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Genomic structure and promoter analysis of the human α 1,6-fucosyltransferase gene (FUT 8)

open access: yesGenomic structure and promoter analysis of the human α 1,6-fucosyltransferase gene (FUT 8)
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Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs)

open access: yesGlycoconjugate Journal, 2020
Recently, studies have shown that Fucosylation plays an important role in the invasion and metastatic process of CSLCs. Understanding the expression pattern of fucosyltransferase (FUT) genes may help to suggest better-targeted therapy strategies for esophageal squamous cell carcinoma (ESCC). The study aimed to address the expression pattern of FUT gene
Zahra Sadeghzadeh   +3 more
openaire   +3 more sources
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Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma

Surgery Today, 2020
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It is an aggressive malignancy associated with poor prognosis because of recurrence, metastasis, and treatment resistance. Aberrant glycosylation of cancer cells triggers their migration and invasion and is considered one of the most important prognostic cancer ...
Kazuhiro, Tada   +13 more
openaire   +2 more sources

Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases

Journal of the American Chemical Society, 2017
The core fucosylation of N-glycans on glycoproteins is catalyzed by fucosyltransferase 8 (FUT8) in mammalian cells and is involved in various biological functions, such as protein function, cancer progression, and postnatal development. The substrate specificity of FUT8 toward bi-antennary N-glycans has been reported, but it is unclear with regard to ...
Tzu-Hao Tseng   +6 more
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Childhood glaucoma in association with congenital disorder of glycosylation caused by mutations in fucosyltransferase 8

Journal of American Association for Pediatric Ophthalmology and Strabismus, 2019
A rare form of congenital disorder of glycosylation (CDG) was recently discovered in individuals with biallelic mutations in fucosyltransferase 8 (FUT8). The clinical characteristics of patients with FUT8-CDG include intrauterine growth retardation, feeding difficulties, hypotonia, microcephaly, seizures, short stature, developmental delay, and ...
Anna, Schweigert, Raymond G, Areaux
openaire   +2 more sources

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