Results 71 to 80 of about 30,141 (201)

Genetic screening in sporadic ALS and FTD [PDF]

Journal of Neurology, Neurosurgery & Psychiatry, 2017
The increasing complexity of the genetic landscape in amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) presents a significant resource and physician training challenge. At least 10% of those diagnosed with ALS or FTD are known to carry an autosomal dominant genetic mutation.
Turner, Martin R, Al-Chalabi, Ammar, Chio, Adriano, Hardiman, Orla, Kiernan, Matthew C, Rohrer, Jonathan D, Rowe, James, Seeley, William, Talbot, Kevin   +8 more
openaire   +9 more sources

An MRI-based strategy for differentiation of frontotemporal dementia and Alzheimer’s disease

Alzheimer’s Research & Therapy, 2021
Background The differential diagnosis of frontotemporal dementia (FTD) and Alzheimer’s disease (AD) is difficult due to the overlaps of clinical symptoms.
Qun Yu, Yingren Mai, Yuting Ruan, Yishan Luo, Lei Zhao, Wenli Fang, Zhiyu Cao, Yi Li, Wang Liao, Songhua Xiao, Vincent C. T. Mok, Lin Shi, Jun Liu, the National Alzheimer’s Coordinating Center, the Alzheimer’s Disease Neuroimaging Initiative, the Frontotemporal Lobar Degeneration Neuroimaging Initiative   +14 more
doaj   +1 more source

Structural and functional brain abnormalities place phenocopy frontotemporal dementia (FTD) in the FTD spectrum

NeuroImage: Clinical, 2016
'Phenocopy' frontotemporal dementia (phFTD) patients may clinically mimic the behavioral variant of FTD (bvFTD), but do not show functional decline or abnormalities upon visual inspection of routine neuroimaging. We aimed to identify abnormalities in gray matter (GM) volume and perfusion in phFTD and to assess whether phFTD belongs to the FTD spectrum.
Steketee, Rebecca, Meijboom, Rozanna, Bron, Esther, Osse, R.J., Koning, I, Jiskoot, Lize, Klein, Stefan, de Jong, Frank jan, van der Lugt, Aad, van Swieten, J.C., Smits, Marion   +10 more
openaire   +3 more sources

Age at diagnosis in FTD.

, 2014
(A) Age at diagnosis in FTD cases registered in SveDem 2008–2011. (B) The proportion of FTD cases in each age group in the total FTD cohort (blue bars), compared to those cases diagnosed in specialist centres where investigations included cognitive ...
Karin Nilsson (281963), Maria Landqvist Waldö (434639), Christer Nilsson (139506), Susanna Vestberg (550317), Alexander Santillo (550316)   +4 more
core   +1 more source

CSF placental growth factor – a novel candidate biomarker of frontotemporal dementia

Annals of Clinical and Translational Neurology, 2019
Objective Diagnosis of frontotemporal dementia (FTD) is complicated by the overlap of clinical symptoms with other dementia disorders. Development of robust fluid biomarkers is critical to improve the diagnostic work‐up of FTD. Methods CSF concentrations
Oskar Hansson, Alexander F. Santillo, Lieke H. Meeter, Karin Nilsson, Maria Landqvist Waldö, Christer Nilsson, Kaj Blennow, John C. vanSwieten, Shorena Janelidze   +8 more
doaj   +1 more source

Restoration of Progranulin Expression Rescues Cortical Neuron Generation in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia

Stem Cell Reports, 2015
Summary: To understand how haploinsufficiency of progranulin (PGRN) causes frontotemporal dementia (FTD), we created induced pluripotent stem cells (iPSCs) from patients carrying the GRNIVS1+5G > C mutation (FTD-iPSCs).
Susanna Raitano, Laura Ordovàs, Louis De Muynck, Wenting Guo, Ira Espuny-Camacho, Martine Geraerts, Satish Khurana, Kim Vanuytsel, Balazs I. Tóth, Thomas Voets, Rik Vandenberghe, Toni Cathomen, Ludo Van Den Bosch, Pierre Vanderhaeghen, Philip Van Damme, Catherine M. Verfaillie   +15 more
doaj   +1 more source

CSF Biomarkers of Neurodegeneration in Progressive Non-fluent Aphasia and Other Forms of Frontotemporal Dementia: Clues for Pathomechanisms?

Frontiers in Neurology, 2018
Frontotemporal Dementia (FTD) encompasses distinct pathophysiologically heterogenous disorders with different genetic and cellular disease mechanisms. The objective of this study is to compare the constellation of biomarkers of neurodegeneration in the ...
Peter Körtvelyessy, Peter Körtvelyessy, Hans J. Heinze, Hans J. Heinze, Hans J. Heinze, Johannes Prudlo, Johannes Prudlo, Daniel Bittner, Daniel Bittner   +8 more
doaj   +1 more source

Accuracies (%) obtained using HV, TBM, and VBM for comparisons C vs. FTD, AD vs. FTD, SMCI vs. FTD, C vs. AD, C vs. PMCI.

, 2013
Accuracies (%) obtained using HV, TBM, and VBM for comparisons C vs. FTD, AD vs. FTD, SMCI vs. FTD, C vs. AD, C vs. PMCI.
Miia Kivipelto (293118), Yawu Liu (284161), Miguel Ángel Muñoz-Ruiz (293116), Päivi Hartikainen (293117), Juha Koikkalainen (201083), Robin Wolz (201080), Eini Niskanen (201087), Sanna-Kaisa Herukka (120810), Jyrki Lötjönen (201097), Daniel Rueckert (171282), Ritva Vanninen (293119), Valtteri Julkunen (201082), Hilkka Soininen (120808)   +12 more
core   +1 more source

A Genome-Wide Screening and SNPs-to-Genes Approach to Identify Novel Genetic Risk Factors Associated with Frontotemporal Dementia [PDF]

, 2015
Frontotemporal dementia (FTD) is the second most prevalent form of early onset dementia after Alzheimer’s disease (AD). We performed a case-control association study in an Italian FTD cohort (n = 530) followed by the novel SNPs-to-genes approach and ...
Maletta, Raffaele G, S. Bagnoli, Piaceri, I, Bagnoli, Silvia, Cusi, Daniele, Singleton, A, Giaccone, G, Archetti, Silvana, Hardy, J, Binetti, Giuliano, Galimberti, Daniela, Manunta, P, G. Milan, F. Tagliavini, Rubino, E, E. Scarpini, A. Singleton, L. Pinessi, Tagliavini, Fabrizio, Bernardi, Livia, Maletta, Raffaele G., F. D'Avila, Milan, G, Barlassina, C, Benussi, L, Novelli, V, Grassi, Mario, Serpente, M, G. Giaccone, PUCA, Annibale Alessandro, Maletta, RG, Borroni, B, Bruni, Amalia C, Palluzzi, Fernando, B. Borroni, V. Novelli, R. Ghidoni, D. Pepe, Ferrari, Raffaele, Archetti, S, R. Ferrari, Bagnoli, S, Rainero, Innocenzo, Manunta, Paolo, Milan, Graziella, Pinessi, Lorenzo, Piaceri, Irene, Scarpini, Elio, I. Piaceri, Pinessi, L, A. Postiglione, Giaccone, Giorgio, M. Franceschi, Momeni, Parastoo, Galimberti, D, D'Avila, F, Novelli, Valeria, S. Archetti, Ghidoni, Roberta, Franceschi, M, Franceschi, Massimo, D’Avila, F, Serpente, Maria, B. Nacmias, Scarpini, E, M. Grassi, Cusi, D, Padovani, A, F. Palluzzi, M. Serpente, Postiglione, A, Ghidoni, R, R. G. Maletta, Hardy, John, A. C. Bruni, A. A. Puca, E. Rubino, L. Benussi, Postiglione, Alfredo, Glorioso, Nicola, Benussi, Luisa, Rossi, Giacomina, Puca, Annibale A., L. Bernardi, Bruni, AC, Puca, AA, Singleton, Andrew, I. Rainero, Palluzzi, F, Binetti, G, D. Galimberti, Bernardi, L, P. Momeni, PADOVANI, Alessandro, Glorioso, N, Nacmias, Benedetta, N. Glorioso, P. Manunta, A. Padovani, G. Rossi, D. Cusi, Bruni, Amalia C., Grassi, M, Rubino, Elisa, Salvi, Erika, Barlassina, Cristina, Tagliavini, F, Pepe, D, G. Binetti, J. Hardy, C. Barlassina, Pepe, Daniele, Momeni, P., Momeni, P, E. Salvi, Rossi, G, Nacmias, B, BORRONI, Barbara, D'Avila, Francesca, Rainero, I, Salvi, E, Ferrari, R   +121 more
core   +1 more source

Motor Neuron Susceptibility in ALS/FTD

Frontiers in Neuroscience, 2019
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the death of both upper and lower motor neurons (MNs) in the brain, brainstem and spinal cord. The neurodegenerative mechanisms leading to MN loss in ALS are not fully understood.
Audrey M. G. Ragagnin, Sina Shadfar, Marta Vidal, Md Shafi Jamali, Julie D. Atkin, Julie D. Atkin   +5 more
openaire   +3 more sources