Results 161 to 170 of about 13,321 (212)

Chemical Fucosylation of a Polysaccharide: A Semisynthetic Access to Fucosylated Chondroitin Sulfate

Biomacromolecules, 2015
Chemical O-glycosylation of polysaccharides is an almost unexplored reaction. This is mainly due to the difficulties in derivatizing such complex biomacromolecules in a quantitative manner and with a fine control of the obtained structural parameters.
LAEZZA, ANTONIO, IADONISI, ALFONSO, DE CASTRO, CRISTINA, Mario De Rosa, Chiara Schiraldi, PARRILLI, MICHELANGELO, BEDINI, EMILIANO   +6 more
openaire   +5 more sources

Bacterial and host fucosylation maintain IgA homeostasis to limit intestinal inflammation in mice

Nature Microbiology
Inflammatory bowel disease is associated with several genetic risk loci. Loss-of-function mutation in the α1,2-fucosyltransferase (fut2) gene, which alters fucosylation on the surface of intestinal epithelial cells, is one example.
C. Lei, Chao Luo, Zhishan Xu, S. Ding, M. Sriwastva, Gerald W. Dryden, Ting Wang, Manman Xu, Yi Tan, Qilong Wang, Xiaozhong Yang, C. McClain, Zhongbin Deng   +12 more
semanticscholar   +1 more source

Fucosylation Required

Science's STKE, 2001
Glycosylation of proteins by the addition of O -linked fucose is rare and, so far, has been reported only for proteins containing an epidermal growth factor (EGF)-like domain. Schiffer et al. showed that the human EGF-CFC protein cripto, which has an EGF-like domain and a cysteine-rich domain,
openaire   +2 more sources

L-Fucose increases the fucosylation of colorectal cancer cells via promoting the accumulation of serine.

Food & Function, 2023
Fucosylation, a kind of posttranslational modification, has been identified as a key regulator of health, with alterations in this process serving as an indicator of diseases such as colorectal cancer.
Ye Yao, Chengjia Qian, Zepeng Chang, Jiayu Yang, Yinghan Chen, Hongchao Wang, Jinlin Zhu, Yue Xiao, Yahui Li, Jianxin Zhao, Wenwei Lu   +10 more
semanticscholar   +1 more source

Kiwifruit Polysaccharides Alleviate Ulcerative Colitis via Regulating Gut Microbiota-Dependent Tryptophan Metabolism and Promoting Colon Fucosylation.

Journal of Agricultural and Food Chemistry
A previous study showed that kiwifruit polysaccharide (KFP) has benefits in relieving intestinal inflammation, while the underlying mechanism remains unresolved.
Yixiao Li, Yanhui Han, Xuejie Wang, Xingbin Yang, Daoyuan Ren   +4 more
semanticscholar   +1 more source

Fucosylation of glycoproteins and glycolipids: opposing roles in cholera intoxication

Nature Chemical Biology
Cholera toxin (CT) is the etiological agent of cholera. Here we report that multiple classes of fucosylated glycoconjugates function in CT binding and intoxication of intestinal epithelial cells.
Atossa C Ghorashi, A. Boucher, Stephanie A Archer-Hartmann, D. Zalem, Mehrnoush Taherzadeh Ghahfarrokhi, Nathan B. Murray, R. S. R. Konada, Xunzhi Zhang, Chao Xing, Susann Teneberg, Parastoo Azadi, U. Yrlid, Jennifer J. Kohler   +12 more
semanticscholar   +1 more source

Enzymatic Galactosylation and Fucosylation of Phenols

Nature, 1964
PHENOLIC β-D-glucopyranosides have been synthesized by incubating phenols with plant enzymes in the presence of uridine diphosphate glucose1–5. All attempts to form β-D-glucosides by the enzymatic transfer of D-glucose from ‘low-energy’ donors (such as disaccharides, α-D-glucose-1-phosphate and simple β-D-glucosides) have so far failed using higher ...
J B, PRIDHAM, K, WALLENFELS
openaire   +2 more sources

Fucosylation inhibitor 6-alkynylfucose enhances the ATRA-induced differentiation effect on acute promyelocytic leukemia cells.

Biochemical and Biophysical Research Communications - BBRC
For acute promyelocytic leukemia (APL), differentiation therapy with all-trans retinoic acid (ATRA) is well established. However, the narrow application and tolerance development of ATRA remain to be improved.
Susumu Suzuki, Jianwei Liu, Yuri Sato, Rikuto Miyake, Souma Suzuki, Yoko Okitsu, Tomohiko Fukuda, T. Isaji, Jianguo Gu, Shinichirou Takahashi   +9 more
semanticscholar   +1 more source

Occurrence of fucosylated and non-fucosylated xyloglucans in the cell walls of monocotyledons: An immunofluorescence study

Plant Physiology and Biochemistry, 2019
The xyloglucans of monocotyledons are known to vary in the abundance of fucosylated side chains, with most commelinid monocotyledons having xyloglucans with lower proportions than non-commelinid monocotyledons. In many commelinid species, and some non-commelinid species that have lower proportions of fucosylated side chains, these side chains have been
Maree Brennan, Diyana Fakharuzi, Philip J. Harris   +2 more
openaire   +3 more sources

Chemoenzymatic Labeling, Detection and Profiling of Core Fucosylation in Live Cells

Journal of the American Chemical Society
Core fucosylation, the attachment of an α-1,6-linked-fucose to the N-glycan core pentasaccharide, is an abundant protein modification that plays critical roles in various biological processes such as cell signaling, B cell development, antibody-dependent
Qian Zhu, Jean-Luc Chaubard, Didi Geng, Jiechen Shen, L. Ban, Sheldon T. Cheung, Fangyu Wei, Yating Liu, Haofan Sun, Angie D. Calderon, Wenbo Dong, Weijie Qin, Tiehai Li, L. Wen, Peng George Wang, Shisheng Sun, Wen Yi, L. Hsieh‐Wilson   +17 more
semanticscholar   +1 more source