Results 111 to 120 of about 489,119 (312)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
THE FINANCIAL FEASIBILITY OF ESTABLISHING A FRESH PRODUCE PACKING HOUSE IN JORDAN
Historically, Jordan's traditional markets for fresh produce have been the Persian Gulf countries. However, these exports have declined in recent years and new markets in Europe have been tapped.
Hattar, Raed F. +3 more
core
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source
Does Price or Income Affect Organic Choice? Analysis of U.S. Fresh Produce Users
This study analyzes consumer purchasing behavior of organic fresh fruits and vegetables using the 2006 Nielsen Homescan panel. An ordered logit model was estimated to quantify the impacts of economic and socio-demographic factors on the probability of a ...
Huang, Chung L. +2 more
core
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
Producer Response to State-Sponsored Marketing Programs: The Case of Jersey Fresh
New Jersey agricultural growers were surveyed to understand their willingness to patronize the Jersey Fresh promotional and quality grading program. Growers’ perceptions of the premium logo and their opinions of the quality grading aspect of the Jersey ...
Italia, John +3 more
core
Molecular Oncology, EarlyView.Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen +9 more
wiley +1 more source
Retailer-Wholesaler Response to State-Sponsored Marketing Programs: The Case of Jersey Fresh
Jersey Fresh retailers and wholesalers feel that the logos are effective in increasing sales. Most feel that the popularity of the logo among the consumers is moderate.
Italia, John +3 more
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Consumer behavior with respect to purchase regularity, satisfaction, origin, and willingness to pay for selected local versus non-Tennessee grown fresh produce is examined.
Brooker, John R. +2 more
core