Core Fucosylation Represses SMURF1‐Dependent Degradation of CD47 to Promote Tumor Immune Evasion
Advanced Science, EarlyView.FUT8‐mediated core fucosylation of CD47 at N111 blocks SMURF1 binding and reduces CD47 ubiquitination and degradation. Blocking N111 glycosylation reduces CD47 expression and promotes macrophage phagocytosis of tumor cells. Furthermore, ablating CD47 core fucosylation boosts CD103+ dendritic cells (DCs) infiltration, increases natural killer (NK) cell ...
Yuting Cao +8 more
wiley +1 more source
Metabolomic profiles are gender, disease and time specific in the interleukin-10 gene-deficient mouse model of inflammatory bowel disease. [PDF]
, 2013 Metabolomic profiling can be used to study disease-induced changes in inflammatory bowel diseases (IBD). The aim of this study was to investigate the difference in the metabolomic profile of males and females as they developed IBD.
Churchill, Thomas A +6 more
core +2 more sources
Structure of the fucose mutarotase fromStreptococcus pneumoniaein complex with
Acta Crystallographica Section F Structural Biology and Crystallization Communications, 2011 Streptococcus pneumoniaerelies on a variety of carbohydrate-utilization pathways for both colonization of its human host and full virulence during the development of invasive disease. One such pathway is the fucose-utilization pathway, a component of which is fucose mutarotase (SpFcsU), an enzyme that performs the interconversion between α-L-fucose and
Melanie A, Higgins, Alisdair B, Boraston
openaire +2 more sources
Innenrücktitelbild: Fucose Binding Motifs on Mucin Core Glycopeptides Impact Bacterial Lectin Recognition (Angew. Chem. 32/2023) [PDF]
, 2023 Sandra Behren +7 more
openalex +1 more source
American Journal of Hematology, EarlyView.A novel erythropoietin (EPO) promoter mutation (c.‐136 G>A) causes autosomal dominant erythrocytosis via non‐renal expression of EPO. ABSTRACT We previously reported a five‐generation kindred with autosomal dominant erythrocytosis associated with a novel germline promoter variant in the erythropoietin (EPO) gene (EPO c.‐136 G>A).
Lucie Lanikova +10 more
wiley +1 more source
Frontiers in Nutrition, 2020 Human milk oligosaccharides (HMOs) enrich beneficial bifidobacteria in the infant gut microbiome which produce molecules that impact development and physiology.
Liv R. Dedon +5 more
doaj +1 more source
Frontiers in Microbiology, 2022 Campylobacter jejuni and Campylobacter coli were previously considered asaccharolytic, but are now known to possess specific saccharide metabolization pathways, including L-fucose.
Pjotr S. Middendorf +6 more
doaj +1 more source
A spectrophotometric study of the behavior of carbohydrates in seventy-nine per cent sulfuric acid [PDF]
, 1949 The spectral characteristics of solutions of eighteen representative monosaccharides in 79 per cent sulfuric acid have been determined for solutions maintained for 2 hours at 25° and 15 minutes at 100°.
Ikawa, Miyoshi, Niemann, Carl
core
Comparative Genomics of Campylobacter fetus from Reptiles and Mammals Reveals Divergent Evolution in Host-Associated Lineages [PDF]
, 2016 Acknowledgments The authors like to thank Brian Brooks and John Devenish (Canadian Food Inspection Agency) for providing strains and valuable suggestions.Peer reviewedPublisher ...
Duim, Birgitta +10 more
core +2 more sources
Genetic Basis for \u3cem\u3eRhizobium etli\u3c/em\u3e CE3 O-Antigen O-Methylated Residues That Vary According to Growth Conditions [PDF]
, 2010 The Rhizobium etli CE3 O antigen is a fixed-length heteropolymer with O methylation being the predominant type of sugar modification. There are two O-methylated residues that occur, on average, once per complete O antigen: a multiply O-methylated ...
Box, Jodie M. +2 more
core +1 more source