Results 11 to 20 of about 63,826 (347)

Expanded Proteomic Survey of the Human Parasite Leishmania major Focusing on Changes in Null Mutants of the Golgi GDP-Mannose/Fucose/Arabinopyranose Transporter LPG2 and of the Mitochondrial Fucosyltransferase FUT1

open access: yesMicrobiology Spectrum, 2022
The trypanosomatid protozoan parasite Leishmania has a significant impact on human health globally. Understanding the pathways associated with virulence within this significant pathogen is critical for identifying novel vaccination and chemotherapy ...
Gloria Polanco   +3 more
doaj   +1 more source

Fucose promotes intestinal stem cell-mediated intestinal epithelial development through promoting Akkermansia-related propanoate metabolism

open access: yesGut Microbes, 2023
Intestinal stem cells (ISCs) are critical for the development and rapid turnover of intestinal epithelium. The regulatory effects of gut microbiota and their metabolites on ISCs stemness remain elusive.
Caihan Duan   +7 more
doaj   +1 more source

Effects of L-fucose supplementation on the viability of cancer cell lines

open access: yesMakara Journal of Health Research, 2020
Background: Fucose is a deoxyhexose sugar. While the biological roles of L-fucose remain unclear, the sugar is known to accelerate the malignant potential of cancer cells.
Muhammad Alif Mazlan   +2 more
doaj   +1 more source

Developing a Fluorescent Inducible System for Free Fucose Quantification in Escherichia coli

open access: yesBiosensors, 2023
L-Fucose is a monosaccharide abundant in mammalian glycoconjugates. In humans, fucose can be found in human milk oligosaccharides (HMOs), mucins, and glycoproteins in the intestinal epithelium.
Samantha Nuñez   +2 more
doaj   +1 more source

Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

open access: yesJournal of Biological Chemistry, 2022
Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known to cause leukocyte adhesion deficiency II. However, improvement of fucosylation in leukocyte adhesion deficiency II patients treated with exogenous fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which remains a mystery.
Edyta Skurska   +6 more
openaire   +2 more sources

Ratio of salivary sialic acid to fucose as tumor markers in potentially malignant disorders and oral cancer

open access: yesContemporary Clinical Dentistry, 2020
Background: Lack of noninvasive and economically feasible laboratory investigations in the early detection of cancer is a set-back in the prognosis of oral cancer (OC) patients.
Anandhi Sekar Arthisri   +3 more
doaj   +1 more source

Pathogenic Variants in Fucokinase Cause a Congenital Disorder of Glycosylation [PDF]

open access: yes, 2018
FUK encodes fucokinase, the only enzyme capable of converting L-fucose to fucose-1-phosphate, which will ultimately be used for synthesizing GDP-fucose, the donor substrate for all fucosyltransferases.
Bearden, David R.   +9 more
core   +1 more source

The role of the mobile proton in fucose migration [PDF]

open access: yes, 2019
Fucose migration reactions represent a substantial challenge in the analysis of fucosylated glycan structures by mass spectrometry. In addition to the well-established observation of transposed fucose residues in glycan-dissociation product ions, recent ...
Helden, Gert von   +7 more
core   +1 more source

Metabolomic and Transcriptomic Analyses of Escherichia coli for Efficient Fermentation of L-Fucose

open access: yesMarine Drugs, 2019
L-Fucose, one of the major monomeric sugars in brown algae, possesses high potential for use in the large-scale production of bio-based products. Although fucose catabolic pathways have been enzymatically evaluated, the effects of fucose as a carbon ...
Jungyeon Kim   +3 more
doaj   +1 more source

Assessment of serum fucose level among oral squamous cell carcinoma patients: A case-control study

open access: yesJournal of Pharmacy and Bioallied Sciences, 2023
Background: Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the ...
Albert Ashem   +5 more
doaj   +1 more source

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