Results 161 to 170 of about 1,579 (190)

Synthesis and anticoagulation studies of “short-armed” fucosylated chondroitin sulfate glycoclusters

Carbohydrate Research, 2018
Fucosylated chondroitin sulfate (FuCS) is a structurally complex glycosaminoglycan found in sea cucumbers with a wide spectrum of biological activities, among which anticoagulant activity is particularly attractive for the development of alternative anticoagulant drugs with decreased adverse effects and risks of bleeding.
Huiying, Liu, Xiao, Zhang, Mingyi, Wu, Zhongjun, Li   +3 more
openaire   +2 more sources

Modulating the degree of fucosylation of fucosylated chondroitin sulfate enhances heparin cofactor II-dependent thrombin inhibition

European Journal of Medicinal Chemistry, 2018
Fucosylated chondroitin sulfate (FCS), an unusual glycosaminoglycan with fucose side chains, is a promising anticoagulant agent. To assess the effect of its structure on anticoagulant activity, its derivatives with various degrees of fucosylation (DF), molecular weights (Mw) and sulfation patterns were prepared and characterized.
Li Xu, Na Gao, Chuang Xiao, Lisha Lin, Steven W. Purcell, Mingyi Wu, Jinhua Zhao   +6 more
openaire   +3 more sources

Structural analysis of holothurian fucosylated chondroitin sulfates: Degradation versus non-destructive approach

Carbohydrate Research, 2019
Fucosylated chondroitin sulfates (FCS) are unique glycosaminoglycans isolated from the body walls of sea cucumbers (holothuria). These biopolymers are composed of a chondroitin core [→4)-β-d-GlcA-(1 → 3)-β-d-GalNAc-(1→]n bearing fucosyl branches and the sulfate groups. Fucosyl substituents prevent enzymatic degradations of FCS by chondroitinases, which
Nadezhda E, Ustyuzhanina, Maria I, Bilan, Nikolay E, Nifantiev, Anatolii I, Usov   +3 more
openaire   +2 more sources

High affinity of a fucosylated chondroitin sulfate for plasma low density lipoprotein

Atherosclerosis, 1996
Factors that influence the binding of sulfated polysaccharides to plasma low density lipoprotein (LDL) were investigated. Among the naturally occurring polysaccharides tested, a fucosylated chondroitin sulfate from an echinoderm exhibited the strongest interaction with LDL. Defucosylation and desulfation totally abolished the interaction with LDL while
A M, Tovar, P A, Mourão
openaire   +2 more sources

Fucosylated chondroitin sulfates from the sea cucumbers Holothuria tubulosa and Holothuria stellati

Carbohydrate Polymers, 2018
Two polysaccharides HT and HS were isolated from the sea cucumbers Holothuria tubulosa and Holothuria stellati, respectively. Purification of the natural polymers was performed by consecutive ion-exchange and gel permeation chromatography. The molar ratio of the monosaccharides and sulfate GlcA:GalNAc:Fuc:SO3Na was determined as 12:14:17:57 for HT and ...
Nadezhda E. Ustyuzhanina, Maria I. Bilan, Andrey S. Dmitrenok, Nikolay E. Nifantiev, Anatolii I. Usov   +4 more
openaire   +2 more sources

Two different fucosylated chondroitin sulfates: Structural elucidation, stimulating hematopoiesis and immune-enhancing effects

Carbohydrate Polymers, 2020
Two fucosylated chondroitin sulfates FCShp and FCSht were isolated from the sea cucumber Holothuria polii and Holothuria tubulosa, respectively. The NMR spectroscopy and HILIC-FTMS methods were applied for their detailed structural characterization. Chemical analysis indicated that the two FCSs all contained a chondroitin sulfate backbone chondroitin ...
Qingfeng Niu, Guoyun Li, Chao Li, Qinying Li, Jia Li, Chanjuan Liu, Lin Pan, Shijie Li, Chao Cai, JieJie Hao, Guangli Yu   +10 more
openaire   +2 more sources

Effects of oversulfated and fucosylated chondroitin sulfates on coagulation

Thrombosis and Haemostasis, 2010
SummaryWe report the effects of a chemically oversulfated chondroitin sulfate and a naturally fucosylated chondroitin sulfate on the coagulation system. The former has been recently identified as a contaminant of heparin preparations and the latter has been proposed as an alternative anticoagulant.
Roberto J C, Fonseca, Stephan-Nicollas M C G, Oliveira, Vitor H, Pomin, André S, Mecawi, Iracema G, Araujo, Paulo A S, Mourão   +5 more
openaire   +2 more sources

New insight on the structural diversity of holothurian fucosylated chondroitin sulfates

Pure and Applied Chemistry, 2019
Abstract Fucosylated chondroitin sulfates (FCS) are unique glycosaminoglycans isolated from body walls of sea cucumbers (holothuria). These biopolymers are composed of a chondroitin core [→4)-β-D-GlcA-(1→3)-β-D-GalNAc-(1→]n bearing fucosyl branches and sulfate groups.
Nadezhda E. Ustyuzhanina, Maria I. Bilan, Nikolay E. Nifantiev, Anatolii I. Usov   +3 more
openaire   +1 more source

Anti-enterovirus 71 activity of native fucosylated chondroitin sulfates and their derivatives

Carbohydrate Polymers
Enterovirus 71 (EV71) is recognized as a major causative agent of hand, foot, and mouth disease (HFMD), posing a significant global public health concern due to its widespread impact and resulting in a major public health issue worldwide. Despite its prevalence, current clinical therapy lacks effective antiviral agents. Fucosylated chondroitin sulfates
Qingfeng, Niu, Han, Zhou, Xiaoyao, Ma, Yuanyuan, Jiang, Chanjuan, Liu, Wei, Wang, Guangli, Yu, Guoyun, Li   +7 more
openaire   +2 more sources

Highly purified fucosylated chondroitin sulfate oligomers with selective intrinsic factor Xase complex inhibition

Carbohydrate Polymers, 2019
Fucosylated chondroitin sulfate (FCS) oligosaccharides of specific molecular weight have shown potent anticoagulant activities with selectivity towards intrinsic factor Xase complex. However, the preparation of FCS oligosaccharides by traditional methods requires multiple purification steps consuming large amounts of time and significant resources. The
Lufeng Yan, Danli Wang, Mengshan Zhu, Yanlei Yu, Fuming Zhang, Xingqian Ye, Robert J. Linhardt, Shiguo Chen   +7 more
openaire   +2 more sources