Acute and chronic lung inflammation drives changes in epithelial glycans. [PDF]
Front Immunol, 2023 IntroductionAsthma is the most common chronic inflammatory disease and it is characterized by leukocyte infiltration and tissue remodeling, with the latter generally referring to collagen deposition and epithelial hyperplasia.
Alvarez CA +5 more
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Fucosylation in digestive inflammatory diseases and cancers: From mechanical studies to clinical translation. [PDF]
Genes DisFucosylation is a post-translational modification that attaches fucose to glycoproteins or glycolipids, thereby influencing their biological functions. Consequently, fucosylation proves indispensable for many biological processes, such as ligand–receptor
Duan C, Wu J, Wang Z, Hou X, Han C.
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Characterisation of FUT4 and FUT6 α-(1 → 2)-fucosyltransferases reveals that absence of root arabinogalactan fucosylation increases Arabidopsis root growth salt sensitivity. [PDF]
PLoS ONE, 2014 Plant type II arabinogalactan (AG) polysaccharides are attached to arabinogalactan proteins (AGPs) at hydroxyproline residues, and they are very diverse and heterogeneous structures.
Theodora Tryfona +5 more
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Fucose as a nutrient ligand for Dikarya and a building block of early diverging lineages. [PDF]
IMA Fungus, 2023 Fucose is a deoxyhexose sugar present and studied in mammals. The process of fucosylation has been the primary focus in studies relating to fucose in animals due to the presence of fucose in Lewis antigens.
Orłowska M +3 more
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Altered O-linked glycosylation in benign and malignant meningiomas. [PDF]
PeerJBackground Changes in protein glycosylation have been reported in various diseases, including cancer; however, the consequences of altered glycosylation in meningiomas remains undefined.
Talabnin C +7 more
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The ABC type fucose operon regulated by XtrSs through CcpA contributes to <i>Streptococcus suis</i> survival in macrophages. [PDF]
VirulenceStreptococcus suis (S. suis), an important zoonotic pathogen, poses a huge threat to the pig industry and human health. The fucose operon (FCS) is found in many bacteria that utilize host glycosylation modifications, contributing to bacterial growth and ...
Liang S +8 more
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Protein <i>O</i>-Fucosyltransferases: Biological Functions and Molecular Mechanisms in Mammals. [PDF]
MoleculesDomain-specific O-fucosylation is an unusual type of glycosylation, where the fucose is directly attached to the serine or threonine residues in specific protein domains via an O-linkage.
Hao H +3 more
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FUT3 facilitates glucose metabolism of lung adenocarcinoma via activation of NF-κB pathway. [PDF]
BMC Pulm Med, 2023 Objective Fucosyltransferases (FUTs) molecules have been identified to be involved in carcinogenesis of malignant tumors. Nevertheless, the biological function of fucosyltransferases-3 (FUT3) in lung adenocarcinoma (LUAD) malignant phenotype remains ...
Lin L +5 more
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Comprehensive pan-cancer analysis of FUTs family as prognostic and immunity markers based on multi-omics data. [PDF]
Discov OncolBackground The dysregulation of fucosyltransferases (FUTs) contributes to alterations in fucosylated epitope expression, which serve as distinctive features of cancer cells. Nonetheless, a comprehensive elucidation of the prognostic biological marker and
Jia Z, Liao P, Yan B, Lei P.
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Viruses, 2023 Although rotavirus A (RVA) is the primary cause of acute viral gastroenteritis in children and young animals, mechanisms of its replication and pathogenesis remain poorly understood.
Molly Raque +5 more
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