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Advances in cancer research on FUT8 molecular mechanisms and clinical applications. [PDF]

Int J Surg
Ma Q, Liu Y, Fan Q, Zhu X, Yang D, Zhao Z.   +5 more
europepmc   +1 more source

Genomic structure and promoter analysis of the human α 1,6-fucosyltransferase gene (FUT 8)

Genomic structure and promoter analysis of the human α 1,6-fucosyltransferase gene (FUT 8)
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Activated p53 with histone deacetylase inhibitor enhances L-fucose-mediated drug delivery through induction of fucosyltransferase 8 expression in hepatocellular carcinoma cells

Activated p53 with histone deacetylase inhibitor enhances L-fucose-mediated drug delivery through induction of fucosyltransferase 8 expression in hepatocellular carcinoma cells
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Upregulation of Fucosyltransferase 3, 8 and protein O-Fucosyltransferase 1, 2 genes in esophageal cancer stem-like cells (CSLCs)

Glycoconjugate Journal, 2020
Recently, studies have shown that Fucosylation plays an important role in the invasion and metastatic process of CSLCs. Understanding the expression pattern of fucosyltransferase (FUT) genes may help to suggest better-targeted therapy strategies for esophageal squamous cell carcinoma (ESCC). The study aimed to address the expression pattern of FUT gene
Zahra Sadeghzadeh, Ayyoob Khosravi, Marie Saghaeian Jazi, Jahanbakhsh Asadi   +3 more
openaire   +2 more sources

Substrate Preference and Interplay of Fucosyltransferase 8 and N-Acetylglucosaminyltransferases

Journal of the American Chemical Society, 2017
The core fucosylation of N-glycans on glycoproteins is catalyzed by fucosyltransferase 8 (FUT8) in mammalian cells and is involved in various biological functions, such as protein function, cancer progression, and postnatal development. The substrate specificity of FUT8 toward bi-antennary N-glycans has been reported, but it is unclear with regard to ...
Tzu-Hao Tseng, Tzu-Wen Lin, Chien-Yu Chen, Chein-Hung Chen, Jung-Lee Lin, Tsui-Ling Hsu, Chi-Huey Wong   +6 more
openaire   +2 more sources

Fucosyltransferase 8 plays a crucial role in the invasion and metastasis of pancreatic ductal adenocarcinoma

Surgery Today, 2020
Pancreatic ductal adenocarcinoma (PDAC) is the most common type of pancreatic cancer. It is an aggressive malignancy associated with poor prognosis because of recurrence, metastasis, and treatment resistance. Aberrant glycosylation of cancer cells triggers their migration and invasion and is considered one of the most important prognostic cancer ...
Kazuhiro, Tada, Masayuki, Ohta, Shinya, Hidano, Kiminori, Watanabe, Teijiro, Hirashita, Yusuke, Oshima, Atsuro, Fujnaga, Hiroaki, Nakanuma, Takashi, Masuda, Yuichi, Endo, Yu, Takeuchi, Yukio, Iwashita, Takashi, Kobayashi, Masafumi, Inomata   +13 more
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Childhood glaucoma in association with congenital disorder of glycosylation caused by mutations in fucosyltransferase 8

Journal of American Association for Pediatric Ophthalmology and Strabismus, 2019
A rare form of congenital disorder of glycosylation (CDG) was recently discovered in individuals with biallelic mutations in fucosyltransferase 8 (FUT8). The clinical characteristics of patients with FUT8-CDG include intrauterine growth retardation, feeding difficulties, hypotonia, microcephaly, seizures, short stature, developmental delay, and ...
Anna, Schweigert, Raymond G, Areaux
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Fucosyltransferase 8 deficiency suppresses breast cancer cell migration by interference of the FAK/integrin pathway

Cancer Biomarkers, 2019
BACKGROUND AND OBJECTIVE: Fucosyltranferase 8 (FUT8), which catalyzes core fucosylation of glycopeptides, plays important roles in cancer development. In this study, we aimed to explore the influence of FUT8 expression on migration ability of human breast cancer cells and its potential mechanisms.
Deshui, Liu, Zhiying, Gao, Liling, Yue
openaire   +2 more sources

Lysophosphatidic acid decreased macrophage foam cell migration correlated with downregulation of fucosyltransferase 8 via HNF1α

Atherosclerosis, 2019
Aberrant fucosylation, such as α-1,6 fucosylation catalyzed by fucosyltransferase 8 (Fut8), is associated with reduced cell migration and is responsible for cholesterol-enriched foam cell accumulation in the intima in the early stage of atherosclerosis.
Linmu Chen, Jun Zhang, Xi Yang, Yan Liu, Xiao Deng, Chao Yu   +5 more
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Expression of alpha 1,6-fucosyltransferase 8 in hepatitis B virus-related hepatocellular carcinoma influences tumour progression

Digestive and Liver Disease, 2013
Alpha 1,6-fucosyltransferase 8 expression was demonstrated to be enhanced during hepatocarcinogenesis.Our study aimed to find out the clinical significance and biological function of alpha 1,6-fucosyltransferase 8 in hepatitis B virus-related hepatocellular carcinoma.Alpha 1,6-fucosyltransferase 8 expression levels were determined in 52 pairs of ...
Jun, Ji, Xing, Gu, Meng, Fang, Yunpeng, Zhao, Changhong, Yi, Aihua, Wang, Chunfang, Gao   +6 more
openaire   +2 more sources