Results 61 to 70 of about 30,141 (201)

Difference of slope analysis between FTD-GRN+ and FTD-GRN- patients.

open access: yes, 2013
(A) reduced EN connectivity in the left middle frontal gyrus in FTD-GRN- patients, as compared to FTD-GRN+; (B) reduced ventral SN connectivity in the left medial frontal gyrus in GRN+ patients, as compared to FTD-GRN -; (C) reduced dorsal SN ...
Carlo Caltagirone (110756)   +11 more
core   +1 more source

Association of RAS mutational status with clinical outcomes in metastatic colorectal cancer treated with trifluridine/tipiracil or regorafenib

open access: yesScientific Reports
Previous studies demonstrated codon-specific KRAS mutation as a potential biomarker of resistance in metastatic colorectal cancer (mCRC). Our study aimed to evaluate the association of RAS status on survival in patients with mCRC treated with ...
Meng-Che Hsieh   +6 more
doaj   +1 more source

Neurobiological substrates of the positive formal thought disorder in schizophrenia revealed by seed connectome-based predictive modeling

open access: yesNeuroImage: Clinical, 2021
Formal thought disorder (FTD) is a core symptom cluster of schizophrenia, but its neurobiological substrates remain poorly understood. Here we collected resting-state fMRI data from 276 subjects at seven sites and employed machine-learning to investigate
Ji Chen   +13 more
doaj   +1 more source

Autonomic dysfunction and hypothalamic atrophy in frontotemporal dementia and primary psychiatric disorders

open access: yesAlzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
INTRODUCTION Evidence suggests that autonomic symptoms in frontotemporal dementia (FTD) may relate to hypothalamic pathology. We investigated (1) autonomic symptoms in FTD, primary psychiatric disorders (PPD), and controls; (2) hypothalamic volumes; and (
Yannick S. S. Timar   +14 more
doaj   +1 more source

Demographic information of FTD patient groups.

open access: yes, 2013
bvFTD = behavioural variant FTD; CBS = corticobasal syndrome; D = death; F = female; FTD-ALS = FTD with amyotrophic lateral sclerosis; FTDP = FTD with parkinsonism; FTDm = FTD with mixed phenotype; FTDuns = FTD otherwise unspecified; M = male; PNFA ...
Cristina Razquin (379794)   +17 more
core   +1 more source

Ageing as a risk factor for ALS/FTD [PDF]

open access: yesHuman Molecular Genetics, 2017
Like many other neurodegenerative diseases, age is a major risk factor in the development of ALS/FTD. But why is this the case? Recent genetic advances have highlighted some of pathways involved in the development of disease, and, strikingly, they appear to substantially overlap with those known to directly modulate the ageing process.
Teresa Niccoli   +2 more
openaire   +4 more sources

Loss of brainstem white matter predicts onset and motor neuron symptoms in C9orf72 expansion carriers: a GENFI study [PDF]

open access: yes, 2022
BACKGROUND AND OBJECTIVES: The C9orf72 expansion is the most common genetic cause of frontotemporal dementia (FTD) and/or motor neuron disease (MND). Corticospinal degeneration has been described in post-mortem neuropathological studies in these patients,
Masellis, Mario   +178 more
core  

Hyperconnectivity in dementia is early and focal and wanes with progression

open access: yes, 2021
We investigated in a longitudinal multicenter cohort study functional cortical connectivity changes along the course of frontotemporal dementia (FTD) and Alzheimer's disease (AD) from the prodromal stage of the diseases.
Borroni B.   +17 more
core   +1 more source

Real-World Comparison of Trifluridine–Tipiracil with or Without Bevacizumab in Patients with Refractory Metastatic Colorectal Cancer

open access: yesBiomedicines
Background/Objectives: Patients with metastatic colorectal cancer (mCRC) who are refractory to standard chemotherapy face limited treatment options.
Hyunho Kim   +8 more
doaj   +1 more source

Characteristics and progression of patients with frontotemporal dementia in a regional memory clinic network

open access: yesAlzheimer’s Research & Therapy, 2021
Background Due to heterogeneous clinical presentation, difficult differential diagnosis with Alzheimer’s disease (AD) and psychiatric disorders, and evolving clinical criteria, the epidemiology and natural history of frontotemporal lobar degeneration ...
Mélanie Leroy   +16 more
doaj   +1 more source

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