Results 21 to 30 of about 32,147 (209)

Detection of Bacterial α-l-Fucosidases with an Ortho-Quinone Methide-Based Probe and Mapping of the Probe-Protein Adducts

Molecules, 2022
Fucosidases are associated with several pathological conditions and play an important role in the health of the human gut. For example, fucosidases have been shown to be indicators and/or involved in hepatocellular carcinoma, breast cancer, and ...
Yvette M. C. A. Luijkx, Anniek J. Henselijn, Gerlof P. Bosman, Dario A. T. Cramer, Koen C. A. P. Giesbers, Esther M. van ‘t Veld, Geert-Jan Boons, Albert J. R. Heck, Karli R. Reiding, Karin Strijbis, Tom Wennekes   +10 more
doaj   +1 more source

Biological functions of fucose in mammals [PDF]

Glycobiology, 2017
Fucose is a 6-deoxy hexose in the l-configuration found in a large variety of different organisms. In mammals, fucose is incorporated into N-glycans, O-glycans and glycolipids by 13 fucosyltransferases, all of which utilize the nucleotide-charged form, GDP-fucose, to modify targets. Three of the fucosyltransferases, FUT8, FUT12/POFUT1 and FUT13/POFUT2,
Michael, Schneider, Esam, Al-Shareffi, Robert S, Haltiwanger   +2 more
openaire   +2 more sources

Incorporation of fucose into glycans independent of the GDP-fucose transporter SLC35C1 preferentially utilizes salvaged over de novo GDP-fucose

Journal of Biological Chemistry, 2022
Mutations in the SLC35C1 gene encoding the Golgi GDP-fucose transporter are known to cause leukocyte adhesion deficiency II. However, improvement of fucosylation in leukocyte adhesion deficiency II patients treated with exogenous fucose suggests the existence of an SLC35C1-independent route of GDP-fucose transport, which remains a mystery.
Edyta Skurska, Bożena Szulc, Dorota Maszczak-Seneczko, Maciej Wiktor, Wojciech Wiertelak, Aleksandra Makowiecka, Mariusz Olczak   +6 more
openaire   +2 more sources

Fucose, placental evolution and the glycocode [PDF]

Glycobiology, 2011
A family of 13 fucosyltransferase genes has evolved to catalyze the addition of fucose in various linkage positions to nascent glycoproteins. Null mutations in mice are unearthing unsuspected functions for glycoprotein fucosylation that affect embryo implantation and growth of the conceptus.
Aplin, JD; id_orcid 0000-0001-8777-9261, Jones, CJ   +1 more
openaire   +4 more sources

Correlation of serum levo-fucose levels as a biomarker with tumor node metastasis staging in oral cancer patients

Journal of Pharmacy and Bioallied Sciences, 2016
Background: oral cancer is a result of disordered cellular behavior initiated by various stimuli which is characterized by the alteration of serum glycoproteins consisting of different monosaccharides.
P Redwin Dhas Manchil, E Tatu Joy, M Shashi Kiran, J Eugenia Sherubin, M Farakath Khan, B S Aravind   +5 more
doaj   +1 more source

Beneficial effects of tyrosol on altered glycoprotein components in streptozotocin-induced diabetic rats

Pharmaceutical Biology, 2017
Context: Olive oil is the major source of tyrosol which is a natural phenolic antioxidant. Olive oil constitutes a major component of the Mediterranean diet that is linked to a reduced incidence of chronic diseases.
Ramasamy Chandramohan, Settu Saravanan, Leelavinothan Pari   +2 more
doaj   +1 more source

Comparative Analysis of L-Fucose Utilization and Its Impact on Growth and Survival of Campylobacter Isolates

Frontiers in Microbiology, 2022
Campylobacter jejuni and Campylobacter coli were previously considered asaccharolytic, but are now known to possess specific saccharide metabolization pathways, including L-fucose.
Pjotr S. Middendorf, Pjotr S. Middendorf, Wilma F. Jacobs-Reitsma, Aldert L. Zomer, Aldert L. Zomer, Heidy M. W. den Besten, Tjakko Abee   +6 more
doaj   +1 more source

Modulation of Morphology and Glycan Composition of Mucins in Farmed Guinea Fowl (Numida meleagris) Intestine by the Multi-Strain Probiotic Slab51^®

Animals, 2021
Probiotics have become highly recognized as supplements for poultry.Since gut health can be considered synonymous withanimal health, the effects of probiotic Slab51® on the morphology and the glycan composition of guineafowlintestine were examined.
Salvatore Desantis, Livio Galosi, Nicoletta Santamaria, Alessandra Roncarati, Lucia Biagini, Giacomo Rossi   +5 more
doaj   +1 more source

Up regulation of serum L fucose glycoprotein as a diagnostic biomarker for dysplasia in oral sub mucous fibrosis patients

Heliyon
Glycoproteins, essential for cellular functions, contain monosaccharides like Levo-fucose, crucial for cell communication. Recent research highlights serum L-fucose as a potential biomarker for early detection of malignancies.
Sunil Kumar Vaddamanu, Ravinder S. Saini, Bhavana T. Veerabasavaiah, Fahad Hussain Alhamoudi, AbdulKhaliq Ali F Alshadidi, Antonino Lo Giudice, Marco Cicciù, Giuseppe Minervini   +7 more
doaj   +1 more source

Challenges in the enantioanalysis of fucose using stochastic and potentiometric microsensors

Sensing and Bio-Sensing Research, 2014
Fucose gained significant interest in the medical field since a large number of studies have been reported on the role of fucose – as tumor marker. Electrochemical enantioselective sensors based on monocrystalline diamond paste and carbon paste working ...
Iuliana Moldoveanu, Raluca-Ioana Stefan-van Staden, Constantina P. Kapnissi-Cristodoulou, Jacobus Frederick van Staden, Hassan Y. Aboul-Enein   +4 more
doaj   +1 more source