Results 41 to 50 of about 566,112 (285)

Laser-Induced Linear Electron Acceleration in Free Space [PDF]

, 2016
Linear acceleration in free space is a topic that has been studied for over 20 years, and its ability to eventually produce high-quality, high energy multi-particle bunches has remained a subject of great interest.
Carbajo, Sergio, Fallahi, Arya, Hong, Kyung-Han, Joannopoulos, John D., Kaminer, Ido, Kärtner, Franz X., Piot, Philippe, Soljačić, Marin, Wong, Liang Jie   +8 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

MHz X-ray photon correlation spectroscopy using an acoustic levitator at the European XFEL

Journal of Synchrotron Radiation
The structural and dynamical properties of soft-matter systems play an important role in crystallization and nucleation theory. Despite their significance, the dynamical properties are still poorly understood because of experimental constraints and the ...
Wonhyuk Jo, Johannes Möller, Jörg Hallmann, James Wrigley, Jan-Etienne Pudell, Ulrike Boesenberg, Felix Brausse, Angel Rodriguez-Fernandez, Alexey Zozulya, Roman Shayduk, Anders Madsen   +10 more
doaj   +1 more source

Spectral phase control of interfering chirped pulses for high-energy narrowband terahertz generation

Nature Communications, 2019
Optical generation of terahertz radiation is needed for many applications, but gaining high efficiency is still a challenge. The authors report a method to overcome dispersion effects in interfering chirp pulses used for THz pulse production by tuning ...
Spencer W. Jolly, Nicholas H. Matlis, Frederike Ahr, Vincent Leroux, Timo Eichner, Anne-Laure Calendron, Hideki Ishizuki, Takunori Taira, Franz X. Kärtner, Andreas R. Maier   +9 more
doaj   +1 more source

Towards Realistic Simulations of Macromolecules Irradiated under the Conditions of Coherent Diffraction Imaging with an X-ray Free-Electron Laser

Photonics, 2015
Biological samples are highly radiation sensitive. The rapid progress of their radiation damage prevents accurate structure determination of single macromolecular assemblies in standard diffraction experiments. However, computer simulations of the damage
Beata Ziaja, Zoltan Jurek, Nikita Medvedev, Vikrant Saxena, Sang-Kil Son, Robin Santra   +5 more
doaj   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source

Controlled beams of shock-frozen, isolated, biological and artificial nanoparticles

Structural Dynamics, 2020
X-ray free-electron lasers promise diffractive imaging of single molecules and nanoparticles with atomic spatial resolution. This relies on the averaging of millions of diffraction patterns of identical particles, which should ideally be isolated in the ...
Amit K. Samanta, Muhamed Amin, Armando D. Estillore, Nils Roth, Lena Worbs, Daniel A. Horke, Jochen Küpper   +6 more
doaj   +1 more source

Quantum theory of SASE FEL [PDF]

, 2005
We describe a free-electron laser (FEL) in the Self-Amplified Spontaneous Emission (SASE) regime quantizing the electron motion and taking into account propagation effects. We demonstrate quantum purification of the SASE spectrum, i.e.
Andruszkow, Arecchi, Baier, Bernstein, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Bonifacio, Burnham, G.R.M. Robb, Grover, Kim, Kondratenko, Kroll, Milton, Moore, Moore, N. Piovella, Orzechowski, Piovella, Piovella, Preparata, R. Bonifacio, Saldin, Wang, Yu   +33 more
core   +2 more sources

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

VUV and X-ray coherent light with tunable polarization from single-pass free-electron lasers

, 2011
Tunable polarization over a wide spectral range is a required feature of light sources employed to investigate the properties of local symmetry in both condensed and low-density matter.
A. Kondratenko, A. Yariv, B. Diviacco, B. Mahieu, C. Spezzani, E. Allaria, E. Ferrari, E. Karantzoulis, G. De Ninno, G. Geloni, J. C. Sutherland, J. D. Jackson, M. Coreno, M. Vento, R. Walker   +14 more
core   +1 more source