Results 11 to 20 of about 291 (138)

Liquid biopsy for early detection of hepatocellular carcinoma [PDF]

Frontiers in Medicine, 2023
Hepatocellular carcinoma (HCC) is a highly prevalent and lethal cancer globally. Over 90% of HCC cases arise in the context of liver cirrhosis, and the severity of the underlying liver disease or advanced tumor stage at diagnosis significantly limits ...
Ioana Manea, Ioana Manea, Ioana Manea, Razvan Iacob, Razvan Iacob, Razvan Iacob, Speranta Iacob, Speranta Iacob, Speranta Iacob, Razvan Cerban, Razvan Cerban, Razvan Cerban, Simona Dima, Simona Dima, Simona Dima, Gabriel Oniscu, Irinel Popescu, Irinel Popescu, Liliana Gheorghe, Liliana Gheorghe, Liliana Gheorghe   +20 more
doaj   +2 more sources

Identification of ᴅ-amino acid-containing peptides in human serum. [PDF]

PLoS ONE, 2017
Biologically uncommon d-aspartate (d-Asp) residues have been shown to accumulate in proteins associated with age-related human disorders, such as cataract and Alzheimer disease.
Seongmin Ha, Ingu Kim, Takumi Takata, Tadatoshi Kinouchi, Masaharu Isoyama, Minoru Suzuki, Noriko Fujii   +6 more
doaj   +2 more sources

Detection of known gene fusions in cancer cell lines using whole-genome bisulfite sequencing data [PDF]

Scientific Reports
Whole-genome bisulfite sequencing (WGBS) provides multiple molecular information layers including methylation, copy number variations (CNVs), single nucleotide variants (SNVs), and fragmentome patterns in cell-free DNA (cfDNA) while gene fusion detection
Taehoon Kim, Duhee Bang
doaj   +2 more sources

Prognostic significance of circulating tumor DNA in non-metastatic colorectal cancer [PDF]

Discover Oncology
Purpose Circulating tumor DNA (ctDNA) is the small fragments of DNA released by tumor cells into the blood. By detecting the abnormal changes in ctDNA in the blood, it can assist in the early screening of cancer, monitoring of treatment efficacy, early ...
Ruiyang Li, Shuchao Wang, Jie Xu, Min Zhao, Heng Zhang, Yibo Yin, Xue Han, Baojun Liu, Wenjian Liu   +8 more
doaj   +2 more sources

Methodology for Biological Sample Collection, Processing, and Storage in the Newcastle 1000 Pregnancy Cohort: Protocol for a Longitudinal, Prospective Population-Based Study in Australia [PDF]

JMIR Research Protocols
BackgroundResearch in the developmental origins of health and disease provides compelling evidence that adverse events during the first 1000 days of life from conception can impact life course health.
Joshua J Fisher, Tegan Grace, Nathan A Castles, Elizabeth A Jones, Sarah J Delforce, Alexandra E Peters, Gabrielle K Crombie, Emily C Hoedt, Kirby E Warren, Richard GS Kahl, Jonathan J Hirst, Kirsty G Pringle, Craig E Pennell   +12 more
doaj   +2 more sources

Quantitative fragmentomics allow affinity mapping of interactomes [PDF]

Nature Communications, 2021
Abstract Human protein networks have been widely explored but most binding affinities remain unknown, hindering quantitative interactome-function studies. Yet interactomes rely on minimal interacting fragments displaying quantifiable affinities.
Gogl, Gergo, Zambo, Boglarka, Kostmann, Camille, Cousido-Siah, Alexandra, Morlet, Bastien, Durbesson, Fabien, Negroni, Luc, Eberling, Pascal, Jané, Pau, Nominé, Yves, Zeke, Andras, Østergaard, Søren, Monsellier, Élodie, Vincentelli, Renaud, Travé, Gilles   +14 more
openaire   +4 more sources

A pan-cancer compendium of 1,294 plasma cell-free DNA methylomes and fragmentomes enabling multicancer detection. [PDF]

Nat Cancer
Cell-free DNA analysis via methylation and fragmentation profiling has advanced minimally invasive cancer detection; however, broader application has been limited by small cohorts and inconsistent data processing.
Zeng Y, Abelman DD, Singhawansa A, Cheng N, Fang Y, Main SC, Bell E, Ye W, Luo P, Wilson SL, Stutheit-Zhao EY, Wong D, Znassi N, Chen K, Mohanraj S, Sanz-Garcia E, Notta F, Ghanekar A, Awadalla P, Lok BH, Hoffman MM, Kim RH, Zadeh G, De Carvalho DD, Bratman SV, Lupien M, Pugh TJ, He HH.   +27 more
europepmc   +2 more sources

Detection of Brain Cancer Using Genome-wide Cell-free DNA Fragmentomes. [PDF]

Cancer Discov
UNLABELLED: Diagnostic delays in patients with brain cancer are common and can impact patient outcome. Development of a blood-based assay for detection of brain cancers could accelerate brain cancer diagnosis.
Mathios D, Niknafs N, Annapragada AV, Bobeff EJ, Chiao EJ, Boyapati K, Boyapati K, Short S, Bartolomucci AL, Cristiano S, Koul S, Vulpescu NA, Ferreira L, Medina JE, Bruhm DC, Adleff V, Podstawka M, Stanisławska P, Park CK, Huang J, Gallia GL, Brem H, Mukherjee D, Caplan JM, Weingart J, Jackson CM, Lim M, Phallen J, Scharpf RB, Velculescu VE.   +29 more
europepmc   +2 more sources

Exploring per-base quality scores as a surrogate marker of cell-free DNA fragmentome [PDF]

Briefings in Bioinformatics
Volkov H, Raitses-Gurevich M, Grad M, Shlayem R, Leibowitz D, Rubinek T, Golan T, Shomron N.   +7 more
exaly   +2 more sources

Predicting disease recurrence in limited disease small cell lung cancer using cell-free DNA-based mutation and fragmentome analyses [PDF]

Translational Lung Cancer Research
Park S, Kang JK, Lee N, Lee SH, Kim HP, Kim SY, Kim TY, Kim H, Jung HA, Sun JM, Ahn JS, Ahn MJ, Park K.   +12 more
exaly   +2 more sources