Results 71 to 80 of about 396,346 (245)

Land Cover Change in the Andes of Southern Ecuador—Patterns and Drivers

Remote Sensing, 2015
In the megadiverse tropical mountain forest in the Andes of southern Ecuador, a global biodiversity hotspot, the use of fire to clear land for cattle ranching is leading to the invasion of an aggressive weed, the bracken fern, which is threatening ...
Giulia F. Curatola Fernández, Wolfgang A. Obermeier, Andrés Gerique, María Fernanda López Sandoval, Lukas W. Lehnert, Boris Thies, Jörg Bendix   +6 more
doaj   +1 more source

Monitoring of circulating tumor DNA allows early detection of disease relapse in patients with operable breast cancer

Molecular Oncology, EarlyView.
Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad, Marie Austdal, Oddmund Nordgård, Gunnar Mellgren, Satu Oltedal, Marie L. Austbø, Ylva H. Vignes, Thomas Helland, Kristin Jonsdottir, Tone H. Lende, Emilius A. M. Janssen, Bjørnar Gilje, Kjersti Tjensvoll, PBCB study group, Gunnar Mellgren, Tone Hoel Lende, Anette Heie, Kristin Viste, Anita Røyneberg Alvheim, Emiel AM Janssen, Kristin Jonsdottir, Ann Cathrine Kroksveen, Thomas Helland, Einar Gudlaugsson, Oddmund Nordgård, Satu Oltedal, Kristin Løge Aanestad, Jan Terje Kvaløy, Kirsten Lode, Kari Britt Hagen, Marie Austdal, Ylva H. Vignes, Siri Tungland Sola, Nina Egeland Amundsen, Finn Magnus Eliassen, Emeritus Ernst A Lien   +35 more
wiley   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Elevated Levels of Herbivory in Urban Landscapes: Are Declines in Tree Health More Than an Edge Effect?

Ecology and Society, 2005
Urbanization is one of the most extreme and rapidly growing anthropogenic pressures on the natural world. Urban development has led to substantial fragmentation of areas of natural habitat, resulting in significant impacts on biodiversity and disruptions
Fiona J. Christie, Dieter F. Hochuli
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Chronic Insomnia Is Associated with Higher Circulating Interleukin-8 in Patients with Atherosclerotic Cerebral Small Vessel Disease

Nature and Science of Sleep, 2020
Jihui Wang,1 Xiaodong Chen,2 Xuejiao Men,2 Minhua Chen,1 Jiong Tao,1 Zhengqi Lu2 1Department of Psychiatry, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, People’s Republic of China; 2Department of Neurology, the Third ...
Wang J, Chen X, Men X, Chen M, Tao J, Lu Z   +5 more
doaj  

A Systematic Comparison of Cultural and Ecological Landscape Corridors in Europe

Land, 2019
Landscape corridors are narrow strips of land that differ from the matrix on either side. In addition to providing connectivity between fragmented landscapes, these corridors serve scenic, cultural, social, ecological, and recreational purposes.
Haiyun Xu, Tobias Plieninger, Jørgen Primdahl   +2 more
doaj   +1 more source

Fragments, fragmentations

Calenda, 2019
Le topique du fragment est transversal à l’ensemble des sciences humaines et sociales. Il s’y décline diversement comme autant de modalités d’une incomplétude et souvent, par extension, d’une déficience. Les séances de ce séminaire viseront à identifier les potentialités du fragment en tant que tel pour l’investigation scientifique.
openaire   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

New-record of the bush dog speothos venaticus in a human-altered landscape in west Minas Gerais, Brazil

Bioscience Journal, 2016
The bush dog (Speothos venaticus) is a Neotropical canid with a wide geographic distribution. Although globally listed as Near Threatened, this species was listed as Vulnerable in a recent assessment by the Brazilian government.
Fernanda Cavalcanti Azevedo, Frederico Gemesio Lemos, Alan Nilo Costa, Daniel Gomes Rocha, Mozart Caetano de Freitas-Junior   +4 more
doaj   +1 more source