Results 41 to 50 of about 60,769 (251)
, 2022 Fucose is a ubiquitous monosaccharide linked to the core of major classes of glycans and the identification of fucose location is one critical bottleneck in glycomics. This is due to the remarkable inclination of the fucosyl residue to migrate to neighboring throughout mass spectrometric analysis.
Baptiste Moge +3 more
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Biological functions of fucose in mammals [PDF]
Glycobiology, 2017 Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by 13 fucosyltransferases, all of which utilize the nucleotide-charged form, GDP-fucose, to modify targets. Three of the fucosyltransferases, FUT8, FUT12/POFUT1 and FUT13/POFUT2,
Michael, Schneider +2 more
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Targeting anticancer drug delivery to pancreatic cancer cells using a fucose-bound nanoparticle approach. [PDF]
PLoS ONE, 2012 Owing to its aggressiveness and the lack of effective therapies, pancreatic ductal adenocarcinoma has a dismal prognosis. New strategies to improve treatment and survival are therefore urgently required.
Makoto Yoshida +13 more
doaj +1 more source
Helicobacter suis infection alters glycosylation and decreases the pathogen growth inhibiting effect and binding avidity of gastric mucins [PDF]
, 2019 Helicobacter suis is the most prevalent non-Helicobacter pylori Helicobacter species in the human stomach and is associated with chronic gastritis, peptic ulcer disease, and gastric mucosa-associated lymphoid tissue (MALT) lymphoma. H. suis colonizes the
Adamczyk, Barbara +11 more
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Frontiers in Cellular and Infection Microbiology, 2023 IntroductionInfection with strongly β-hemolytic strains of Brachyspira hyodysenteriae leads to swine dysentery (SD), a production-limiting disease that causes mucohemorrhagic diarrhea and typhlocolitis in pigs.
Susanne Je-Han Lin +3 more
doaj +1 more source
Alternating High‐Fat and Polysaccharide Diets Modulates Gut Phage‐Bacterial Interplay
Advanced Science, EarlyView.This study reveals how alternating high‐fat and polysaccharide diets reshape the human gut virome and enhance phage‐bacteria interactions. Using large‐scale metagenomic meta‐analysis and a time‐resolved mouse model, the authors show that diets strongly modulate phage abundance, lifestyle, and gene exchange, offering new insights into nutrition‐guided ...
Fengxiang Zhao +6 more
wiley +1 more source
Exploring the diverse biological significance and roles of fucosylated oligosaccharides
Frontiers in Molecular BiosciencesLong since, carbohydrates were thought to be used just as an energy source and structural material. However, in recent years, with the emergence of the field of glycobiology and advances in glycomics, much has been learned about the biological role of ...
Burcu Pekdemir, Sercan Karav
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Synthesis of Fucose Derivatives with Thiol Motifs towards Suicide Inhibition of Helicobacter pylori
Molecules, 2020 The syntheses of six thiol-exhibiting monosaccharides towards suicide inhibition of Helicobacter pylori are reported. Blood group Antigen Binding Adhesin (BabA), a bacterial membrane-bound lectin, binds to human ABO and Lewis b blood group structures ...
Mark Reihill +3 more
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Fucoidan Is Not Completely Dependent on Degradation to Fucose to Relieve Ulcerative Colitis
Pharmaceuticals, 2022 Recently, fucoidan has been proposed for use as a potential anti-inflammatory drug. The purpose of this study was to investigate the mechanism of fucoidan in the treatment of ulcerative colitis.
Qiang Wei +8 more
doaj +1 more source
Possible role for cell-surface carbohydrate-binding molecules in lymphocyte recirculation. [PDF]
, 1983 We are investigating the hypothesis that carbohydrate-binding molecules on the cell surface are involved in the recirculation of lymphocytes from the bloodstream into lymphoid organs.
Rosen, SD, Stoolman, LM
core +1 more source