Results 71 to 80 of about 10,894 (204)

New functional families (FunFams) in CATH to improve the mapping of conserved functional sites to 3D structures. [PDF]

, 2012
CATH version 3.5 (Class, Architecture, Topology, Homology, available at http://www.cathdb.info/) contains 173 536 domains, 2626 homologous superfamilies and 1313 fold groups.
Cuff, Alison L, Dawson, Natalie L, Dessailly, Benoit H, Furnham, Nicholas, Lee, David, Lees, Jonathan G, Lewis, Tony E, Orengo, Christine A, Rentzsch, Robert, Sillitoe, Ian, Studer, Romain A, Thornton, Janet M, Yeats, Corin   +12 more
core   +1 more source

Archaeal Fructose-1,6-bisphosphate Aldolases Constitute a New Family of Archaeal Type Class I Aldolase [PDF]

Journal of Biological Chemistry, 2001
Fructose-1,6-bisphosphate (FBP) aldolase activity has been detected previously in several Archaea. However, no obvious orthologs of the bacterial and eucaryal Class I and II FBP aldolases have yet been identified in sequenced archaeal genomes. Based on a recently described novel type of bacterial aldolase, we report on the identification and molecular ...
Siebers, B., Tjaden, B., Brinkmann, H., Dorr, C., Lilie, H., van der Oost, J., Verhees, C.H.   +6 more
openaire   +4 more sources

Cell‐Type‐Dependent Metabolic Compensation Preserves Photoreceptor Survival Through Pyruvate Kinase Isoform Balance

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
We investigated the roles of PKM2, PKM1, and LDHA in retinal metabolism and structural integrity. In the normal retina, these enzymes are maintained at defined levels that support photoreceptor function. Rod‐specific deletion of LDHA, alone or with PKM2, caused age‐dependent degeneration, as PKM1 induction did not reach levels comparable to PKM2.
Ammaji Rajala, Larissa J. Trevino, Tyler M. Black, Raju V. S. Rajala   +3 more
wiley   +1 more source

Post‐Translational Regulation of CD8+ T Cell Fate and Dysfunction in Tumor Immunity

Advanced Science, Volume 13, Issue 21, 13 April 2026.
This review delineates how post‐translational modifications (PTMs) function as a central regulatory interface governing CD8+ T cell activation, differentiation, persistence, and exhaustion in antitumor immunity. By integrating antigenic, metabolic, and microenvironmental cues, diverse PTM programs coordinate transcriptional and chromatin states that ...
Zihao Zhou, Xu Chen, Nina Li, Meiyan Zou, Yunfan Lin, Pei Lin, Weiyao Feng, Xinyuan Zhao, Li Cui   +8 more
wiley   +1 more source

Escherichia coli B2 strains prevalent in inflammatory bowel disease patients have distinct metabolic capabilities that enable colonization of intestinal mucosa [PDF]

, 2018
Background Escherichia coli is considered a leading bacterial trigger of inflammatory bowel disease (IBD). E. coli isolates from IBD patients primarily belong to phylogroup B2.
Du, Bin, Fang, Xin, Kavvas, Erol, Mih, Nathan, Monk, Jonathan M., Palsson, Bernhard O., Sastry, Anand V., Seif, Yara, Smarr, Larry   +8 more
core   +5 more sources

Hepatic‐Differentiated Subpopulation in Clear Cell Renal Cell Carcinoma: A Multi‐Omics Analysis of Tumors With Lymphovascular Invasion

Cancer Medicine, Volume 15, Issue 4, April 2026.
A hepatic‐differentiated subpopulation is associated with lymphovascular invasion in clear cell renal cell carcinoma. A visual summary of the key findings from our multi‐omics analysis. The TITANIA framework enabled the identification of a hepatic‐differentiated ccRCC subpopulation characterized by the upregulation of liver‐like metabolic pathways and ...
Shugo Yajima, Yuichiro Tsukada, Riu Yamashita, Takao Fujisawa, Takeshi Kuwata, Reiko Watanabe, Genichiro Ishii, Nina Gabelia, Hartmut Juhl, Yoshikatsu Koga, Takayuki Yoshino, Masaaki Ito, Hitoshi Masuda   +12 more
wiley   +1 more source

Cytosolic Fructose-1,6-bisphosphate Aldolases Modulate Primary Metabolism and Phytohormone Homeostasis in Soybean

Agronomy, 2023
Fructose-1,6-bisphosphate aldolase (FBA) is an important catalytic enzyme in carbon metabolism and plays an important role in plant growth and development. Currently, the biological functions of FBA in soybean (Glycine max) remain unknown. In this study,
Zhimin Qiu, Mengyan Bai, Huaqin Kuang, Xin Wang, Xiaomin Yu, Xiangbin Zhong, Yuefeng Guan   +6 more
doaj   +1 more source

The return of metabolism: biochemistry and physiology of glycolysis

Biological Reviews, Volume 101, Issue 2, Page 751-803, April 2026.
ABSTRACT Glycolysis is a fundamental metabolic pathway central to the bioenergetics and physiology of virtually all living organisms. In this comprehensive review, we explore the intricate biochemical principles and evolutionary origins of glycolytic pathways, from the classical Embden–Meyerhof–Parnas (EMP) pathway in humans to various prokaryotic and ...
Nana‐Maria Grüning, Federica Agostini, Camila Caldana, Johannes Hartl, Matthias Heinemann, Markus A. Keller, Jan Lukas Krüsemann, Costanza Lamperti, Carole L. Linster, Steffen N. Lindner, Julia Muenzner, Jens Nielsen, Zoran Nikoloski, Bettina Siebers, Jacky L. Snoep, Hezi Tenenboim, Bas Teusink, Spencer J. Williams, Mirjam M. C. Wamelink, Markus Ralser   +19 more
wiley   +1 more source

The metabolic significance of octulose phosphates in the photosynthetic carbon reduction cycle in spinach [PDF]

, 2006
14C-Labelled octulose phosphates were formed during photosynthetic14CO2 fixation and were measured in spinach leaves and chloroplasts. Because mono- and bisphosphates of d-glycero- d-ido-octulose are the active 8-carbon ketosugar intermediates of the L ...
John F. Williams, John K. MacLeod, JM Anderson, P Andrews, DI Arnon, KK Arora, KK Arora, RS Bandurski, MRE Bartlett, E Beck, R Begbie, AA Benson, HU Bergmeyer, PA Bleakley, K Brand, M Brin, AJ Charlson, MG Clark, HJ Cluley, LS Daley, IL Flanagan, RT Furbank, J Genovese, M Gibbs, MD Hatch, RL Heath, HW Heldt, HW Heldt, HW Heldt, BL Horecker, BL Horecker, OW Howarth, RG Jensen, WM Kaiser, O Kandler, MK Kapuscinski, NS Karadsheh, GJ Kelly, E Latzko, E Latzko, RMcC Lilley, RMcC Lilley, JK MacLeod, DJ Murphy, G Pettersson, AR Portis, SP Robinson, SP Robinson, H Rosenberg, G Schafer, M Stiller, M Stitt, Y Tashima, CF Sumere Van, LP Vernon, WA Volk, DA Walker, JF Williams, JF Williams, JF Williams, JF Williams, JF Williams, JF Williams, JF Williams, JF Williams, JF Williams, T Wood, IE Woodrow   +67 more
core   +1 more source

Structure of a rabbit muscle fructose-1,6-bisphosphate aldolase A dimer variant [PDF]

Acta Crystallographica Section D Biological Crystallography, 2008
Fructose-1,6-bisphosphate aldolase (aldolase) is an essential enzyme in glycolysis and gluconeogenesis. In addition to this primary function, aldolase is also known to bind to a variety of other proteins, a property that may allow it to perform 'moonlighting' roles in the cell.
Sherawat, Manashi, Tolan, Dean R., Allen, Karen N.   +2 more
openaire   +3 more sources