Results 81 to 90 of about 7,556 (242)

Immunoglobulin-Related Fibroinflammatory Diseases of Uncertain Etiology—Polarized Isotype Switching Connects an Ancient with a Contemporary Disease

Lymphatics
IgG4 is an unusual immunoglobulin (Ig) and is the least component of IgG in humans. It is often asymmetrical and heterobivalent with weak Fc (fragment crystallizable region)-dependent effector function and ineffective complement activation, thus playing ...
Chi Sing Ng
doaj   +1 more source

Expression, Purification, and Biophysical Characterization of a Secreted Anthrax Decoy Fusion Protein in Nicotiana benthamiana. [PDF]

, 2017
Anthrax toxin receptor-mediated drug development for blocking anthrax toxin action has received much attention in recent decades. In this study, we produced a secreted anthrax decoy fusion protein comprised of a portion of the human capillary ...
Dandekar, Abhaya M, Duhra-Gill, Sifti, Kailemia, Muchena J, Karuppanan, Kalimuthu, Lebrilla, Carlito B, McDonald, Karen A, Nandi, Somen, Phu, My L, Rodriguez, Raymond L   +8 more
core   +2 more sources

Computational Modeling of Reticular Materials: The Past, the Present, and the Future

Advanced Materials, EarlyView.
Reticular materials are advanced materials with applications in emerging technologies. A thorough understanding of material properties at operating conditions is critical to accelerate the deployment at an industrial scale. Herein, the status of computational modeling of reticular materials is reviewed, supplemented with topical examples highlighting ...
Wim Temmerman, Ruben Goeminne, Kuber Singh Rawat, Veronique Van Speybroeck   +3 more
wiley   +1 more source

Generation of Chimeric Antibody Light Chain Plasmid [PDF]

, 2014
In order to determine the distance between the antigen-binding site and the fragment crystallizable (Fc) region of an antibody using single-molecule Förster Resonance Energy Transfer, dyes must be attached to these locations.
Arendt, Lily
core   +1 more source

Advancements in Understanding the Physicochemical Properties of Reticular Materials: An In Situ and Operando Spectroscopic Perspective

Advanced Materials, EarlyView.
This review explores how in situ and operando spectroscopic techniques reveal the real‐time behavior of reticular materials, including MOFs and COFs. These methods track material formation and functionalization, structural changes, defect formation, dynamic responses to external triggers, and catalytic processes.
Bettina Baumgartner, Anna Wach, Xinwei Ye, Evelyn Ploetz, Bert M. Weckhuysen   +4 more
wiley   +1 more source

Of Bits and Bugs — On the Use of Bioinformatics and a Bacterial Crystal Structure to Solve a Eukaryotic Repeat-Protein Structure [PDF]

, 2010
Pur-α is a nucleic acid-binding protein involved in cell cycle control, transcription, and neuronal function. Initially no prediction of the three-dimensional structure of Pur-α was possible.
A Biegert, A Biegert, A Graebsch, A Hildebrand, A Marchler-Bauer, A Sali, A Savchenko, AA Vaguine, AD Bergemann, AJ McCoy, AK Bjorklund, Almut Graebsch, AM Waterhouse, B Rost, BM Lunde, C Chothia, CJ Oldfield, D Fischer, Dierk Niessing, Dirk Kostrewa, DT Jones, EM Marcotte, F Melo, GL Gallia, GL Hura, GM Sheldrick, GN Murshudov, I Wong, J Söding, J Söding, JN Battey, Johannes Söding, K Khalili, M Müller, MA Larkin, MK White, NE Chayen, Niall James Haslam, P Emsley, P Koehl, R Luthy, R Page, RD Finn, RI Sadreyev, RP Bahadur, S Doublie, S Hunter, SF Altschul, SN Ho, Stéphane Roche, TC Terwilliger, W Kabsch, WN Price 2nd, X Gao, Y Kanai   +54 more
core   +3 more sources

State‐of‐the‐Art, Insights, and Perspectives for MOFs‐Nanocomposites and MOF‐Derived (Nano)Materials

Advanced Materials, EarlyView.
Different approaches to MOF‐NP composite formation, such as ship‐in‐a‐bottle, bottle‐around‐the‐ship and in situ one‐step synthesis, are used. Owing to synergistic effects, the advantageous features of the components of the composites are beneficially combined, and their individual drawbacks are mitigated.
Stefanos Mourdikoudis, Subhajit Dutta, Saqib Kamal, Sergio Gómez‐Graña, Isabel Pastoriza‐Santos, Stefan Wuttke, Lakshminarayana Polavarapu   +6 more
wiley   +1 more source

MS-Based Allotype-Specific Analysis of Polyclonal IgG-Fc N-Glycosylation

Frontiers in Immunology, 2020
Current approaches to study glycosylation of polyclonal human immunoglobulins G (IgG) usually imply protein digestion or glycan release. While these approaches allow in-depth characterization, they also result in a loss of valuable information regarding ...
Thomas Sénard, Andrea F. G. Gargano, Andrea F. G. Gargano, David Falck, Steven W. de Taeye, Steven W. de Taeye, Theo Rispens, Gestur Vidarsson, Manfred Wuhrer, Govert W. Somsen, Elena Domínguez-Vega   +10 more
doaj   +1 more source

On‐the‐Fly Synthesis of Freestanding Spin‐Crossover Architectures With Tunable Magnetic Properties

Advanced Materials, EarlyView.
3D flow‐focusing devices are an ideal platform for the processing and integration of functional materials within polymeric matrices. In this article, A. Tuan Ngo, D. Aguilà, T. Sotto Mayor, M. Palacios‐Corella, J. Puigmartí‐Luis show the on‐the‐fly processing of a prototypical SCO material—known for its challenging processability—thereby opening new ...
Anh Tuan Ngo, David Aguilà, João Pedro Vale, Semih Sevim, Michele Mattera, Jordi Díaz‐Marcos, Ramon Pons, Guillem Aromí, Bumjin Jang, Salvador Pané, Tiago Sotto Mayor, Mario Palacios‐Corella, Josep Puigmartí‐Luis   +12 more
wiley   +1 more source

PCSK9 stimulates Syk, PKCδ, and NF-κB, leading to atherosclerosis progression independently of LDL receptor

Nature Communications
Proprotein convertase subtilisin/kexin type-9 (PCSK9) binds to and degrades low-density lipoprotein (LDL) receptor, leading to increase of LDL cholesterol in blood. Its blockers have emerged as promising therapeutics for cardiovascular diseases.
Dasom Shin, Soungchan Kim, Hwan Lee, Hyun-Chae Lee, Jaewon Lee, Hyun-woo Park, Mina Fukai, EunByule Choi, Subin Choi, Bon-Jun Koo, Ji-Hoon Yu, Gyurae No, Sungyoon Cho, Chan Woo Kim, Dohyun Han, Hyun-Duk Jang, Hyo-Soo Kim   +16 more
doaj   +1 more source