Results 91 to 100 of about 53,213 (267)

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, EarlyView.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source

Neuropsychiatric symptoms in frontotemporal dementia: a case report

European Psychiatry
Introduction We present the case of a 70-year-old man who, after presenting atypical depressive symptoms, was diagnosed with incipient frontotemporal dementia.
A. Izquierdo De La Puente, P. del Sol Calderón, R. Fernandez Fernandez   +2 more
doaj   +1 more source

Susceptible genes and disease mechanisms identified in frontotemporal dementia and frontotemporal dementia with Amyotrophic Lateral Sclerosis by DNA-methylation and GWAS [PDF]

, 2017
Erdogan Taskesen, Aniket Mishra, Sophie van der Sluis, Raffaele Ferrari, D. G. Hernandez, M. A. Nalls, Jonathan D. Rohrer, Adaikalavan Ramasamy, John B. Kwok, Carol Dobson‐Stone, Peter R. Schofield, Glenda M. Halliday, J. R. Hodges, Olivier Piguet, Lauren Bartley, Emma E. Thompson, Eric Haan, Israel Alejandro Quijano-Hernández, Agustı́n Ruiz, Merçé Boada, Barbara Borroni, Alessandro Padovani, Carlos Cruchaga, Nigel J. Cairns, Luisa Benussi, Giuliano Binetti, Roberta Ghidoni, Gianluigi Forloni, Diego Albani, Daniela Galimberti, Chiara Fenoglio, María Serpente, Elio Scarpini, Jordi Clarimón, Alberto Lleó, Rafael Blesa, María Landqvist Waldö, Kristina Nilsson, Christer Nilsson, I. R. A. Mackenzie, Ging‐Yuek Robin Hsiung, David Mann, Jordan Grafman, Christopher M. Morris, Johannes Attems, Timothy D. Griffiths, Ian G. McKeith, Alan Thomas, Pietro Pietrini, Edward D. Huey, Eric M. Wassermann, Atik Baborie, Evelyn Jaros, Michael Tierney, Pau Pástor, Cristina Razquín, Sara Ortega‐Cubero, Elena Alonso, Robert Perneczky, Janine Diehl‐Schmid, Panagiotis Alexopoulos, Andrea Kurz, Innocenzo Rainero, Elisa Rubino, Lorenzo Pinessi, Ekaterina Rogaeva, Peter St George‐Hyslop, Giacomina Rossi, Fabrizio Tagliavini, Giorgio Giaccone, James B. Rowe, Johannes C. M. Schlachetzki, James Uphill, J. Collinge, Simon Mead, Adrian Danek, Vivianna M. Van Deerlin, Murray Grossman, John Q. Trojanowski, Julie van der Zee, Christine Van Broeckhoven, Stefano F. Cappa, Isabelle Leber, Didier Hannequin, Véronique Golfier, Martine Vercelletto, Alexis Brice, Benedetta Nacmias, Sandro Sorbi, Silvia Bagnoli, Irene Piaceri, Jens Høiriis Nielsen, L. E. Hjermind, Markus J. Riemenschneider, Manuel Mayhaus, Bernd Ibach, Gilles Gasparoni, Sabrina Pichler, Wei Gu, Martin N. Rossor   +99 more
openalex   +1 more source

Multidimensional Apathy in Behavioral Variant Frontotemporal Dementia, Primary Progressive Aphasia, and Alzheimer Disease [PDF]

, 2020
Ratko Radaković, Shuna Colville, Denise Cranley, John M. Starr, Suvankar Pal, Sharon Abrahams   +5 more
openalex   +1 more source

Blood-based protein biomarkers in definite frontotemporal dementia: a case-control study [PDF]

, 2022
Charlotte E. Teunissen, Marta del Campo, Carel F.W. Peeters, Lieke Meeter, Harro Seelaar, Marleen J.A. Koel‐Simmelink, Inez H.G.B. Ramakers, Huub A. M. Middelkoop, Peter Paul De Deyn, Jurgen Claessen, John C. van Swieten, Claire Bridel, Jeroen J.M. Hoozemans, Wiesje M. van der Flier, Philip Scheltens, Yolande A.L. Pijnenburg, Rosha Babapour-Mofrad   +16 more
openalex   +1 more source

Neurofilament light chain as a marker of peripheral nerve damage in vasculitic neuropathy? A cross‐compartmental correlation analysis in patients undergoing nerve biopsy

Brain Pathology, EarlyView.
To assess neurofilament light chain (NfL) as a biomarker of peripheral nerve damage, we correlated serumNfL concentrations with histopathological parameters from matched sural nerve biopsies. SerumNfL levels correlated with markers of acute axonal degeneration, but not with parameters reflecting chronic axonal loss.
Simon Streit, Jenny Meinhardt, Niclas Gimber, John Kestenbach, Christin Siewert, Jan Schmoranzer, Christian Meisel, Klemens Ruprecht, Frank L. Heppner, Péter Körtvélyessy, Werner Stenzel   +10 more
wiley   +1 more source

Neuropathology of frontotemporal lobar degeneration: A review

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD)
Valéria Santoro Bahia, Leonel Tadao Takada, Vincent Deramecourt   +2 more
doaj   +1 more source

An Autopsy Case of Traumatic Brain Injury (TBI) Presenting as Frontotemporal Dementia with Klüver‐Bucy Syndrome [PDF]

, 2001
Osamu Yokota, Seishi Terada, Hideki Ishizu, Hanae Nakashima, Yoshikatsu Fujisawa, Ken Sasaki, Shigetoshi Kuroda   +6 more
openalex   +1 more source

Sialylation patterns in cerebral amyloid angiopathy

Brain Pathology, EarlyView.
This study is the first to localize and evaluate sialylation modifications in the context of Alzheimer's Disease and Cerebral Amyloid Angiopathy, revealing a unique disease‐specific increase in intravascular sialylation. Abstract Glycosylation is the most common form of post‐translational modification in the brain and becomes significantly altered in ...
Caitlyn Fastenau, Rebecca Crisp, Mallory Keating, Elizabeth Ochoa, Timothy E. Richardson, Margaret E. Flanagan, Jamie M. Walker, Sarah C. Hopp, Kevin F. Bieniek   +8 more
wiley   +1 more source

A complex network perspective on brain disease

Biological Reviews, EarlyView.
ABSTRACT If brain anatomy and dynamics have a complex network structure as it has become standard to posit, it is reasonable to assume that such a structure should play a key role not only in brain function but also in brain dysfunction. However, exactly how network structure is implicated in brain damage and whether at least some pathologies can be ...
David Papo, Javier M. Buldú
wiley   +1 more source