other than neutralizing TNF α, these IgG1 antibodies exert Fc receptor-mediated effector functions such as the complement-dependent cytotoxicity
BOSSIS, FABRIZIO +6 more
core +1 more source
Performance Comparison of Surface Sensitizers for Diode Laser Powder Bed Fusion of Polyamide 12
Advanced Engineering Materials, EarlyView.Laser‐generated nanoparticles transform standard PA12 powders into high‐performance, dye‐free feedstocks for diode laser 3D printing. Despite identical absorbance at 808 nm, CuS, LaB6, and CB coatings reveal striking differences in fusion and strength—unlocking new design space for recyclable, industrial‐grade polymers.
Michael Willeke +9 more
wiley +1 more source
Next generation Fc scaffold for multispecific antibodies
iScience, 2021 Summary: Bispecific antibodies (Bispecifics) demonstrate exceptional clinical potential to address some of the most complex diseases. However, Bispecific production in a single cell often requires the correct pairing of multiple polypeptide chains for ...
Bram Estes +11 more
doaj
Enhanced immunogenic potential of cancer immunotherapy antibodies in human IgG1 transgenic mice
mAbs, 2022 Clinical anti-drug-antibody (ADA) responses represent a substantial obstacle to the development of efficacious therapeutic antibodies. The enhanced ADA production against the idiotype (Id) often displayed by cancer immunotherapy antibodies (CitAbs) can ...
Jerome Egli +17 more
doaj +1 more source
Advanced Functional Materials, EarlyView.PBTTT‐OR‐R, a C14‐alkoxy/alkyl‐PBTTT polymer derivative, is of substantial interest for optoelectronics due to its specific fullerene intercalation behavior and enhanced charge‐transfer absorption. Comparing this polymer with (S) and without (O) homocoupling defects reveals that PBTTT‐OR‐R(O) forms stable co‐crystals with PC61BM, while PBTTT‐OR‐R(S ...
Zhen Liu +14 more
wiley +1 more source
The Neonatal Fc Receptor (FcRn): A Misnomer?
Frontiers in Immunology, 2019 Antibodies are essential components of an adaptive immune response. Immunoglobulin G (IgG) is the most common type of antibody found in circulation and extracellular fluids.
Michal Pyzik +9 more
doaj +1 more source