Results 111 to 120 of about 21,388 (227)

Effect of DHX36 knockout on motor control and cognitive function with implications for frontotemporal dementia

, 2023
There are currently 50,000-60,000 Americans suffering from frontotemporal dementia (FTD) and an additional ~5,000 patients diagnosed annually. Median mortality post-diagnosis is 6 +/- 1.1 years (95% CI) and there is no known cure.
Anderson, Quinn T.
core  

The Chemical Regulatory Landscape of Biomolecular Condensates

Aggregate, Volume 7, Issue 7, July 2026.
Chemical regulation of biomolecular phase separation offers a unique opportunity to bridge molecular‐level chemistry with emergent cellular organization. Chemically informed strategies for controlling condensate condensates through chemically tractable parameters such as interaction valency, solvent quality, and molecular crowding provides a unifying ...
Di Liu, Xin Zhang
wiley   +1 more source

MET‐FTD: Music‐based Empathy Training for Frontotemporal Dementia

Alzheimer's & Dementia
Abstract Background Behavioral variant frontotemporal dementia (bvFTD) often presents with social cognition and behavior changes out of proportion to cognitive decline. BvFTD has the highest caregiver burden of any dementia, leading to significant marital problems not infrequently ending in ...
Seibert, Kaitlin, Badillo‐Goicoechea, Elena, Lee, Grace, Breese, Miles, Krings, Mia, Freiman, Rebecca J.F., Wolfe, Jeffrey, Bonakdarpour, Borna   +7 more
openaire   +2 more sources

Kat5 cKO mouse replicates biological domain signatures associated with Alzheimer's disease

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Alzheimer's disease (AD) can be caused by autosomal‐dominant familial Alzheimer's disease (FAD) mutations in amyloid precursor protein (APP) or presenilin‐1 and 2, which form an enzyme substrate complex. KAT5 binds to the APP intracellular domain.
Greg A Cary, Jessica E. Young, Shannon E. Rose, Harald Frankowski, Heather Wilkins, Sai Sruthi Amirtha Ganesh, Julia Draper, Martin Darvas, Mark Bothwell, Suman Jayadev, Aquene N. Reid, Anna Greenwood, Allan I. Levey, Karina Leal, Gregory W. Carter, Jesse C. Wiley   +15 more
wiley   +1 more source

Elimination of tau tangles and soluble aggregates with the small molecule ACI‐16664 prevents neurodegeneration in vivo

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Pathological tau aggregates are key therapeutic targets in Alzheimer's disease (AD), but current approaches face limitations including poor intracellular penetration, lack of selectivity for aggregated over physiological tau, or reliance on invasive administration.
Nicolas Preitner, Véronique Dehlinger, Patrick Rodriguez, Kerstin Fabbri, Yvan Varisco, Matteo Pigni, Alessandra Lovison, Lucas Münzenmaier, Kasia Piorkowska, Aline Fuchs, Nadine Ait‐Bouziad, Nicolas Fournier, Sandra Jepaul, Jérôme Molette, Emanuele Gabellieri, Vincent Darmency, Sonia Poli, Andrea Pfeifer, Marie Kosco‐Vilbois, Francesca Capotosti   +19 more
wiley   +1 more source

Case report: Assessing criminal responsibility and recidivism risk in the behavioral variant of frontotemporal dementia

Frontiers in Psychiatry
Frontotemporal dementia (FTD) affects the frontal and temporal lobes of the brain, leading to personality changes, language impairments, and behavioral disturbances, including impulsivity and disinhibition. Assessing responsibility and recidivism risk in
Anouk Karcher, Rayane Hamza, Camille Jantzi, Camille Jantzi   +3 more
doaj   +1 more source

Acute viral encephalitis impacts dense‐core amyloid plaque pathology and dysregulates myeloid responses to amyloid plaques

Alzheimer's &Dementia, Volume 22, Issue 7, July 2026.
Abstract INTRODUCTION Recent epidemiological datasets have associated viral encephalitis exposure (i.e., viral‐induced neuroinflammation) with increased risk of Alzheimer's disease (AD) and dementia, highlighting the need to uncover how it may impact AD neuropathology.
Dominic Ibarra Javonillo, Susana Furman, Lucas Le, Kellie Fernandez, Jazmyn Mulford, Vidushi Singla, Roshni Jha, Kate Inman Tsourmas, Nellie E. Kwang, Kim N. Green, Thomas E. Lane   +10 more
wiley   +1 more source

Performance of plasma p‐tau217 and NfL in an unselected memory clinic setting

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Plasma phosphorylated tau‐217 (p‐tau217) and neurofilament light (NfL) can differentiate between different dementias in selected cohorts. We aim to test the discrimination potential of these markers in a real‐world cohort.
Rebecca Z. Rousset, Thomas Claessen, Argonde C. vanHarten, Afina W. Lemstra, Yolande A. L. Pijnenburg, Wiesje M. van derFlier, Anouk den Braber, Andreas Jeromin, Inge M. W. Verberk, Charlotte E. Teunissen   +9 more
doaj   +1 more source

Agraphia in Bulbar-Onset Amyotrophic Lateral Sclerosis: Not Merely a Consequence of Dementia or Aphasia

Behavioural Neurology, 2008
The clinical significance and characteristics of writing errors in bulbar-onset amyotrophic lateral sclerosis (ALS) are not clear. We retrospectively investigated writing samples in 19 patients with bulbar-onset ALS without preceding extra-motor symptoms.
Hiroo Ichikawa, Nobuyoshi Takahashi, Soutaro Hieda, Hideki Ohno, Mitsuru Kawamura   +4 more
doaj   +1 more source

Alzheimer's Disease Co‐Pathology and Cognitive Impairment in Amyotrophic Lateral Sclerosis

Annals of Neurology, Volume 100, Issue 1, Page 123-138, July 2026.
Objectives Amyotrophic lateral sclerosis (ALS) and Alzheimer's disease (AD) share neuropathological features, including tau, amyloid, and TDP‐43 pathology. This study investigated whether AD‐related pathological changes are associated with cognitive impairment ALS. Methods Cerebrospinal fluid (CSF total‐tau, phosphorylated‐tau, beta‐amyloid) and plasma
Elisabeth Kasper, Annaliis Lehto, Alexandra Jürs, Nina Nordmann, Oliver Peters, Julian Hellmann, Josef Priller, Eike Jakob Spruth, Gabor C. Petzold, Ina Voigt, Patrick Weydt, Sarah Bernsen, Elisabeth Dinter, Björn Falkenburger, René Günther, Emrah Düzel, Wenzel Glanz, Matthis Synofzik, Lukas Beichert, Annika Spottke, Michael Wagner, Frederic Brosseron, Matthias C. Schmid, Annett Halle, Jochen Herms, Anja Schneider, Stefan Teipel, Johannes Prudlo, Manuela Neumann, Andreas Hermann   +29 more
wiley   +1 more source