α1,3Fucosyltransferase VI is expressed in HepG2 cells and codistributed with β1,4galactosyltransferase I in the Golgi apparatus and monensin-induced swollen vesicles [PDF]
, 2017 The major α1,3fucosyltransferase activity in plasma, liver, and kidney is related to fucosyltransferase VI which is encoded by the FUT6 gene. Here we demonstrate the presence of α1,3fucosyltransferase VI (α3-FucT VI) in the human HepG2 hepatoma cell line
Berger, Eric G. +3 more
core
Targeting fucosyltransferase FUT8 as a prospective therapeutic approach for DLBCL
OncogenesisDiffuse large B-cell lymphoma (DLBCL) is characterized by its aggressive nature and resistance to standard chemotherapy, necessitating the development of new therapeutic approaches.
Hao Xu +9 more
doaj +1 more source
IgG Fucosylation: An Emerging Key Player in the Treatment of Severe COVID-19
EngineeringProtein glycosylation is one of the most vital modifications. Understanding the role of protein glycosylation in coronavirus disease 2019 (COVID-19) is the key in elucidating its pathogenesis and developing therapeutic strategies.
Caiping Zhao +11 more
doaj +1 more source
Glycomic Analysis of Biomedically Important O-glycoconjugates
, 2011 It has been established that all cells carry an array of glycans attached to proteins and lipids that are crucial in the interaction between cells and the surrounding matrix. Proteins are mainly glycosylated on asparagines (N-glycosylation) and serine or
Ismail, Mohd Nazri, Ismail, Mohd Nazri
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Suppression of beta1,3galactosyltransferase beta3Gal-T5 in cancer cells reduces sialyl-Lewis a and enhances poly-N-acetyllactosamines and sialyl-Lewis x on O-glycans [PDF]
, 2004 We investigated the role of beta 3 Gal-T5, a member of the beta 1,3galactosyltransferase (beta 1,3Gal-T) family, in cancer-associated glycosylation, focusing on the expression of sialyl-Lewis a (sLea, the epitope of CA19.9 antigen), poly N ...
MARE L, TRINCHERA M.
core
Biological Research, 2011 The Notch signaling pathway plays an important role in development and physiology. In Drosophila, Notch is activated by its Delta or Serrate ligands, depending in part on the sugar modifications present in its extracellular domain. O-fucosyltransferase-1
Alvaro Glavic +2 more
doaj
Stronger inflammatory/cytotoxic T cell response in women identified by microarray analysis [PDF]
, 2008 Women develop chronic inflammatory autoimmune diseases like lupus more often than men. The mechanisms causing the increased susceptibility are incompletely understood, although estrogen is believed to contribute.
Anura Hewagama +4 more
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Reprograming of gut microbiome energy metabolism by the FUT2 Crohn's disease risk polymorphism. [PDF]
, 2014 Fucosyltransferase 2 (FUT2) is an enzyme that is responsible for the synthesis of the H antigen in body fluids and on the intestinal mucosa. The H antigen is an oligosaccharide moiety that acts as both an attachment site and carbon source for intestinal ...
Borneman, James +14 more
core
Polysaccharide-synthesizing Glycosyltransferases and Carbohydrate Binding Modules: the case of Starch Synthase III [PDF]
, 2013 Glycosyltransferases (GTs) are a ubiquitous group of enzymes that catalyze the transfer of sugar moieties from activated donor molecules to specific acceptor molecules, forming glycosidic bonds.
Busi, María Victoria +2 more
core +1 more source