Results 11 to 20 of about 32,147 (209)

Metabolomic and Transcriptomic Analyses of Escherichia coli for Efficient Fermentation of L-Fucose

Marine Drugs, 2019
L-Fucose, one of the major monomeric sugars in brown algae, possesses high potential for use in the large-scale production of bio-based products. Although fucose catabolic pathways have been enzymatically evaluated, the effects of fucose as a carbon ...
Jungyeon Kim, Yu Eun Cheong, Inho Jung, Kyoung Heon Kim   +3 more
doaj   +1 more source

The Threonine That Carries Fucose, but Not Fucose, Is Required for Cripto to Facilitate Nodal Signaling [PDF]

Journal of Biological Chemistry, 2007
Cripto is a membrane-bound co-receptor for Nodal, a member of the transforming growth factor-beta superfamily. Mouse embryos lacking either Cripto or Nodal have the same lethal phenotype at embryonic day 7.5. Previous studies suggest that O-fucosylation of the epidermal growth factor-like (EGF) repeat in Cripto is essential for the facilitation of ...
Shaolin, Shi, Changhui, Ge, Yi, Luo, Xinghua, Hou, Robert S, Haltiwanger, Pamela, Stanley   +5 more
openaire   +2 more sources

Assessment of serum fucose level among oral squamous cell carcinoma patients: A case-control study

Journal of Pharmacy and Bioallied Sciences, 2023
Background: Serum glycoproteins, which are made up of various monosaccharides, are altered in malignancy, a disorder of cellular conduct. L-fucose, a methyl pentose that serves as the last sugar in the majority of plasma glycoproteins, is one of the ...
Albert Ashem, Dhaval N Mehta, Deepak N Singh, Khwairakpam C Singh, Ch Anupriya, Ahanthem N Devi   +5 more
doaj   +1 more source

The Pseudomonas aeruginosa Lectin LecB Causes Integrin Internalization and Inhibits Epithelial Wound Healing

mBio, 2020
The opportunistic bacterium Pseudomonas aeruginosa produces the fucose-specific lectin LecB, which has been identified as a virulence factor. LecB has a tetrameric structure with four opposing binding sites and has been shown to act as a cross-linker ...
Roland Thuenauer, Alessia Landi, Anne Trefzer, Silke Altmann, Sarah Wehrum, Thorsten Eierhoff, Britta Diedrich, Jörn Dengjel, Alexander Nyström, Anne Imberty, Winfried Römer   +10 more
doaj   +1 more source

The fucose salvage pathway inhibits invadopodia formation and extracellular matrix degradation in melanoma cells.

PLoS ONE, 2018
The fucose salvage pathway is a two-step process in which mammalian cells transform L-fucose into GDP-L-fucose, a universal fucose donor used by fucosyltransferases to modify glycans.
Tyler Keeley, Shengchen Lin, Daniel K Lester, Eric K Lau, Shengyu Yang   +4 more
doaj   +1 more source

Increased Antibody Response to Fucosylated Oligosaccharides and Fucose-Carrying Bacteroides Species in Crohn’s Disease

Frontiers in Microbiology, 2020
Inflammatory bowel disease is associated with intestinal dysbiosis and with elevated antibody production toward microbial epitopes. The underlying processes linking the gut microbiota with inflammation are still unclear.
Katharina Kappler, Yi Lasanajak, David F. Smith, Lennart Opitz, Thierry Hennet   +4 more
doaj   +1 more source

Fucose as a potential therapeutic molecule against the immune-mediated inflammation in IgA nepharopathy: An unrevealed link

Frontiers in Immunology, 2022
BackgroundIgA nephropathy (IgAN) is an autoimmune disease that affects people of any age and is an important cause of end-stage renal disease. However, the pathogenesis and pathophysiology of IgAN is not clear.
Jianbo Qing, Jianbo Qing, Xueli Hu, Changqun Li, Wenzhu Song, Hasna Tirichen, Hasnaa Yaigoub, Yafeng Li, Yafeng Li, Yafeng Li, Yafeng Li   +10 more
doaj   +1 more source

Fucose-Containing Sulfated Polysaccharides from Brown Seaweeds Inhibit Proliferation of Melanoma Cells and Induce Apoptosis by Activation of Caspase-3 in Vitro

Marine Drugs, 2011
Fucose-containing sulfated polysaccharides (FCSPs) extracted from seaweeds, especially brown macro-algae, are known to possess essential bioactive properties, notably growth inhibitory effects on tumor cells.
Anne S. Meyer, Jørn D. Mikkelsen, Marcel Tutor Ale, Hidekazu Tamauchi, Hiroko Maruyama   +4 more
doaj   +1 more source

In Silico and In Vitro Investigation of the Distribution and Expression of Key Genes in the Fucose Operon of Escherichia coli

Microorganisms, 2023
Many gut bacteria degrade polysaccharides, providing nutritional advantages to their hosts. Fucose, a mucin degradation product, was suggested as a communication molecule between the resident microbiota and external pathogens.
Nehal A. Saif, Yomna A. Hashem, Heba M. Amin, Ramy K. Aziz   +3 more
doaj   +1 more source

A Comprehensive 19F NMR Framework for Fragment‐Based Drug Discovery: The Validated Screening Library OpenFL600 and Efficient Affinity Ranking by CSAR

Angewandte Chemie, EarlyView.
NMR screening is a powerful method for hit detection in drug‐discovery. We designed and validated the OpenFL600 19F$^{19}{\rm F}$ NMR library to probe diverse targets, including RNA, GPCRs, kinases, and proteases. This library yields target‐specific ligands without generating promiscuous binders.
Simon H. Rüdisser, Gabriela Stadler, Giacomo Padroni, Daria Barbash, Marco M. Ruckstuhl, Nils Lorz, Christina Jordan, Sarah Skibinski, Timo T. Stühlinger, Sarah E. Kratzwald, Katharina M. Siess, Sven Brüschweiler, Gerald Platzer, Antoine Cléry, Robert Konrat, Frédéric H.‐.T. Allain, Alvar D. Gossert   +16 more
wiley   +2 more sources