Results 101 to 110 of about 9,850,197 (175)

Decreased diffusivity along the perivascular spaces in bipolar disorder: an MRI-based cross-sectional and Mendelian randomization study

Translational Psychiatry
The pathophysiology of bipolar disorder (BD) remains unclear. We investigated whether diffusion tensor imaging along perivascular spaces (DTI-ALPS), a putative MRI marker of glymphatic function, is altered in BD and whether this index relates to ...
Zhuohui Chen, Ziwei Teng, Yan Qiu, Sujuan Li, Xuelei Xu, Min Yang, Jindong Chen, Dong Yang, Hao Li   +8 more
doaj   +1 more source

Gray matter microstructure alterations with excess extra-cellular free water contribute to cognitive dysfunction in bipolar disorder: A comparative analysis with white matter pathology

NeuroImage
Background: Bipolar disorder (BD) is a chronic mental disorder involving cognitive dysfunction. Imaging studies reveal reduced cortical thickness and impaired white matter integrity in BD; however, the biological pathophysiology underlying cognitive ...
Yasuhito Nagai, Toshimasa Fujimura, Wataru Uchida, Rinako Iseki, Koji Kamagata, Shigeki Aoki, Tadafumi Kato   +6 more
doaj   +1 more source

White matter abnormalities in patients with focal cortical dysplasia revealed by diffusion tensor imaging (DTI) analysis in a voxelwise approach

Frontiers in Neurology, 2012
Background: Diffusion tensor imaging (DTI) allows the analysis of changes in microstructure, through the quantification of the spread and direction of water molecules in tissues.
Viviane Carvalho Fonseca, Clarissa Lin Yasuda, Guilherme Garlipp Tedeschi, Luiz Eduardo eBetting, Fernando eCendes   +4 more
doaj   +1 more source

Association of glymphatic dysfunction, free water, white matter integrity and long-term memory performance in aging autistic adults

Molecular Autism
Background Autistic adults are at elevated risk of accelerated cognitive aging and Alzheimer’s disease and related dementias (ADRD), yet the underlying neurobiological mechanisms remain poorly understood. Dysfunction in the glymphatic system—a brain-wide
Yuanchao Zhang, Edward Ofori, Kewei Chen, Samantha A. Harker, Manuela Velez, Stephen Gallegos, Katie Grabeel, Faith Johnson, Leslie Baxter, Bryan Woodruff, B. Blair Braden   +10 more
doaj   +1 more source

Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease

Frontiers in Neuroscience
ObjectiveWhite matter hyperintensities (WMH) are common in cerebral small vessel disease (CSVD) and have been linked to an increased risk of stroke and cognitive impairment.
Weishun Feng, Xinjun Lei, Xinbin Wang, Shida Xu, Zhihua Xu   +4 more
doaj   +1 more source

Glymphatic system dysfunction in temporal lobe epilepsy with hippocampal sclerosis: MRI-based evaluation of circulatory markers and disease progression

Frontiers in Neuroscience
ObjectivesIn this study, several MRI-derived glymphatic markers were utilized to evaluate alterations in glymphatic system (GS) function in patients with temporal lobe epilepsy and hippocampal sclerosis (TLE-HS).Methodswe assessed 160 participants ...
Yingpeng Kuang, Dingwen Hu, Hui Chu, Rongyu Zhang, Ziyu Diao, Kun Wang, Xiaomei Yue, Yuna Chen, Shijun Qiu, Shijun Qiu, Jie An, Jie An   +11 more
doaj   +1 more source

White matter microstructure and cognitive decline in subacute ischemic stroke: Insights from free water imaging and glymphatic dysfunction

Brain Research Bulletin
Objective: This study aimed to investigate white matter microstructural changes and their relationship with cognitive function in patients with subacute ischemic stroke (IS) using free water diffusion tensor imaging (FW-DTI) and tract-based spatial ...
Yue Qin, Xin Li, Lei Wang, Yanqiang Qiao, Liyao Liu, Juan Tian, Dayong Jin, Yinhu Zhu, Ming Zhang   +8 more
doaj   +1 more source

Association of choroid plexus volume, glymphatic system markers, and cognitive impairment in HIV-associated neurocognitive disorders

BMC Infectious Diseases
Background Although combined antiretroviral therapy (cART) effectively suppresses viral replication, HIV-associated neurocognitive disorders (HAND) remain prevalent.
Wenru Gong, Zhongkai Zhou, Ran Wang, Ruichen Ren, Chao Yuan, Lingling Zhao, Wei Wang, Hongjun Li   +7 more
doaj   +1 more source

Glymphatic dysfunction as an imaging biomarker for cognitive impairment in patients with β-thalassemia major: A multimodal MRI study

European Journal of Radiology Open
Background and purpose: Cerebral lymphatic abnormalities have been associated with neurodegenerative processes. However, brain glymphatic system and its role in cognitive impairment in β-thalassemia major (β-TM) remain unknown.
Xingye Yang, Meiru Bu, Xi Deng, Haifeng Zheng, Chengli Wu, Wei Cui, Muliang Jiang, Bihong T. Chen   +7 more
doaj   +1 more source

Water-Related Bills in the 2008 Virginia General Assembly

, 2008
The 2008 Virginia General Assembly session opened January 9 and adjourned March 13. Work on the biennial state budget required a few additional days beyond the scheduled adjournment date of March 8.
Virginia Water Resources Research Center
core