Results 61 to 70 of about 60,935 (313)

Antioxidant and Anti-Arthritic Activities of Green Seaweed Halimeda tuna Methanolic Extract

Squalen
Seaweed contains various bioactive compounds rich in pharmacological potentials, such as antioxidants and anti-arthritic. This study aims to determine the antioxidant and anti-arthritic activities of the methanolic extract of Halimeda tuna. Halimeda tuna
Mohamad Gazali, Aden Nurin Fatimah, Amir Husni, Nurjanah Nurjanah, Zuriat Zuriat, Rina Syafitri   +5 more
doaj   +1 more source

Reprogramming Tumor‐Associated Macrophages via Targeted NAT10 Inhibition to Enhance Colorectal Cancer Immunotherapy

Advanced Science, EarlyView.
This study presents the sono‐sensitive nanorobot Sono@NAT10, which targets NAT10 condensates to reprogram tumor‐associated macrophages in colorectal cancer. By reducing the acetylation level of SRSF2 protein and activating HDAC10, Sono@NAT10 promotes M1 polarization, suppresses tumor progression, and strengthens immunotherapy. The approach demonstrates
Jiahao Zhu, Benjie Xu, Rui Hu, Bo Yang, Peipei Shen, Yu Xu, Xiaojun Zhang, Danqi Qian, Gang Wu, Shengjun Ji, Yutian Zhao, Ke Gu   +11 more
wiley   +1 more source

Microcondensate‐Mediated Intracellular Infusion of mRNA Across the Plasma Membrane

Angewandte Chemie, EarlyView.
The delivery of mRNA without lipid nanoparticles remains challenging. FcB(L17E)3‐driven microcondensates with nucleic acids, aided by short ssDNA, enable coacervate formation, actin‐dependent cytosolic infusion, and in vivo protein expression, offering a potential platform for next‐generation mRNA therapeutics and vaccination.
Yoshimasa Kawaguchi, Ayumi Kikkawa, Seigo Kimura, Hiroshi Abe, Shiroh Futaki   +4 more
wiley   +2 more sources

MLKS2 is an ARM domain and F-actin-associated KASH protein that functions in stomatal complex development and meiotic chromosome segregation

Nucleus, 2019
The linker of nucleoskeleton and cytoskeleton (LINC) complex is an essential multi-protein structure spanning the eukaryotic nuclear envelope. The LINC complex functions to maintain nuclear architecture, positioning, and mobility, along with specialized ...
Hardeep K. Gumber, Joseph F. McKenna, Andrea F. Tolmie, Alexis M. Jalovec, Andre C. Kartick, Katja Graumann, Hank W. Bass   +6 more
doaj   +1 more source

Engineered Multifunctional Hydrogel Delivering Novel CBX7 Inhibitor Modulates Cuproptosis Via Liquid–Liquid Phase Separation to Restore Cardiac Function in Aged Myocardial Infarction

Advanced Science, EarlyView.
An age‐adapted therapy pairs δ‐Amyrenone, a CBX7 inhibitor, with an alginate hydrogel (CSAδ) to rescue infarcted elderly hearts. CSAδ disrupts CBX7–ATP7A liquid–liquid phase separation, restores ATP7A trafficking and copper efflux, suppresses cuproptosis, supplies oxygen, scavenges ROS, promotes M2 polarization, supports angiogenesis, and enhances ...
Jun Liu, Peng Qu, Jiao Shi, Tingting Liang, Yao Gu, Xue Li, Cui Ma, Danyang Zhao, Feila Liu, Qi Liang, Panke Cheng, Qian Lei   +11 more
wiley   +1 more source

Membrane‐Penetrating Molecular Device Based on a Triplex Containing Acyclic L‐Threoninol Nucleic Acid Functionalized with Cholesterol

Angewandte Chemie, EarlyView.
A membrane‐penetrating molecular device composed of triplex containing cholesterol‐modified acyclic L‐threoninol nucleic acid (L‐aTNA) was achieved. This device is applied to a photo‐triggered signal transduction system functioning on giant unilamellar vesicles. Abstract Membrane‐penetrating molecular devices are valuable biological tools.
Kaifu Liu, Hiroyuki Asanuma, Keiji Murayama   +2 more
wiley   +2 more sources

Comparison of antioxidant activity of extracts of hop leaves harvested in different years

Herba Polonica, 2019
Introduction: Hop (Humulus lupulus L.) is a common plant in Europe, with many beneficial health effects. In addition to the use in brewing, hops are a valuable source of active substances used in conventional and folk medicine, such as humulones and ...
Muzykiewicz Anna, Nowak Anna, Zielonka-Brzezicka Joanna, Florkowska Katarzyna, Duchnik Wiktoria, Klimowicz Adam   +5 more
doaj   +1 more source

Aktivitas Antioksidan Ekstrak Etanol Buah Merah (Pandanus conoideus Lam.) dengan Metode FRAP

Window of Health, 2019
Buah merah (Pandanus conoideus Lam.) merupakan tanaman endemik yang tumbuh di wilayah Papua. Berdasarkan penelitian sebelumnya buah merah mengandung beberapa senyawa aktif dengan kadar yang cukup tinggi, diantaranya karotenoid, tokoferol, betakaroten, α ...
Rheytno Asdin Wabula, Seniwati Dali, Harti Widiastuti   +2 more
doaj   +1 more source

Analysis of membrane-localized binding kinetics with FRAP

European Biophysics Journal, 2008
Interactions between plasma membrane-associated proteins on interacting cells are critical for many important biological processes. Few experimental techniques, however, can accurately determine the association and the dissociation rates between such interacting pairs when the two molecules diffuse on apposing membranes or lipid bilayers. In this study,
Dushek, O, Das, R, Coombs, D
openaire   +2 more sources

BRIGHT Enables High‐SNR Live‐Cell Imaging of Non‐Repetitive Sequences via Bivalent Fluorescent Nanobody‐Mediated Cascade‐Dependent Illumination

Advanced Science, EarlyView.
BRIGHT is a newly developed live‐cell imaging system that integrates cascade amplification with background denoising through the bivalent binding capability and antigen‐dependent stability of a bivalent fluorescent nanobody targeting ALFA peptides.
Lei Feng, Tao Huang, Yanxi Han, Meng Tian, Duo Wang, Zilong Mei, Yu Ma, Yingshuo Ma, Jinming Li, Rui Zhang   +9 more
wiley   +1 more source