The contribution of fucosyltransferases to cancer biology [PDF]
Brazilian Journal of BiologyFucosyltransferases are enzymes that transfer L-fucose residues from a donor substrate to target molecules. These enzymes are encoded by genes known as FUTs (FUT1 to FUT-11), along with POFUT1 and 2.
A. O. Vasconcelos +3 more
doaj +2 more sources
Characterisation of FUT4 and FUT6 α-(1 → 2)-fucosyltransferases reveals that absence of root arabinogalactan fucosylation increases Arabidopsis root growth salt sensitivity. [PDF]
PLoS ONE, 2014 Plant type II arabinogalactan (AG) polysaccharides are attached to arabinogalactan proteins (AGPs) at hydroxyproline residues, and they are very diverse and heterogeneous structures.
Theodora Tryfona +5 more
doaj +9 more sources
Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation [PDF]
Genes and DiseasesFucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Caihan Duan +4 more
doaj +2 more sources
The ABC type fucose operon regulated by XtrSs through CcpA contributes to Streptococcus suis survival in macrophages [PDF]
VirulenceStreptococcus suis (S. suis), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and ...
Song Liang +8 more
doaj +2 more sources
Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages [PDF]
IMA Fungus, 2023 Fucose is a deoxyhexose sugar present and studied in mammals. The process of fucosylation has been the primary focus in studies relating to fucose in animals due to the presence of fucose in Lewis antigens.
Małgorzata Orłowska +3 more
doaj +2 more sources
Structure, function, and implications of fucosyltransferases in health and disease [PDF]
Nature CommunicationsFucosylation is a ubiquitous glycosylation event that shapes cellular communication and immunity. Catalyzed by fucosyltransferases (FUTs), this reaction encompasses diverse substrates, mechanisms, and biologic consequences. In this Review, we explore the
Mattia Ghirardello +5 more
doaj +2 more sources
Altered O-linked glycosylation in benign and malignant meningiomas [PDF]
PeerJBackground Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined.
Chutima Talabnin +7 more
doaj +3 more sources
FUT11-Driven fucosylation coordinates K63 ubiquitination of keratin 17 to sustain psoriatic keratinocytes hyperproliferation [PDF]
Cell Communication and SignalingBackground The pathogenesis of psoriasis is characterized by dysregulated post-translational modifications, with particular emphasis on fucosylation—a glycosylation process mediated by fucosyltransferases (FUTs).
Xia Li +8 more
doaj +2 more sources
Protein O-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals [PDF]
MoleculesDomain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage.
Huilin Hao +3 more
doaj +2 more sources
Structural basis for Lewis antigen synthesis by the α1,3-fucosyltransferase FUT9. [PDF]
Nat Chem Biol, 2023 Kadirvelraj R +11 more
europepmc +3 more sources