Results 121 to 130 of about 1,680,668 (311)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

TO MARKET, TO MARKET TO SELL FRESH PRODUCE; BUT WHERE? AND WHEN? [PDF]

Agribusiness,
Riggins, Steven K., Stegelin, Forrest E., Williamson, Lionel   +2 more
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

Molecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute, Madeleine Birgersson, Paolo Ceriani, Margareta Wilhelm, Ourania N Kostopoulou   +4 more
wiley   +1 more source

SUPPLY CHAIN MANAGEMENT IN THE FRESH PRODUCE INDUSTRY: A MILE TO GO? [PDF]

We investigate the factors that influence vertical coordination in the fresh produce industry. Elaborating on the concept of governance structure, price and non-price coordination systems will be distinguished.
Zuurbier, Peter J.P.
core   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Market Power in Direct Marketing of Fresh Produce: Community Supported Agriculture Farms [PDF]

CSA farms establish a loyal customer base and, potentially, market power. A new empirical industrial organization (NEIO) approach and survey data from Northeast CSA farms are used to determine whether CSA farms have market power and the extent to which ...
Daniel A. Lass, Nathalie Lavoie, T. Robert Fetter   +2 more
core  

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Open letter: Six steps towards a national plan of protected horticulture—A call for coordinated action

Plants, People, Planet
The UK's growing reliance on imports and rising climate risks highlight the need to expand protected horticulture as a secure, low‐carbon source of fruit and vegetables.
Sven Batke, David Barker, Darrell Jones, Jack Farmer, Noel O'Leary, Phil Morley, John Walgate, Lee Stiles, Luke Hibberd, Jason Perrott, Alfie Russell, Ralph Weir, Nathanael Dannenberg, Robert Woods, Oliver Green, Stuart Gibson, Laura Pearson, Stephanie Tarvin, David Rowley, Bethan Mcilroy, Su Varma, Paul Rutten, Joe Shepherdson, Kathryn Fletcher, Anthony Paul Sangwine, Helen Sessions, Toni Borella, Samuel Harris, Nathan Thomas, Charlie Guy, Ruth Vichos, Esther deBeer   +31 more
doaj   +1 more source

Baseline Microbial Assessment of Fresh Produce [PDF]

Currently no standards or requirements exist for microbial food safety for space grown produce (fresh plant foods). Without standards it is difficult to assess produce handling and sanitization options for the ISS and future exploration missions.
Hummerick, M. E., Johnson, C. M., Massa, G. D., Spencer, L., Wheeler, R. M.   +4 more
core   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source