Results 41 to 50 of about 41,130 (245)

Activated p53 with Histone Deacetylase Inhibitor Enhances L-Fucose-Mediated Drug Delivery through Induction of Fucosyltransferase 8 Expression in Hepatocellular Carcinoma Cells. [PDF]

, 2016
The prognosis of advanced hepatocellular carcinoma (HCC) is dismal, underscoring the need for novel effective treatments. The α1,6-fucosyltransferase (fucosyltransferase 8, FUT8) has been reported to accelerate malignant potential in HCC. Our study aimed
Junji Kato, Yusuke Kamihara (3214998), Naotaka Hayasaka (3560810), Masayoshi Kobune, Hajime Nakamura, Kohichi Takada, Masayoshi Kobune (151774), Kohichi Takada (151767), Shohei Kikuchi (832677), Yusuke Kamihara, Koji Miyanishi, Hajime Nakamura (3428984), Makoto Usami (757009), Koji Miyanishi (151762), Kazuyuki Murase (151747), Shohei Kikuchi, Takahiro Osuga, Yohei Arihara, Yutaka Okagawa (3560807), Naotaka Hayasaka, Junji Kato (151778), Kazuyuki Murase, Takahiro Osuga (151758), Yutaka Okagawa, Makoto Usami, Yohei Arihara (3560813)   +25 more
core   +1 more source

Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats

Pharmaceutical Biology, 2017
Context: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases.
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari   +2 more
doaj   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources

Assessment of serum fucose level among oral squamous cell carcinoma patients: A case-control study

Journal of Pharmacy and Bioallied Sciences, 2023
Background: Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the ...
Albert Ashem, Dhaval N Mehta, Deepak N Singh, Khwairakpam C Singh, Ch Anupriya, Ahanthem N Devi   +5 more
doaj   +1 more source

Fucose, placental evolution and the glycocode [PDF]

Glycobiology, 2011
A family of 13 fucosyltransferase genes has evolved to catalyze the addition of fucose in various linkage positions to nascent glycoproteins. Null mutations in mice are unearthing unsuspected functions for glycoprotein fucosylation that affect embryo implantation and growth of the conceptus.
Aplin, JD; id_orcid 0000-0001-8777-9261, Jones, CJ   +1 more
openaire   +4 more sources

l-Fucose Synthesis Using a Halo- and Thermophilic l-Fucose Isomerase from Polyextremophilic Halothermothrix orenii

, 2022
l-Fucose isomerase (l-FucI)-mediated isomerization is a promising biotechnological approach for synthesizing various rare sugars of industrial significance, including l-fucose.
Kyoung Kim, In Kim
core   +1 more source

Modulation of Morphology and Glycan Composition of Mucins in Farmed Guinea Fowl (Numida meleagris) Intestine by the Multi-Strain Probiotic Slab51^®

Animals, 2021
Probiotics have become highly recognized as supplements for poultry.Since gut health can be considered synonymous withanimal health, the effects of probiotic Slab51® on the morphology and the glycan composition of guineafowlintestine were examined.
Salvatore Desantis, Livio Galosi, Nicoletta Santamaria, Alessandra Roncarati, Lucia Biagini, Giacomo Rossi   +5 more
doaj   +1 more source

Fucose Sensing Regulates Bacterial Intestinal Colonization [PDF]

, 2014
The mammalian gastrointestinal (GI) tract provides a complex and competitive environment for the microbiota1. Successful colonization by pathogens depends on scavenging nutrients, sensing chemical signals, competing with the resident bacteria, and ...
Pacheco, Alline R., Curtis, Meredith M., Waldor, Matthew, Ritchie, Jennifer M., Moreira, Cristiano G., Sperandio, Vanessa, Munera, Diana   +6 more
core   +1 more source

Up regulation of serum L fucose glycoprotein as a diagnostic biomarker for dysplasia in oral sub mucous fibrosis patients

Heliyon
Glycoproteins, essential for cellular functions, contain monosaccharides like Levo-fucose, crucial for cell communication. Recent research highlights serum L-fucose as a potential biomarker for early detection of malignancies.
Sunil Kumar Vaddamanu, Ravinder S. Saini, Bhavana T. Veerabasavaiah, Fahad Hussain Alhamoudi, AbdulKhaliq Ali F Alshadidi, Antonino Lo Giudice, Marco Cicciù, Giuseppe Minervini   +7 more
doaj   +1 more source

Six fucose-α(1-2) sugars and α-fucose assigned in the human brain using in vivo two-dimensional MRS

, 2014
A growing body of literature has indicated that fucose-α(1–2)-galactose sugars are implicated in the molecular mechanisms that underlie neuronal development, learning and memory in the human brain.
Scott Quadrelli, Ramadan, Saadallah, Mountford, Carolyn, Carolyn Mountford, Lin, Alexander, Alexander Lin, Quadrelli, Scott, Saadallah Ramadan   +7 more
core   +1 more source