Results 31 to 40 of about 41,130 (245)

The Threonine That Carries Fucose, but Not Fucose, Is Required for Cripto to Facilitate Nodal Signaling [PDF]

Journal of Biological Chemistry, 2007
Cripto is a membrane-bound co-receptor for Nodal, a member of the transforming growth factor-beta superfamily. Mouse embryos lacking either Cripto or Nodal have the same lethal phenotype at embryonic day 7.5. Previous studies suggest that O-fucosylation of the epidermal growth factor-like (EGF) repeat in Cripto is essential for the facilitation of ...
Shaolin, Shi, Changhui, Ge, Yi, Luo, Xinghua, Hou, Robert S, Haltiwanger, Pamela, Stanley   +5 more
openaire   +2 more sources

The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells.

PLoS ONE, 2018
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley, Shengchen Lin, Daniel K Lester, Eric K Lau, Shengyu Yang   +4 more
doaj   +1 more source

Fucose-Galactose Polymers Inhibit Cholera Toxin Binding to Fucosylated Structures and Galactose-Dependent Intoxication of Human Enteroids

, 2020
A promising strategy to limit cholera severity involves blockers mimicking the canonical cholera toxin ligand (CT) ganglioside GM1. However, to date the efficacies of most of these blockers have been evaluated in noncellular systems that lack ligands ...
Jakob Cervin (4846912), Per Björklund, Gyusaang Youn, Nicole S. Sampson (495978), Andrew Boucher, Lynda Mottram (8564133), Jakob Cervin, Per Björklund (4875400), Ville Wallenius (116662), Lynda Mottram, Nicole S. Sampson, Ville Wallenius, Ulf Yrlid, Andrew Boucher (8564130), Gyusaang Youn (4875403), Ulf Yrlid (698408)   +15 more
core   +1 more source

Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro

Marine Drugs, 2011
Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells.
Anne S. Meyer, Jørn D. Mikkelsen, Marcel Tutor Ale, Hidekazu Tamauchi, Hiroko Maruyama   +4 more
doaj   +1 more source

Fucose as a potential therapeutic molecule against the immune-mediated inflammation in IgA nepharopathy: An unrevealed link

Frontiers in Immunology, 2022
BackgroundIgA nephropathy (IgAN) is an autoimmune disease that affects people of any age and is an important cause of end-stage renal disease. However, the pathogenesis and pathophysiology of IgAN is not clear.
Jianbo Qing, Jianbo Qing, Xueli Hu, Changqun Li, Wenzhu Song, Hasna Tirichen, Hasnaa Yaigoub, Yafeng Li, Yafeng Li, Yafeng Li, Yafeng Li   +10 more
doaj   +1 more source

In Silico and In Vitro Investigation of the Distribution and Expression of Key Genes in the Fucose Operon of Escherichia coli

Microorganisms, 2023
Many gut bacteria degrade polysaccharides, providing nutritional advantages to their hosts. Fucose, a mucin degradation product, was suggested as a communication molecule between the resident microbiota and external pathogens.
Nehal A. Saif, Yomna A. Hashem, Heba M. Amin, Ramy K. Aziz   +3 more
doaj   +1 more source

Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts

Molecules, 2022
Fucosidases are associated with several pathological conditions and play an important role in the health of the human gut. For example, fucosidases have been shown to be indicators and/or involved in hepatocellular carcinoma, breast cancer, and ...
Yvette M. C. A. Luijkx, Anniek J. Henselijn, Gerlof P. Bosman, Dario A. T. Cramer, Koen C. A. P. Giesbers, Esther M. van ‘t Veld, Geert-Jan Boons, Albert J. R. Heck, Karli R. Reiding, Karin Strijbis, Tom Wennekes   +10 more
doaj   +1 more source

Biological functions of fucose in mammals [PDF]

Glycobiology, 2017
Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by 13 fucosyltransferases, all of which utilize the nucleotide-charged form, GDP-fucose, to modify targets. Three of the fucosyltransferases, FUT8, FUT12/POFUT1 and FUT13/POFUT2,
Michael, Schneider, Esam, Al-Shareffi, Robert S, Haltiwanger   +2 more
openaire   +2 more sources

Correlation of serum levo-fucose levels as a biomarker with tumor node metastasis staging in oral cancer patients

Journal of Pharmacy and Bioallied Sciences, 2016
Background: oral cancer is a result of disordered cellular behavior initiated by various stimuli which is characterized by the alteration of serum glycoproteins consisting of different monosaccharides.
P Redwin Dhas Manchil, E Tatu Joy, M Shashi Kiran, J Eugenia Sherubin, M Farakath Khan, B S Aravind   +5 more
doaj   +1 more source

Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

Journal of Biological Chemistry, 2022
Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known to cause leukocyte adhesion deficiency II. However, improvement of fucosylation in leukocyte adhesion deficiency II patients treated with exogenous fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which remains a mystery.
Edyta Skurska, Bożena Szulc, Dorota Maszczak-Seneczko, Maciej Wiktor, Wojciech Wiertelak, Aleksandra Makowiecka, Mariusz Olczak   +6 more
openaire   +2 more sources