Results 91 to 100 of about 93,643 (333)

The effects of context processing on social cognition impairments in adults with Aspergers syndrome [PDF]

, 2014
Social cognition—the basis of all communicative and otherwise interpersonal relationships—is embedded in specific contextual circumstances which shape intrinsic meanings.
Báez Buitrago, Sandra Jimena, Ibañez, Agustin Mariano   +1 more
core   +1 more source

Skeletal Muscle Biomarkers of Amyotrophic Lateral Sclerosis: A Large‐Scale, Multi‐Cohort Proteomic Study

Annals of Neurology, EarlyView.
Objective Biomarkers with clear contexts of use are important tools for amyotrophic lateral sclerosis (ALS) therapy development. Understanding their longitudinal trajectory in the untreated state is key to their use as potential markers of pharmacodynamic response.
Oleksandr Dergai, Joanne Wuu, Magdalena Koziczak‐Holbro, Andrea Malaspina, Volkan Granit, Jessica P. Hernandez, Anne Cooley, Ruchika Sachdev, Lili Yu, Michael Bidinosti, Ludivine Flotte, Mark Nash, Lori L. Jennings, James D. Berry, Lucie I. Bruijn, Sophie Brachat, Michael Benatar   +16 more
wiley   +1 more source

Clinicopathological evaluation of chronic traumatic encephalopathy in players of American football [PDF]

, 2017
IMPORTANCE: Players of American football may be at increased risk of long-term neurological conditions, particularly chronic traumatic encephalopathy (CTE).
Abdolmohammadi, Bobak, Alosco, Michael L., Alvarez, Victor E., Baugh, Christine M., Cantu, Robert C., Chaisson, Christine E., Cormier, Kerry A., Daneshvar, Daniel H., Goldstein, Lee E., Huber, Bertrand R., Katz, Douglas I., Kiernan, Patrick T., Kowall, Neil W., Kubilus, Caroline A., Martin, Brett M., McClean, Michael D., McHale, Lisa, McKee, Ann C., Mez, Jesse, Montenigro, Phillip H., Murphy, Lauren, Nowinski, Christopher J., Solomon, Todd M., Stein, Thor D., Stern, Robert A., Tripodis, Yorghos, Weuve, Jennifer   +26 more
core   +1 more source

An Investigation of Hyperostosis Frontalis Interna in a Modern Anatomical Body Donor Population

Clinical Anatomy, EarlyView.
ABSTRACT This research sought to examine the prevalence and severity of hyperostosis frontalis interna (HFI) in the Chicagoland anatomical body donor population. The study further aimed to elucidate potential demographic risk factors for HFI, including sex, age at death, and structural vulnerability index (SVI), as well as any common comorbidities, as ...
Amy C. Beresheim, Amanda Hall
wiley   +1 more source

Frontotemporal dementia

Canadian Medical Association Journal, 2023
Medina-Rioja, Raul, Gonzalez-Calderon, Gina, Masellis, Mario   +2 more
openaire   +2 more sources

Intepirdine Derivatives Possessing Dual 5HT6 Antagonism / HDAC6 Inhibitory Activity

Chemistry – A European Journal, EarlyView.
In the context of developing therapies for dementias and cognitive decline, potent dual acting molecules targeting the GPCR 5HT6 and the enzyme HDAC6 with favorable BBB penetration profile were designed and synthesised. Abstract Alzheimer's Disease (AD) impacts significantly the quality of life of people aged over 65 years old, while millions more ...
Andreas Gkanas, Maria Koutiva, Theodora Katsila, Vivi Bafiti, Minos‐Timotheos Matsoukas, Vasilios Panagiotopoulos, Andrzej J. Bojarski, Theodoros Gkouvitsas, Georgios Moukas, Gerasimos Rassias   +9 more
wiley   +1 more source

Unlocking the Link of Twin Profiles of Plasma Fatty Acids and Genetic Risk and Their Interactions With Incident Dementia

Food Frontiers, EarlyView.
Plasma MUFAs, n‐6 PUFAs (particularly LA), and n‐3 PUFAs (particularly non‐DHA n‐3 PUFAs) were found to be inversely associated with dementia risk. The interactions with APOE genotypes and genetic risk score were also observed, as well as the mediation of serum biomarkers. The study highlights the importance of refining plasma fatty acid profiles based
Hao Ye, Haoyin Liu, Yin Li, Yingyu Huang, Jianxin Yao, Yang Ao, Xiaohui Liu, Xunan Lin, Xiaoran Song, Pan Zhuang, Yu Zhang, Jingjing Jiao   +11 more
wiley   +1 more source

Behavioral variant frontotemporal dementia in patients with previous severe mental illness: a systematic and critical review

Arquivos de Neuro-Psiquiatria
Objectives: To explore the relationship between severe/serious mental illness (SMI) and the behavioral variant of frontotemporal dementia (bvFTD), as the patterns of symptoms and cognitive performance that characterize both disorders share similarities.
Leandro Boson Gambogi, Henrique Cerqueira Guimarães, Leonardo Cruz De Souza, Paulo Caramelli   +3 more
doaj   +1 more source

Agraphia in Bulbar-Onset Amyotrophic Lateral Sclerosis: Not Merely a Consequence of Dementia or Aphasia

Behavioural Neurology, 2008
The clinical significance and characteristics of writing errors in bulbar-onset amyotrophic lateral sclerosis (ALS) are not clear. We retrospectively investigated writing samples in 19 patients with bulbar-onset ALS without preceding extra-motor symptoms.
Hiroo Ichikawa, Nobuyoshi Takahashi, Soutaro Hieda, Hideki Ohno, Mitsuru Kawamura   +4 more
doaj   +1 more source

C9orf72 Repeat Expansion Induces Metabolic Dysfunction in Human iPSC‐Derived Microglia and Modulates Glial‐Neuronal Crosstalk

Glia, EarlyView.
C9orf72 microglia display heightened glycolysis and oxidative stress, driving astrocytic reprogramming that impacts motor neurons. iPSC tricultures uncover key glial–neuronal interactions in C9orf72 pathology. ABSTRACT The C9orf72 hexanucleotide repeat expansion mutation is the most common genetic cause of amyotrophic lateral sclerosis (ALS) and ...
Marika Mearelli, Insa Hirschberg, Christin Weissleder, Carmela Giachino, María José Pérez, Malvina Dubroux, Francesca Provenzano, Mafalda Rizzuti, Linda Ottoboni, Udit Sheth, Tania F. Gendron, Stefania Corti, Michela Deleidi   +12 more
wiley   +1 more source