Results 131 to 140 of about 21,388 (227)

Neural Organoid Models as a Platform for Studying Disease Mechanisms in Amyotrophic Lateral Sclerosis

Journal of Neurochemistry, Volume 170, Issue 7, July 2026.
Amyotrophic lateral sclerosis (ALS) involves widespread cortical pathology beyond the motor cortex. Human‐induced pluripotent stem cell‐derived neural organoids model cortical tissue in vitro and provide a physiologically relevant platform to study disease mechanisms in ALS.
Kristel N. Eigenhuis, Roberto Montoro Ferrer, R. Jeroen Pasterkamp   +2 more
wiley   +1 more source

Diagnostic accuracy of research criteria for prodromal frontotemporal dementia

: BACKGROUND The Genetic Frontotemporal Initiative Staging Group has proposed clinical criteria for the diagnosis of prodromal frontotemporal dementia (FTD), termed mild cognitive and/or behavioral and/or motor impairment (MCBMI).
Masellis, Mario, Jiskoot, Lize C., Gerhard, Alexander, Bouzigues, Arabella, Convery, Rhian S., Le Ber, Isabelle, Archetti, Silvana, Sogorb-Esteve, Aitana, Galimberti, Daniela, Moreno, Fermin, Sorbi, Sandro, Finger, Elizabeth, Cash, David M., Levin, Johannes, van Swieten, John C, Rowe, James B., Otto, Markus, Benussi, Alberto, Tiraboschi, Pietro, Samra, Kiran, Sanchez-Valle, Raquel, Rohrer, Jonathan D., Gasparotti, Roberto, Grassi, Mario, Vandenberghe, Rik, Graff, Caroline, Todd, Emily G., Gazzina, Stefano, Bocchetta, Martina, Seelaar, Harro, Santana, Isabel, Swift, Imogen, Tartaglia, Maria Carmela, Butler, Chris R., Russell, Lucy L., Laforce, Robert, Synofzik, Matthis, Genetic Frontotemporal Dementia Initiative (GENFI), Ducharme, Simon, Premi, Enrico, Pasquier, Florence, Alberici, Antonella, Padovani, Alessandro, Heller, Carolin, Fumagalli, Giorgio G., Bruffaerts, Rose, Borroni, Barbara, Cantoni, Valentina, Mendon\ue7a, Alexandre   +48 more
core  

NULISA analysis in genetic frontotemporal dementia: a study on the GENetic FTD Initiative

Alzheimer's & Dementia
Abstract Background Given the clinical and pathological heterogeneity of frontotemporal dementia (FTD), there remains a critical need for tools that support the development and implementation of sensitive and specific fluid biomarkers.
Sogorb‐Esteve, Aitana, Gorostiaga‐Belio, Irene, Tucker, Katie, Swann, Owen, Heslegrave, Amanda J, Shoai, Maryam, Zetterberg, Henrik, Rohrer, Jonathan D.   +7 more
openaire   +1 more source

The Cambridge Behavioural Inventory revised

Dementia & Neuropsychologia
Neurobehavioural and psychiatric symptoms are common in a range of neurodegenerative disorders with distinct profiles which are helpful in the diagnosis and monitoring of these disorders.
Helen J. Wear, Catherine J. Wedderburn, Eneida Mioshi, Caroline H. Williams-Gray, Sarah L. Mason, Roger A. Barker, John R. Hodges   +6 more
doaj   +1 more source

Magnetic resonance imaging and histopathology in dementia, clinically of frontotemporal type

, 2000
The magnetic resonance imaging (MRI) and computed tomography findings in 28 patients with the clinical diagnosis of frontotemporal dementia (FTD) were compared with the findings in a control group of 76 individuals without dementia or stroke.
Gustafson, Lars,, Lindgren, Arne,, Larsson, Elna-Marie,, Englund, Elisabet,, Passant, Ulla,, Lund University., Sundgren, Pia, Brun, Arne,   +7 more
core   +1 more source

Clinical and neuropathological associations of plasma Aβ42/Aβ40, p‐tau217 and neurofilament light in sporadic frontotemporal dementia spectrum disorders

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Plasma amyloid beta42/amyloid beta40 (Aβ42/Aβ40) and phosphorylated tau217 (p‐tau217) identify individuals with primary Alzheimer's disease (AD). They may detect AD co‐pathology in the setting of other primary neurodegenerative diseases, but
Binita Rajbanshi, Igor Prufer Q C Araujo, Lawren VandeVrede, Peter A. Ljubenkov, Adam M. Staffaroni, Hilary W. Heuer, Argentina Lario Lago, Eliana Marisa Ramos, Leonard Petrucelli, Tania Gendron, Jeffrey L. Dage, William W. Seeley, Lea T. Grinberg, Salvatore Spina, Randall J. Bateman, Howard J. Rosen, Bradley F. Boeve, Adam L. Boxer, Julio C. Rojas, for the ALLFTD Consortium   +19 more
doaj   +1 more source

Memantine for the treatment of frontotemporal dementia: a meta-analysis

, 2015
Taro Kishi, Shinji Matsunaga, Nakao Iwata Department of Psychiatry, Fujita Health University School of Medicine, Toyoake, Japan Background: There is no conclusive evidence supporting the efficacy of memantine in frontotemporal dementia (FTD).
Iwata N, Matsunaga S, Kishi T
core  

Update on Disease-Modifying Pharmacological Treatments for Frontotemporal Dementia (FTD): A Scoping Review of Registered Trials. [PDF]

NeuroSci
Bartoshyk P, O'Caoimh R.
europepmc   +1 more source

FTD-MND - behavioural variant frontotemporal dementia

, 2021
openaire   +1 more source

Long non-coding RNA profile in genetic symptomatic and presymptomatic frontotemporal dementia : a GENFI study

: BACKGROUND Long non-coding RNAs (lncRNAs) play crucial roles in gene regulation and are implicated in neurodegenerative diseases, including frontotemporal dementia (FTD).
Masellis, Mario, Foster, Phoebe H., Graff, Caroline, Rotondo, Emanuela, Ferry-Bolder, Eve, Ghezzi, Laura, Jiskoot, Lize C., Sacchi, Luca, Gerhard, Alexander, Bouzigues, Arabella, Seelaar, Harro, Santana, Isabel, Butler, Chris R., Tartaglia, Maria Carmela, Arighi, Andrea, Le Ber, Isabelle, Russell, Lucy L., Laforce, Robert, Synofzik, Matthis, Borracci, Vittoria, Galimberti, Daniela, Fenoglio, Chiara, Moreno, Fermin, Ducharme, Simon, Sorbi, Sandro, Finger, Elizabeth, Pintus, Manuela, S\ue1nchez Valle, Raquel, Pasquier, Florence, Levin, Johannes, Rowe, James B., de Mendon\ue7a, Alexandre, Otto, Markus, Arcaro, Marina, Tiraboschi, Pietro, Rohrer, Jonathan D., Bruffaerts, Rose, Carandini, Tiziana, Genetic FTD Initiative GENFI, Borroni, Barbara, van Swieten, John C., Serpente, Maria, Vandenberghe, Rik   +42 more
core