Results 111 to 120 of about 12,150 (200)

Distinguishing Early from Late Mild Cognitive Impairment Using Magnetic Resonance Free-Water Diffusion Tensor Imaging

NeuroSci
Mild Cognitive Impairment (MCI) is a transitional stage between normal aging and Alzheimer’s disease. Differentiating early MCI (EMCI) from late MCI (LMCI) is crucial for early diagnosis and intervention.
Maurizio Bergamino, Molly M. McElvogue, Ashley M. Stokes, Alzheimer’s Disease Neuroimaging Initiative   +3 more
doaj   +1 more source

Global OCD Study - DW-MRI - Free Water Content

Diffusion weighted Magnetic Resonance Imaging (DW-MRI) measures the averaged water diffusion properties within a voxel (millimeter scale) that comprises several compartments.
Marcelo Q. Hoexter, Roseli Gedanke Shavitt, Christine Lochner, Chris Vriend, Janardhan Y.C. Reddy, Ganesan Venkatasubramanian, Petra J W Powels, Odile van den Heuvel, Maria Concepcion Garcia Otaduy, Marcelo Camargo Batistuzzo, Blair Simpson   +10 more
core   +1 more source

White matter structural changes in the visual pathway of thyroid-associated ophthalmopathy patients: a free water and multi-shell diffusion imaging study

Frontiers in Neurology
BackgroundCompared to single-shell diffusion tensor imaging (DTI), free water (FW) and neurite orientation dispersion and density imaging (NODDI) offer a more comprehensive evaluation of microstructural alterations in cerebral white matter (WM ...
Jiaqi Yao, Jiaqi Yao, Xinjian Lu, Jingxu Ma, Lu Hao, Ying Liu, Xiaopan Huang, Jun Liu, Boding Tong   +8 more
doaj   +1 more source

Towards Clinical Translation of Intravoxel Incoherent Motion MRI: Acquisition and Analysis Consensus Recommendations

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1782-1801, June 2026.
ABSTRACT Intravoxel incoherent motion (IVIM) MRI allows for simultaneous assessment of tissue microcirculation (perfusion) and diffusion of water. In single‐center studies, IVIM has shown great potential for diagnosis, treatment outcome prediction, and treatment monitoring for many different diseases and organs.
Eric E. Sigmund, Susanne S. Rauh, Mami Iima, Christian Federau, Diego Hernando, Oscar Jalnefjord, Jacobus F. A. Jansen, Jonas Jasse, Neil Peter Jerome, Misha P. T. Kaandorp, Sila Kurugol, Frederik B. Laun, Mira M. Liu, Alexandra Ljimani, Thoralf Niendorf, David A. Reiter, Mohammed Salman Shazeeb, Amita Shukla‐Dave, Julia Stabinska, Andreas Wetscherek, Peter T. While, Dan Wu, Denis Le Bihan, Oliver J. Gurney‐Champion   +23 more
wiley   +1 more source

Free water as a potential mediator linking basal ganglia peri-vascular spaces to white matter hyperintensities in cerebral small vessel disease

Frontiers in Neuroscience
ObjectiveWhite matter hyperintensities (WMH) are common in cerebral small vessel disease (CSVD) and have been linked to an increased risk of stroke and cognitive impairment.
Weishun Feng, Xinjun Lei, Xinbin Wang, Shida Xu, Zhihua Xu   +4 more
doaj   +1 more source

The Role of Magnetic Resonance Spectroscopy (MRS), Diffusion‐Tensor‐Imaging (DTI) and Structural MRI in the Alzheimer's Disease and Mild Cognitive Impairment Diagnosis: A Review

Journal of Magnetic Resonance Imaging, Volume 63, Issue 6, Page 1509-1545, June 2026.
ABSTRACT Alzheimer's disease (AD) is one of the most common neurological disorders affecting older adults, with approximately 7.2 million cases only in the United States. This number is projected to increase to 13.8 million in the United States by 2060, leading to increased expenditures for healthcare, long‐term care and hospice services. Consequently,
Valentina Zecca, Gianmauro Palombelli, Nicola Vanacore, Rossella Canese   +3 more
wiley   +1 more source

Structural Adaptive Smoothing in Diffusion Tensor Imaging: The R Package dti

Diffusion weighted imaging has become and will certainly continue to be an important tool in medical research and diagnostics. Data obtained with diffusion weighted imaging are characterized by a high noise level.
Jörg Polzehl, Karsten Tabelow
core  

Assessment of Optimal T1/T2‐Weighted Combinations for Myelin Sensitivity: Effects of Echo Time and Exponents

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3176-3186, June 2026.
ABSTRACT Purpose The aim of this study is to improve the traditional T1‐weighted (T1w) over T2‐weighted (T2w) ratio as a proxy for myelin by investigating the optimal T2w TE and combination of exponent‐weighted T1w and T2w images (T1wx1/T2wx2). Methods T1w and T2w Gradient And Spin Echo (GRASE) data were acquired from 14 volunteers, 6 of whom had a ...
Simone Monachino, Gerhard S. Drenthen, Lis J. M. van den Boogaard, Marcel Breeuwer, Catarina Dinis Fernandes, Oliver H. H. Gerlach, Svitlana Zinger, Jacobus F. A. Jansen   +7 more
wiley   +1 more source

Complementary Sensitivity of Fixed‐Time and Fixed‐Oscillation Regimes to Exchange and Structural Disorder in the Human Brain Revealed Using Oscillating‐Gradient Diffusion MRI With Ultra‐Strong Gradients

Magnetic Resonance in Medicine, Volume 95, Issue 6, Page 3429-3444, June 2026.
ABSTRACT Purpose Oscillating‐gradient spin‐echo (OGSE) diffusion MRI probes cell geometry and membrane integrity through the frequency‐dependence of kurtosis, but prior studies have reported inconsistent findings depending on how frequency is varied. We compared frequency‐dependent kurtosis in the human brain under two regimes: varying frequency with ...
Dongsuk Sung, Kwok‐Shing Chan, Julianna Gerold, Wen Zhong, Jialan Zheng, Qiyuan Tian, Hua Guo, Susie Y. Huang, Hong‐Hsi Lee   +8 more
wiley   +1 more source

Cognitive impairment and vulnerability of cholinergic brain network in the Alzheimer’s continuum: free-water imaging based on diffusion tensor imaging

Frontiers in Neuroscience
BackgroundIncreased extracellular free water (FW) is considered to provide better pathophysiological information than conventional diffusion tensor imaging (DTI) metrics.
Simin Zhao, Yuting Nie, Lulu Wen, Xinzuo Qin, Liyuan Huang, Changbiao Chu, Miao Qu, Miao Qu   +7 more
doaj   +1 more source