Results 91 to 100 of about 364,393 (335)

Mutant Tau knock-in mice display frontotemporal dementia relevant behaviour and histopathology [PDF]

, 2016
Peer ...
Drever, Benjamin D., Koss, David J., Platt, Bettina, Plucinska, Kaja, Riedel, Gernot, Robinson, Lianne, Stoppelkamp, Sandra, Veselcic, Peter   +7 more
core   +2 more sources

GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration

Alzheimer's &Dementia, EarlyView.
Abstract INTRODUCTION We examined how abnormal prefrontal neurophysiology and changes in gamma‐aminobutyric acid‐ergic (GABAergic) neurotransmission contribute to behavioral impairments in disorders associated with frontotemporal lobar degeneration (FTLD). METHODS We recorded magnetoencephalography during an adaptive visuomotor task from 11 people with
Laura E. Hughes, Natalie E. Adams, Matthew A. Rouse, Michelle Naessens, Alexander Shaw, Alexander G. Murley, Thomas E. Cope, Negin Holland, David Nesbitt, Duncan Street, David J. Whiteside, James B. Rowe   +11 more
wiley   +1 more source

Mild behavioral impairment as a potential marker of predementia risk states in motor neuron diseases

European Journal of Neurology, Volume 30, Issue 1, Page 47-56, January 2023., 2023
Abstract Background and purpose Mild behavioral impairment (MBI) has been increasingly regarded as the neurobehavioral axis of predementia risk states, but a specific investigation of its detection as a potential marker of prodromal dementia in motor neuron diseases (MNDs) is still lacking.
Pilar M. Ferraro, Ester Gervino, Emiliano De Maria, Giuseppe Meo, Marta Ponzano, Matteo Pardini, Alessio Signori, Angelo Schenone, Luca Roccatagliata, Claudia Caponnetto   +9 more
wiley   +1 more source

Frontotemporal Dementia: A Clinical Review

Seminars in neurology, 2019
Frontotemporal dementias are a clinically, neuroanatomically, and pathologically diverse group of diseases that collectively constitute an important cause of young-onset dementia.
H. Sivasathiaseelan, C. Marshall, Jennifer L. Agustus, E. Benhamou, R. Bond, Janneke E. P. van Leeuwen, C. Hardy, J. Rohrer, J. Warren   +8 more
semanticscholar   +1 more source

Validating the Accuracy of Parkinson's Disease Clinical Diagnosis: A UK Brain Bank Case–Control Study

Annals of Neurology, EarlyView.
Objective Despite diagnostic criteria refinements, Parkinson's disease (PD) clinical diagnosis still suffers from a not satisfying accuracy, with the post‐mortem examination as the gold standard for diagnosis. Seminal clinicopathological series highlighted that a relevant number of patients alive‐diagnosed with idiopathic PD have an alternative post ...
Lazzaro di Biase, Pasquale Maria Pecoraro, Vincenzo Di Lazzaro   +2 more
wiley   +1 more source

Lower hypothalamic volume with lower body mass index is associated with shorter survival in patients with amyotrophic lateral sclerosis

European Journal of Neurology, Volume 30, Issue 1, Page 57-68, January 2023., 2023
Abstract Background and purpose Weight loss in patients with amyotrophic lateral sclerosis (ALS) is associated with faster disease progression and shorter survival. Decreased hypothalamic volume is proposed to contribute to weight loss due to loss of appetite and/or hypermetabolism.
Jeryn Chang, Thomas B. Shaw, Cory J. Holdom, Pamela A. McCombe, Robert D. Henderson, Jurgen Fripp, Markus Barth, Christine C. Guo, Shyuan T. Ngo, Frederik J. Steyn, For the Alzheimer's Disease Neuroimaging Initiative   +10 more
wiley   +1 more source

Novel CSF biomarkers in genetic frontotemporal dementia identified by proteomics

Annals of Clinical and Translational Neurology, 2019
To identify novel CSF biomarkers in GRN‐associated frontotemporal dementia (FTD) by proteomics using mass spectrometry (MS).
E. L. van der Ende, L. Meeter, C. Stingl, J. V. van Rooij, M. Stoop, D. Nijholt, Raquel Sánchez-Valle, C. Graff, Linn Öijerstedt, M. Grossman, C. Mcmillan, Y. Pijnenburg, R. Laforce, G. Binetti, L. Benussi, R. Ghidoni, T. Luider, H. Seelaar, J. V. van Swieten   +18 more
semanticscholar   +1 more source

Frequency and Early Predictors of Cognitive Deterioration in Amyotrophic Lateral Sclerosis: A Longitudinal Population‐Based Study

Annals of Neurology, EarlyView.
Objective The objective is to evaluate cognitive and behavioral progression and identify early predictors of these changes in a cohort of amyotrophic lateral sclerosis (ALS) patients. Methods A total of 161 ALS patients were tested at diagnosis (T0), and 107 were re‐tested after 1 year (T1) using cognitive/behavioral tests. All patients underwent whole‐
Barbara Iazzolino, Francesca Palumbo, Cristina Moglia, Umberto Manera, Maurizio Grassano, Enrico Matteoni, Sara Cabras, Maura Brunetti, Rosario Vasta, Marco Pagani, Gabriele Mora, Antonio Canosa, Andrea Calvo, Adriano Chiò   +13 more
wiley   +1 more source

C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins [PDF]

, 2014
An expanded GGGGCC repeat in C9orf72 is the most common genetic cause of frontotemporal dementia and amyotrophic lateral sclerosis. A fundamental question is whether toxicity is driven by the repeat RNA itself and/or by dipeptide repeat proteins ...
Cabecinha, M, Clayton, EL, Cleverley, K, Devoy, A, Dols, J, Fisher, EMC, Fratta, P, Grönke, S, Hendrich, O, Isaacs, AM, Mizielinska, S, Moens, T, Niccoli, T, Nicoll, AJ, Norona, FE, Partridge, L, Pickering-Brown, S, Pietrzyk, J, Ridler, CE, Woollacott, IOC   +19 more
core   +1 more source

Brain Metabolic Features of FUS‐ALS: A 2‐[18F]FDG‐PET Study

Annals of Neurology, EarlyView.
Objective We aimed at evaluating the brain metabolic features of fused in sarcoma amyotrophic lateral sclerosis (FUS‐ALS) compared with sporadic ALS (sALS), using 2‐[fluorine‐18] fluoro‐2‐deoxy‐D‐glucose positron emission tomography (2‐[18F]FDG‐PET). Methods We employed the 2‐sample t‐test model of SPM12, implemented in MATLAB, to compare 12 FUS‐ALS ...
Antonio Canosa, Umberto Manera, Rosario Vasta, Grazia Zocco, Francesca Di Pede, Sara Cabras, Filippo De Mattei, Francesca Palumbo, Barbara Iazzolino, Emilio Minerva, Luca Sbaiz, Maura Brunetti, Salvatore Gallone, Maurizio Grassano, Enrico Matteoni, Giulia Polverari, Giuseppe Fuda, Federico Casale, Paolina Salamone, Giovanni De Marco, Giulia Marchese, Cristina Moglia, Andrea Calvo, Marco Pagani, Adriano Chiò   +24 more
wiley   +1 more source