Results 171 to 180 of about 1,579 (190)
Some of the next articles are maybe not open access.

Separation, purification, structures and anticoagulant activities of fucosylated chondroitin sulfates from Holothuria scabra

International Journal of Biological Macromolecules, 2018
In this study, a new fucosylated chondroitin sulfate (HsG) with an average molecular weight of 69.1 kDa was isolated from sea cucumber Holothuria scabra. We investigated the structure of the HsG by adopting monosaccharide composition analysis, disaccharide composition analysis, IR,1H and13C NMR spectra and methylation analysis. According to methylation
Liu, Yang   +3 more
openaire   +2 more sources

Oral Absorption and Clearance of Partially Depolymerized Fucosyl Chondroitin Sulfate from Sea Cucumber

Thrombosis Research, 1999
Partially depolymerized holothurian glycosaminoglycan (DHG), a fucosyl chondroitin sulfate chains isolated from sea cucumber, was administered by the intravenous and oral routes to experimental animal. After intravenous injection, clearance of DHG, as measured by the postcolumn HPLC, displayed complex kinetics that were not dose dependent.
T, Imanari   +5 more
openaire   +2 more sources

Synthesis of Fucosylated Chondroitin Sulfate Glycoclusters: A Robust Route to New Anticoagulant Agents

Chemistry – A European Journal, 2017
AbstractFucosylated chondroitin sulfate (FuCS) is a structurally distinct glycosaminoglycan with excellent anticoagulant activity. Studies show that FuCS and its depolymerized fragments exhibit a different anticoagulant mechanism from that of heparin derivatives, with decreased risks of adverse effects and bleeding.
Xiao, Zhang   +7 more
openaire   +2 more sources

Antithrombotic activities of fucosylated chondroitin sulfates and their depolymerized fragments from two sea cucumbers

Carbohydrate Polymers, 2016
Fucosylated chondroitin sulfate (FCS), a glycosaminoglycan extracted from the body wall of sea cucumber, is a promising antithrombotic agent. The chemical structures of FCSc isolated from sea cucumber Cucumaria frondosa and its depolymerized fragment (dFCSc) were characterized for the first time.
Xiaoxiao Liu   +9 more
openaire   +2 more sources

Structural characterization of fucosylated chondroitin sulfates from sea cucumbers Apostichopus japonicus and Actinopyga mauritiana

Carbohydrate Polymers, 2016
Two samples of fucosylated chondroitin sulfate (FCS), AJ and AM, were isolated from holothurian species Apostichopus japonicus and Actinopyga mauritiana, respectively. Purification of FCS was performed by ion exchange chromatography followed by gel filtration.
Nadezhda E, Ustyuzhanina   +7 more
openaire   +2 more sources

Fucosylated chondroitin sulfate, an intriguing polysaccharide from sea cucumber: past, present, and future

Glycobiology
Abstract Fucosylated chondroitin sulfate (FCS) is a unique polysaccharide, first described nearly four decades ago, and found exclusively in sea cucumbers. It is a component of the extracellular matrix, possibly associated with peculiar properties of the invertebrate tissue.
Adriani L, Felix   +3 more
openaire   +2 more sources

Synthesis of Fucosylated Chondroitin Sulfate Nonasaccharide as a Novel Anticoagulant Targeting Intrinsic Factor Xase Complex

Angewandte Chemie - International Edition, 2018
Lisha Lin, Jinhua Zhao, Mingyi Wu
exaly  

Home - About - Disclaimer - Privacy