Results 121 to 130 of about 21,388 (227)

Reduced SH3RF3 May Protect Against Alzheimer's Disease by Lowering Microglial Pro‐Inflammatory Responses via Modulation of JNK and NFkB Signaling

Glia, Volume 74, Issue 7, July 2026.
SNPs in SH3RF3 decrease the age of onset of Alzheimer's disease (AD). Reduced SH3RF3 blunts human microglial JNK and NFkB signaling and downstream inflammatory cytokine production, which may partially explain how SH3RF3 SNPs protect against AD. ABSTRACT Understanding how high‐risk individuals are protected from Alzheimer's disease (AD) may illuminate ...
Ronak Patel, Rong Cheng, Christopher L. Cardona, Ellen Angeles, Gunjandeep Singh, Sabrina Miller, Archana Ashok, Andrew F. Teich, Angel Piriz, Aleyda Maldonado, Ivonne Z. Jiménez‐Velázquez, Richard Mayeux, Joseph H. Lee, Andrew A. Sproul   +13 more
wiley   +1 more source

England's Dementia Diagnosis Landscape: Strengths, Limitations, and Future Directions

International Journal of Geriatric Psychiatry, Volume 41, Issue 7, July 2026.
ABSTRACT Background The National Health Service (NHS) England Primary Care Dementia Data (PCDD) provides a comprehensive dementia registry, underpinning national policy to improve diagnosis, care, and support. Methods This paper evaluates the PCDD in comparison with international quality dementia registries (SveDem, NorCog, ADNeT). Results We highlight
Jemma Hazan, Robert Howard, Jeremy D. Isaacs   +2 more
wiley   +1 more source

Phase 1 study of latozinemab in progranulin‐associated frontotemporal dementia

Alzheimer’s & Dementia: Translational Research & Clinical Interventions
INTRODUCTION Heterozygous mutations in the GRN gene lead to reduced progranulin (PGRN) levels in plasma and cerebrospinal fluid (CSF) and are causative of frontotemporal dementia (FTD) with > 90% penetrance.
Michael Ward, Lawrence P. Carter, Julie Y. Huang, Daniel Maslyar, Balasubrahmanyam Budda, Robert Paul, Arnon Rosenthal   +6 more
doaj   +1 more source

CSF placental growth factor – a novel candidate biomarker of frontotemporal dementia

Annals of Clinical and Translational Neurology, 2019
Objective Diagnosis of frontotemporal dementia (FTD) is complicated by the overlap of clinical symptoms with other dementia disorders. Development of robust fluid biomarkers is critical to improve the diagnostic work‐up of FTD. Methods CSF concentrations
Oskar Hansson, Alexander F. Santillo, Lieke H. Meeter, Karin Nilsson, Maria Landqvist Waldö, Christer Nilsson, Kaj Blennow, John C. vanSwieten, Shorena Janelidze   +8 more
doaj   +1 more source

Perceptions of Speech‐Language Pathology Care in Amyotrophic Lateral Sclerosis: A Patient‐Centered Exploratory Study

Muscle &Nerve, Volume 74, Issue 1, Page 216-224, July 2026.
ABSTRACT Introduction/Aims Given limited research on patient perspectives of speech‐language pathology (SLP) services in ALS care, this study aimed to assess the satisfaction with, and understanding of, SLP services by people with ALS (pwALS) and to examine the alignment between services received and patient‐reported impairments.
Jennafer D. Best, Mario A. Landera, Ruixuan Ma, Bridget J. Perry   +3 more
wiley   +1 more source

Distinct behavioural profiles in frontotemporal dementia and semantic dementia

, 2001
Objective - To test predictions that frontotemporal dementia and semantic dementia give rise to distinct patterns of behavioural change. Methods - An informant based semistructured behavioural interview, covering the domains of basic and social emotions,
Blackshaw, A., Snowden, J. S., Bathgate, D., Neary, D., Varma, A., Gibbons, Z. C.   +5 more
core   +1 more source

The SQSTM1 L341V Variant Associated With Sporadic ALS Promotes the Accumulation of Enlarged Ubiquitin‐Positive SQSTM1 Bodies

Genes to Cells, Volume 31, Issue 4, July 2026.
WT SQSTM1 binds to polyubiquitinated cargo and recruits both the cargo and itself to the autophagy‐endolysosomal system (left). In contrast, a fraction of the L341V variant fails to be recruited to autophagosomes and instead forms ubiquitin‐positive large structures (right).
Kento Shimakura, Akira Oka, Haruka Yudahira, Yutaro Hama, Asako Otomo, Shinji Hadano   +5 more
wiley   +1 more source

Frontotemporal dementia and primary progressive aphasia, a review

, 2014
Howard S KirshnerDepartment of Neurology, Vanderbilt University Medical Center, Nashville, TN, USAAbstract: Frontotemporal dementias are neurodegenerative diseases in which symptoms of frontal and/or temporal lobe disease are the first signs of the ...
Kirshner HS
core  

Sporadic Frontotemporal Dementia

Research on the early diagnosis and prognosis of the more common sporadic, non-familial form of FTD is currently insufficient. This causes diagnostic delays and an incomplete understanding of its etiology, hindering the inclusion of sporadic FTD patients in clinical trials.
openaire   +3 more sources

Semantic dementia: a complex and culturally influenced presentation

BJPsych Bulletin
Summary The variants of frontotemporal dementia (FTD) require careful differentiation from primary psychiatric disorders as the neuropsychiatric manifestations can overshadow the unique cognitive deficits.
Richard H. Cole, Camilla N. Clark, Norman A. Poole   +2 more
doaj   +1 more source