Results 141 to 150 of about 98,352 (316)

Neuropsychiatric symptoms in frontotemporal dementia: a case report

European Psychiatry
Introduction We present the case of a 70-year-old man who, after presenting atypical depressive symptoms, was diagnosed with incipient frontotemporal dementia.
A. Izquierdo De La Puente, P. del Sol Calderón, R. Fernandez Fernandez   +2 more
doaj   +1 more source

E3 ligase Praja1 mediates ubiquitination and degradation of microtubule‐associated protein tau

The FEBS Journal, EarlyView.
E3 ligase Praja1, but not its paralogue Praja2, recognizes and ubiquitinates tau protein for proteasomal degradation. This newly identified function of Praja1‐mediated tau degradation suggests its role in protein quality control, which may provide insights into the pathogenesis of tauopathies.
Shiho Aoki, Wataru Onodera, Akihiko Takashima, Kotaro Kawasaki, Kazuki Imadegawa, Hikaru Kurahashi, Mizuho Oishi, Toru Asahi, Yoshiyuki Soeda   +8 more
wiley   +1 more source

Frontotemporal Dementia

Medwave, 2010
Sleegers, Kristel, Van Broeckhoven, Christine   +1 more
  +6 more sources

Neuropathology of frontotemporal lobar degeneration: A review

Dementia & Neuropsychologia
Frontotemporal lobar degeneration (FTLD) is the second most common cause of presenile dementia. Three main clinical variants are widely recognized within the FTLD spectrum: the behavioural variant of frontotemporal dementia (bvFTD), semantic dementia (SD)
Valéria Santoro Bahia, Leonel Tadao Takada, Vincent Deramecourt   +2 more
doaj   +1 more source

Longitudinal Brain Atrophy Rates in Presymptomatic Carriers of Genetic Frontotemporal Dementia [PDF]

, 2022
Jackie M. Poos, Leonie D. M. Grandpierre, Emma L. van der Ende, Jessica Panman, Janne M. Papma, Harro Seelaar, Esther van den Berg, Ronald van ’t Klooster, Esther E. Bron, Rebecca M. E. Steketee, Meike W. Vernooij, Yolande A.L. Pijnenburg, Serge A.R.B. Rombouts, John C. van Swieten, Lize C. Jiskoot   +14 more
openalex   +1 more source

Co‐localization of tau and TDP‐43 after extracellular vesicle delivery to cells

The FEBS Journal, EarlyView.
Extracellular vesicles (EVs) derived from donor cells transfected with EGFP–2N4R‐tau or mCherry‐wtTDP‐43 were taken up by recipient cells, leading to cytosolic co‐localization of tau and TDP‐43. Molecular modeling revealed that tau and TDP‐43 directly interact through hydrogen bonding, suggesting a mechanistic link underlying their co‐pathology ...
Farhang Aliakbari, Kathryn Volkening, Zahra Nayeri, Aysegul Yucel Polat, Neil Donison, Jacqueline Palik, Michael J. Strong   +6 more
wiley   +1 more source

Proteostasis of organelles in aging and disease

The FEBS Journal, EarlyView.
Cells rely on regulated proteostasis mechanisms to keep their internal compartments functioning properly. When these mechanisms fail, damaged proteins accumulate, disrupting organelles, such as the nucleus, mitochondria, endoplasmic reticulum, Golgi, and lysosomes, as well as membraneless organelles, such as stress granules, processing bodies, the ...
Yara Nabawi, Cansu Doğan, Dunja Petrović, Gülce Perçin, Seda Koyuncu, David Vilchez   +5 more
wiley   +1 more source

Clinical profile, atrophy and inheritance patterns of pathogenic MAPT gene mutations in Frontotemporal dementia detected using whole exome sequencing: a single-center first report from India

BMC Neurology
Background/Objectives Frontotemporal Dementia (FTD) is one of the common causes of early-onset degenerative dementia and is a clinically and pathologically heterogeneous group of neurodegenerative disorders.
Subasree Ramakrishnan, Faheem Arshad, B. S. Keerthana, Susan Bosco, Arun Gokul Pon, V. H. Ganaraja, Deekshitha Madhusudhan, R. Mahima, Gautham Arunachal, Karthick Kulanthaivelu, Suvarna Alladi   +10 more
doaj   +1 more source

A Study on False Recognition in Frontotemporal Dementia [PDF]

, 2004
特集1 ...
Hasegawa Chihiro, 長谷川 千洋
core   +1 more source

Development of frontotemporal dementia in a case of bipolar affective disorder: is there a link? [PDF]

, 2011
Andjelka Pavlovic, John Marley, V. Sivakumar   +2 more
openalex   +1 more source