Results 131 to 140 of about 93,643 (333)

Prematurely Aged Human Microglia Exhibit Impaired Stress Response and Defective Nucleocytoplasmic Shuttling of ALS Associated FUS

Aging Cell, EarlyView.
We developed a human microglia aging model by doxycycline‐induced GFP‐progerin expression, which offers a valuable tool to study human microglial aging and its contribution to neurodegeneration. Induced HMC3‐Progerin cells exhibited increased age markers as well as transcriptomic alterations, including an age‐associated transcriptomic shift and ...
Christiane Hartmann, Christina Haß, Muriel Knobloch, Israel Barrantes, Laura Fumagalli, Jessie Premereur, Franz Markert, Maite Peters, Georgia Koromila, Alexander Hartmann, Kathrin Jäger, Jette Abel, Renzo Mancuso, Alexander Storch, Michael Walter, Georg Fuellen, Andreas Hermann   +16 more
wiley   +1 more source

Neuropsychiatric symptoms in frontotemporal dementia: a case report

European Psychiatry
Introduction We present the case of a 70-year-old man who, after presenting atypical depressive symptoms, was diagnosed with incipient frontotemporal dementia.
A. Izquierdo De La Puente, P. del Sol Calderón, R. Fernandez Fernandez   +2 more
doaj   +1 more source

Frontotemporal dementia [PDF]

Continuum, 2007
Indre V. Viskontas, Bruce L. Miller
openaire   +2 more sources

Reply: “PGRN Manifesting as Parkinson's Disease: Counseling and Treatment Implications”

Movement Disorders Clinical Practice, EarlyView.
Angelo Antonini, Giulia Bonato, Miryam Carecchio   +2 more
wiley   +1 more source

A systematic review of interventions for persons living with dementia: The Geriatric ED Guidelines 2.0

Academic Emergency Medicine, EarlyView.
Abstract Background The increasing prevalence of dementia poses significant challenges for emergency department (ED) care, as persons living with dementia (PLWD) more frequently experience adverse outcomes such as delirium, prolonged stays, and higher mortality rates.
Sangil Lee, Michelle Suh, Luna Ragsdale, Justine Seidenfeld, James D. van Oppen, Lauren Lapointe‐Shaw, Carolina Diniz Hooper, James Jaramillo, Annie B. Wescott, Alexander X. Lo, Kaiho Hirata, Maura Kennedy, Lauren Cameron Comasco, Christopher R. Carpenter, Teresita M. Hogan, Shan W. Liu, Geriatric ED Guidelines Dementia Writing Group, Scott Dresden, Angel Li, Cameron J. Gettel, R. Doreen Monks   +20 more
wiley   +1 more source

Neuropathology of frontotemporal lobar degeneration: A review

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD)
Valéria Santoro Bahia, Leonel Tadao Takada, Vincent Deramecourt   +2 more
doaj   +1 more source

Frontotemporal dementia with ubiquitinated inclusions: A case study of the regional distribution of hippocampal pathology [PDF]

, 2000
Bess Mehring, Judy C.Y. Lin, Dahlia Wilson, Carol F. Lippa   +3 more
openalex   +1 more source

Social cognition in amyotrophic lateral sclerosis [PDF]

, 2011
Andersen, Cavallo, Cavallo, Iroi, Meier, Stone, Tsermentseli   +6 more
core   +1 more source

Dendritic location of dystrophic neurites in FTLD‐TDP type C with annexinopathy

Brain Pathology, EarlyView.
The type C variant of FTLD‐TDP (TDP‐C) is defined by long dystrophic neurites that are immunopositive for both phosphorylated TDP and annexin A11 (ANXA11). Kawles et al. are the first paper to systematically show that these neurites are likely of dendritic origin.
Allegra Kawles, Antonia Zouridakis, Caroline Nelson, Rachel Keszycki, Grace Minogue, Alyssa Macomber, Pouya Jamshidi, Rudolph J. Castellani, Changiz Geula, Tamar Gefen, M‐Marsel Mesulam   +10 more
wiley   +1 more source

Dysregulation of the endosomal sorting complex III is linked to neurodegeneration in progressive multiple sclerosis

Brain Pathology, EarlyView.
This study shows that components of the ESCRT‐III membrane repair machinery, VPS4B and CHMP2A, are dysregulated in progressive MS and are associated with higher neurodegeneration and inflammation. This might lead to improper function of the complex to inhibit the final stages of necroptosis activation and thus impede neuronal cell death.
Carmen Picon, Robertas Aleksynas, Marcelina Wojewska, Francesco de Virgiliis, Doron Merkler, Richard Reynolds   +5 more
wiley   +1 more source