Results 41 to 50 of about 881 (146)

Correspondence to editorial on “Aberrant fragmentomic features of circulating cell-free mitochondrial DNA enable early detection and prognosis prediction of hepatocellular carcinoma” [PDF]

Clinical and Molecular Hepatology
Yang Liu, Fan Peng, Siyuan Wang, Jinliang Xing   +3 more
doaj   +2 more sources

Real‐time analysis of the cancer genome and fragmentome from plasma and urine cell‐free DNA using nanopore sequencing

EMBO Molecular Medicine, 2023
Cell‐free DNA (cfDNA) can be isolated and sequenced from blood and/or urine of cancer patients. Conventional short‐read sequencing lacks deployability and speed and can be biased for short cfDNA fragments.
Ymke van der Pol, Normastuti Adhini Tantyo, Nils Evander, Anouk E Hentschel, Birgit MM Wever, Jip Ramaker, Sanne Bootsma, Marieke F Fransen, Kristiaan J Lenos, Louis Vermeulen, Famke L Schneiders, Idris Bahce, Jakko A Nieuwenhuijzen, Renske DM Steenbergen, D Michiel Pegtel, Norbert Moldovan, Florent Mouliere   +16 more
doaj   +1 more source

Cell-Free DNA Fragmentation Patterns in a Cancer Cell Line

Diagnostics, 2022
Unique bits of genetic, biological and pathological information occur in differently sized cell-free DNA (cfDNA) populations. This is a significant discovery, but much of the phenomenon remains to be explored. We investigated cfDNA fragmentation patterns
Vida Ungerer, Abel J. Bronkhorst, Carsten Uhlig, Stefan Holdenrieder   +3 more
doaj   +1 more source

Epigenetic analysis of cell-free DNA by fragmentomic profiling

Proceedings of the National Academy of Sciences, 2022
Cell-free DNA (cfDNA) fragmentation patterns contain important molecular information linked to tissues of origin. We explored the possibility of using fragmentation patterns to predict cytosine-phosphate-guanine (CpG) methylation of cfDNA, obviating the use of bisulfite treatment and associated risks of DNA degradation.
Qing Zhou, Guannan Kang, Peiyong Jiang, Rong Qiao, W. K. Jacky Lam, Stephanie C. Y. Yu, Mary-Jane L. Ma, Lu Ji, Suk Hang Cheng, Wanxia Gai, Wenlei Peng, Huimin Shang, Rebecca W. Y. Chan, Stephen L. Chan, Grace L. H. Wong, Linda T. Hiraki, Stefano Volpi, Vincent W. S. Wong, John Wong, Rossa W. K. Chiu, K. C. Allen Chan, Y. M. Dennis Lo   +21 more
openaire   +2 more sources

At the dawn: cell-free DNA fragmentomics and gene regulation [PDF]

British Journal of Cancer, 2021
AbstractEpigenetic mechanisms play instrumental roles in gene regulation during embryonic development and disease progression. However, it is challenging to non-invasively monitor the dynamics of epigenomes and related gene regulation at inaccessible human tissues, such as tumours, fetuses and transplanted organs.
openaire   +2 more sources

Profiling disease and tissue-specific epigenetic signatures in cell-free DNA

Journal of Laboratory Medicine, 2022
Programmed cell death, accidental cell degradation and active extrusion constantly lead to the release of DNA fragments into human body fluids from virtually all cell and tissue types.
Oberhofer Angela, Bronkhorst Abel Jacobus, Ungerer Vida, Holdenrieder Stefan   +3 more
doaj   +1 more source

Early detection of renal cell carcinoma: a novel cell-free DNA fragmentomics-based liquid biopsy assay [PDF]

ESMO Open
H Bao
exaly   +2 more sources

Combining variant detection and fragment length analysis improves detection of minimal residual disease in postsurgery circulating tumour DNA of stage II–IIIA NSCLC patients

Molecular Oncology, 2022
Stage II–IIIA nonsmall cell lung cancer (NSCLC) patients receive adjuvant chemotherapy after surgery as standard‐of‐care treatment, even though only approximately 5.8% of patients will benefit.
Daan C. L. Vessies, Milou M. F. Schuurbiers, Vincent van derNoort, Irene Schouten, Theodora C. Linders, Mirthe Lanfermeijer, Kalpana L. Ramkisoensing, Koen J. Hartemink, Kim Monkhorst, Michel M. van denHeuvel, Daan van denBroek   +10 more
doaj   +1 more source

Cell-free DNA Fragmentomics Assay to Discriminate the Malignancy of Breast Nodules and Evaluate Treatment Response [PDF]

Genomics, Proteomics and Bioinformatics
Hua Bao, Tianyi Qian, Ziqi Jia
exaly   +2 more sources

Fragmentation patterns and personalized sequencing of cell‐free DNA in urine and plasma of glioma patients

EMBO Molecular Medicine, 2021
Glioma‐derived cell‐free DNA (cfDNA) is challenging to detect using liquid biopsy because quantities in body fluids are low. We determined the glioma‐derived DNA fraction in cerebrospinal fluid (CSF), plasma, and urine samples from patients using ...
Florent Mouliere, Christopher G Smith, Katrin Heider, Jing Su, Ymke van der Pol, Mareike Thompson, James Morris, Jonathan C M Wan, Dineika Chandrananda, James Hadfield, Marta Grzelak, Irena Hudecova, Dominique‐Laurent Couturier, Wendy Cooper, Hui Zhao, Davina Gale, Matthew Eldridge, Colin Watts, Kevin Brindle, Nitzan Rosenfeld, Richard Mair   +20 more
doaj   +1 more source