Results 71 to 80 of about 876,006 (355)

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

Molecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero, Alejandro Belmonte‐Fernández, Mónica González‐Moreno, Laura Rodríguez‐Cordero, Begoña Pérez‐Valderrama, Joaquín Herrero‐Ruíz, Francisco Romero, Carmen Sáez, Miguel Á. Japón   +8 more
wiley   +1 more source

Effect of Temperature of Two-Year Storage of Varietal Honeys on 5-Hydroxymethylfurfural Content, Diastase Number, and CIE Color Coordinates

Agriculture
This study aimed to evaluate the effect of two-year storage of varietal honeys (buckwheat, linden, rapeseed, honeydew, and multifloral) at various temperatures (4 °C, −18 °C, −40 °C, and −80 °C) on the content of 5-hydroxymethylfurfural (5-HMF), diastase
Monika Kędzierska-Matysek, Anna Teter, Tomasz Daszkiewicz, Barbara Topyła, Piotr Skałecki, Piotr Domaradzki, Mariusz Florek   +6 more
doaj   +1 more source

Criopreservação do sêmen de curimba (Prochilodus lineatus) mediante adição de diferentes diluidores, ativadores e crioprotetores Cryopreservation of curimba (Prochilodus lineatus) semen after addition of different diluters, activators and cryoprotectants

Revista Brasileira de Zootecnia, 2007
Amostras de sêmen de cinco espécimes de Prochilodus lineatus (Valencienes, 1847) foram utilizadas para avaliação dos efeitos tóxicos e crioprotetores de seis soluções à base de BTS (Beltsville Thawing Solution®) 4,5% enriquecidas com metanol e DMSO nas ...
Luis David Solis Murgas, Aléssio Batista Miliorini, Rilke Tadeu Fonseca de Freitas, Gilmara Junqueira Machado Pereira   +3 more
doaj   +1 more source

Repeatability of a Commercially Available ELISA Test for Determining the Herd-Level Salmonella enterica subsp. enterica Serovar Dublin Status in Dairy Herds Using Bulk Milk

Frontiers in Veterinary Science, 2020
An Enzyme-Linked Immunosorbent Assay (ELISA) is currently available for detection of antibodies against Salmonella Dublin in bovine milk. However, when used in a surveillance program, samples may undergo various storage conditions.
Maryse Michèle Um, Maryse Michèle Um, Maryse Michèle Um, Marie-Hélène Castonguay, Khalie Mahamad Amine, Julie Giguère, Isabelle Morin, Simon Dufour, Simon Dufour, Simon Dufour   +9 more
doaj   +1 more source

A MYB-related transcription factor from peanut, AhMYB30, improves freezing and salt stress tolerance in transgenic Arabidopsis through both DREB/CBF and ABA-signaling pathways [PDF]

, 2023
Na Chen, Lijuan Pan, Zhen Yang, Maowen Su, Jing Xu, Xiao Jiang, Xiangzhen Yin, Tong Wang, Feifei Wan, Xiaoyuan Chi   +9 more
openalex   +1 more source

Experimental study of the role of physicochemical surface processing on the IN ability of mineral dust particles [PDF]

, 2011
During the measurement campaign FROST 2 (FReezing Of duST 2), the Leipzig Aerosol Cloud Interaction Simulator (LACIS) was used to investigate the influence of various surface modifications on the ice nucleating ability of Arizona Test Dust (ATD ...
Buchholz, Angela, Bundke, Ulrich, Clauss, Tina, DeMott, Paul J., Hartmann, Susan, Kiselev, Alexei, Mentel, Thomas F., Mikhailov, Eugene, Niedermeier, Dennis, Petters, Markus D., Reimann, Bernd, Reitz, Paul, Schneider, Johannes, Shaw, Raymond A., Sierau, Berko, Stetzer, Olaf, Stratmann, Frank, Sullivan, Ryan C., Wex, Heike   +18 more
core   +4 more sources

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

Molecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts, Senada Koljenović, Elise Daems, Karolien De Wael, Marc Peeters, Léon C. van Kempen, Greetje Vanhoutte, Karen Zwaenepoel, Timon Vandamme   +8 more
wiley   +1 more source

Abstract P-27: Computational Modeling of Tubulin Protofilament Relaxation during Rapid Freezing [PDF]

International Journal of Biomedicine, 2019
Background: Over the recent years, there has been a burst of ground-breaking studies, based on cryo-EM. They shed light on various intracellular structures, including microtubules (Alushin et al., 2014; Manka and Moores, 2018).
Dmitrii S. Vinogradov, Evgeniy V. Ulyanov, J. Richard McIntosh, Fazoil I. Ataullakhanov, Nikita B. Gudimchuk   +4 more
doaj   +1 more source

Investigating the cell of origin and novel molecular targets in Merkel cell carcinoma: a historic misnomer

Molecular Oncology, EarlyView.
This study indicates that Merkel cell carcinoma (MCC) does not originate from Merkel cells, and identifies gene, protein & cellular expression of immune‐linked and neuroendocrine markers in primary and metastatic Merkel cell carcinoma (MCC) tumor samples, linked to Merkel cell polyomavirus (MCPyV) status, with enrichment of B‐cell and other immune cell
Richie Jeremian, Sriraam Sivachandran, Melissa Galati, Brandon Ramchatesingh, Hibo Rijal, Johnny Hanna, Elena Netchiporouk, May Chergui, Margaret Redpath, Samy Abou Setah, Ivan V. Litvinov   +10 more
wiley   +1 more source

Universality of Tip Singularity Formation in Freezing Water Drops [PDF]

, 2014
A drop of water deposited on a cold plate freezes into an ice drop with a pointy tip. While this phenomenon clearly finds its origin in the expansion of water upon freezing, a quantitative description of the tip singularity has remained elusive.
Brunet, Philipe, Colinet, Pierre, Enriquez, Oscar R., Marin, Alvaro G., Snoeijer, Jacco H.   +4 more
core   +2 more sources