Results 161 to 170 of about 7,198,263 (194)

Expression of Fucosyltransferase 8 Is Associated with an Unfavorable Clinical Outcome in Non-Small Cell Lung Cancers

Oncology, 2015
<b><i>Objecitive:</i></b> Fucosyltransferase 8 (FUT8), the only enzyme responsible for the core α1,6-fucosylation of asparagine-linked oligosaccharides of glycoproteins, is a vital enzyme in cancer development and progression.
Rio, Honma, Ichiro, Kinoshita, Eiji, Miyoshi, Utano, Tomaru, Yoshihiro, Matsuno, Yasushi, Shimizu, Satoshi, Takeuchi, Yuka, Kobayashi, Kichizo, Kaga, Naoyuki, Taniguchi, Hirotoshi, Dosaka-Akita   +10 more
openaire   +2 more sources

In Silico Evaluation of the Binding Site of Fucosyltransferase 8 and First Attempts to Synthesize an Inhibitor with Drug‐Like Properties

ChemBioChem, 2019
AbstractCore fucosylation of N‐glycans is catalyzed by fucosyltransferase 8 and is associated with various types of cancer. Most reported fucosyltransferase inhibitors contain non‐drug‐like features, such as charged groups. New starting points for the development of inhibitors of fucosyltransferase 8 using a fragment‐based strategy are presented ...
Claas Strecker, Melissa Baerenfaenger, Michaela Miehe, Edzard Spillner, Bernd Meyer   +4 more
openaire   +3 more sources

Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α

Atherosclerosis, 2019
Aberrant fucosylation, such as α-1,6 fucosylation catalyzed by fucosyltransferase 8 (Fut8), is associated with reduced cell migration and is responsible for cholesterol-enriched foam cell accumulation in the intima in the early stage of atherosclerosis.
Linmu Chen, Jun Zhang, Xi Yang, Yan Liu, Xiao Deng, Chao Yu   +5 more
openaire   +2 more sources

Knockout Mice of α1,6 Fucosyltransferase (Fut 8)

2009
The core fucosylation (α1,6-fucosylation) of glycoproteins is widely distributed in mammalian tissues, and is altered under pathological conditions. To investigate the physiological functions of the core fucose, we generated α1,6-fucosyltransferase (Fut8)-null mice and found that disruption of Fut8 induces severe growth retardation and death during ...
openaire   +1 more source

Expression of alpha 1,6-fucosyltransferase 8 in hepatitis B virus-related hepatocellular carcinoma influences tumour progression

Digestive and Liver Disease, 2013
Alpha 1,6-fucosyltransferase 8 expression was demonstrated to be enhanced during hepatocarcinogenesis.Our study aimed to find out the clinical significance and biological function of alpha 1,6-fucosyltransferase 8 in hepatitis B virus-related hepatocellular carcinoma.Alpha 1,6-fucosyltransferase 8 expression levels were determined in 52 pairs of ...
Jun, Ji, Xing, Gu, Meng, Fang, Yunpeng, Zhao, Changhong, Yi, Aihua, Wang, Chunfang, Gao   +6 more
openaire   +2 more sources

MicroRNA‐198‐5p inhibits the migration and invasion of non‐small lung cancer cells by targeting fucosyltransferase 8

Clinical and Experimental Pharmacology and Physiology, 2019
AbstractMicroRNA‐198‐5p (miR‐198‐5p) displays crucial roles in various cancers including non‐small cell lung cancer (NSCLC), but the underlying molecular mechanisms remain unclear. Fucosyltransferase 8 (FUT8) is associated with tumour metastasis and prognosis. In this study, we explored the expression of miR‐198‐5p and FUT8 in NSCLC patients.
Siyao Wang, Xin Zhang, Chunlu Yang, Shun Xu   +3 more
openaire   +2 more sources

Fucosyltransferase 8 regulates adult neurogenesis and cognition of mice by modulating the Itga6-PI3K/Akt signaling pathway

Science China Life Sciences
Fucosyltransferase 8 (Fut8) and core fucosylation play critical roles in regulating various biological processes, including immune response, signal transduction, proteasomal degradation, and energy metabolism. However, the function and underlying mechanism of Fut8 and core fucosylation in regulating adult neurogenesis remains unknown.
Hongfeng, Guo, Qihang, Sun, Xiaoli, Huang, Xiaohao, Wang, Feng, Zhang, Wenzheng, Qu, Jinling, Liu, Xuejun, Cheng, Qiang, Zhu, Wen, Yi, Qiang, Shu, Xuekun, Li   +11 more
openaire   +2 more sources

Identification of target proteins of N‐acetylglucosaminyl‐transferase V and fucosyltransferase 8 in human gastric tissues by glycomic approach

PROTEOMICS, 2004
AbstractTo understand better the mechanism underlying gastric cancer and search for potential markers for gastric cancer prognosis, the proteomic analysis of gastric cancer tissues was conducted using two‐dimensional gel electrophoresis and lectin blot, followed by electrospray ionization‐mass spectrometry.
Yong-Sam, Kim, Soo Young, Hwang, Sejeong, Oh, Hosung, Sohn, Hye-Yeon, Kang, Jeong-Hwa, Lee, Eun-Wie, Cho, Jin-Young, Kim, Jong Shin, Yoo, Nam-Soon, Kim, Cheorl-Ho, Kim, Eiji, Miyoshi, Naoyuki, Taniguchi, Jeong Heon, Ko   +13 more
openaire   +2 more sources

Fucosyltransferase 8 (FUT8) Polymorphism, Thr267Lys, Is Associated With Pulmonary Emphysem

Chest, 2011
Miki Yamada, Takeo Ishii, Shinobu Ikeda, Kozui Kida, Masaaki Muramatsu, Motoji Sawabe   +5 more
openaire   +1 more source

Fucosyltransferase 8. GDP-Fucose N-Glycan Core α6-Fucosyltransferase (FUT8)

2014
Hideyuki Ihara, Hiroki Tsukamoto, Jianguo Gu, Eiji Miyoshi, Naoyuki Taniguchi, Yoshitaka Ikeda   +5 more
openaire   +1 more source