Results 31 to 40 of about 291 (138)

Combining cell-free DNA fragmentomes and total tumour volume improves prognostication and tumour response evaluation in patients with colorectal cancer liver metastases. [PDF]

EBioMedicine
Background: Treatment decisions in patients with unresectable colorectal liver metastases (CRLM) are largely guided by radiological response to induction systemic therapy.
Crnovrsanin N, Zeeuw JM, Ali M, Kemna R, Alipanahi B, Lumbard K, Skidmore ZL, Rinaldi L, van 't Erve I, Wesdorp NJ, Huiskens J, van Steijn D, van Waesberghe JH, van den Bergh J, Nota I, Moos S, Bond MJG, Meiqari L, Huitink I, Giovannetti E, Stoker J, Verpalen I, van den Broek D, Meijer GA, Swijnenburg RJ, Punt CJA, Scharpf RB, Leal A, Dracopoli NC, Velculescu VE, Kok NFM, Kazemier G, Fijneman RJA.   +32 more
europepmc   +2 more sources

The Peptide MS/MS-Fragmentome: A Set of Predictable Fragment Ions with Highly Redundant Sequence Information [PDF]

, 2006
Upon low energy collision induced dissociation (CID), multiply protonated peptides generate a set of interdependent fragment ions detectable by MS/MS, the '[peptide]n+-fragmentome'.
Lehmann, Wolf D., Rappsilber, Juri, Wei, Junhua, Salek, Mojiborahman   +3 more
core   +1 more source

Fragmentomic cfDNA Patterns in Noninvasive Prenatal Testing and Beyond

Journal of Biomedicine and Translational Research, 2021
The release of fetoplacental cell-free DNA (cfDNA) into the maternal bloodstream opened up new avenues towards noninvasive prenatal testing (NIPT) for aneuploidies, hereditary DNA mutations and other pregnancy-related developmental disorders. Increasingly, cfDNA catches interest for its noninvasive screening value in other areas as well, including ...
Kavish Kohabir, Rob Wolthuis, Erik A. Sistermans   +2 more
openaire   +4 more sources

S225: CIRCULATING TUMOR DNA IS A PROGNOSTIC BIOMARKER AT BASELINE AND IMPROVES THE ACCURACY OF INTERIM PET IN CLASSIC HODGKIN LYMPHOMA

, 2022
HemaSphere, Volume 6, Issue S3, Page 126-127, June 2022.
M. C. Pirosa, A. Bruscaggin, L. Terzi di Bergamo, M. Salehi, K. Pini, V. Spina, S. Bocchetta, A. Condoluci, G. Forestieri, D. Piffaretti, J. Marques De Almeida, S. Annunziata, F. Bergesio, E. Borsatti, P. Bulian, S. Chauvie, C. Marco, D. T. Martina, G. Bernhard, M. Kurlapski, A. Moccia, R. Moia, A. Rinaldi, M. Rodari, G. Romanowicz, G. M. Sacchetti, A. Stasia, A. Stathis, G. Stüssi, I. Zangrilli, L. M. Larocca, A. Pinto, A. Santoro, F. Cavalli, E. Zucca, V. Gattei, J. M. Zaucha, C. Carlo‐Stella, S. Hohaus, G. Gaidano, L. Ceriani, D. Rossi   +41 more
wiley   +1 more source

Genomic and fragmentomic landscapes of cell-free DNA for early cancer detection. [PDF]

Nat Rev Cancer
Genomic analyses of cell-free DNA (cfDNA) in plasma are enabling noninvasive blood-based biomarker approaches to cancer detection and disease monitoring. Current approaches for identification of circulating tumour DNA typically use targeted tumour-specific mutations or methylation analyses.
Bruhm DC, Vulpescu NA, Foda ZH, Phallen J, Scharpf RB, Velculescu VE.   +5 more
europepmc   +4 more sources

Fragmentomics features of cell free DNA in eating disorders. [PDF]

Transl Psychiatry
Burova A, Verebi C, Lebrun N, Nectoux J, Boutonnet A, Duriez P, Gorwood P, Ramoz N, Bienvenu T.   +8 more
europepmc   +2 more sources

Detection and characterization of lung cancer using cell-free DNA fragmentomes [PDF]

Nature Communications, 2021
AbstractNon-invasive approaches for cell-free DNA (cfDNA) assessment provide an opportunity for cancer detection and intervention. Here, we use a machine learning model for detecting tumor-derived cfDNA through genome-wide analyses of cfDNA fragmentation in a prospective study of 365 individuals at risk for lung cancer. We validate the cancer detection
Dimitrios Mathios, Jakob Sidenius Johansen, Stephen Cristiano, Jamie E. Medina, Jillian Phallen, Klaus R. Larsen, Daniel C. Bruhm, Noushin Niknafs, Leonardo Ferreira, Vilmos Adleff, Jia Yuee Chiao, Alessandro Leal, Michael Noe, James R. White, Adith S. Arun, Carolyn Hruban, Akshaya V. Annapragada, Sarah Østrup Jensen, Mai-Britt Worm Ørntoft, Anders Husted Madsen, Beatriz Carvalho, Meike de Wit, Jacob Carey, Nicholas C. Dracopoli, Tara Maddala, Kenneth C. Fang, Anne-Renee Hartman, Patrick M. Forde, Valsamo Anagnostou, Julie R. Brahmer, Remond J. A. Fijneman, Hans Jørgen Nielsen, Gerrit A. Meijer, Claus Lindbjerg Andersen, Anders Mellemgaard, Stig E. Bojesen, Robert B. Scharpf, Victor E. Velculescu   +37 more
openaire   +6 more sources

Fragmentomics of natural peptide structures

Biochemistry (Moscow), 2009
Natural fragmentation of peptide and other chemical structures is well known. They are a significant object of biochemical investigations. In this connection, the bases and determination are given for the notion of the "fragmentome" as a set of all fragments of a single substance, as well as for global fragmentome of all chemical components of living ...
openaire   +4 more sources

AGE-ASSOCIATED VARIABILITY OF CIRCULATING FREE DNA CHARACTERISTICS: GENOME-WIDE ANALYSIS

Journal of Bioinformatics and Genomics
The fragments of circulating free DNA (cfDNA) found in plasma are formed due to the genomic DNA degradation during cellular death. The present study is the first research of age-associated variability of cfDNA characteristics performed on the group of ...
Meshkov I.O., Remizova J.A., Makarova A.S., Primova A.A., Petrova V.A., Bukhanova A.A., Kumar N.A., Ivashechkin A.A., Makhotenko A.V., Snigir E.A., Makarov V.V., Yudin V.S., Keskinov A.A., Yudin S.M.   +13 more
doaj   +1 more source

Fragmentomics features of ovarian cancer

International Journal of Cancer
AbstractOvarian cancer (OC) is a major cause of cancer mortality in women worldwide. Due to the occult onset of OC, its nonspecific clinical symptoms in the early phase, and a lack of effective early diagnostic tools, most OC patients are diagnosed at an advanced stage.
Xiaopei Chao, Zhentian Kai, Huanwen Wu, Jing Wang, Xiaojing Chen, Haiqi Su, Xiao Shang, Ruijue Lin, Lisha Huang, Hongsheng He, Jinghe Lang, Lei Li   +11 more
openaire   +2 more sources