Results 91 to 100 of about 5,422 (250)

Distinct Molecular Biomechanical Mechanisms Inhibit Endosperm Cell‐Wall Weakening and Seed Germination at Cold and Warm Nonoptimal Temperatures

Plant, Cell &Environment, EarlyView.
ABSTRACT Temperature sensing to adjust developmental rates and phenological responses to different climatic environments is critical for plant survival. Population‐based thermal‐time threshold models predict linear relationships between temperature and, for example, seed germination rates (speed), but the mechanisms are not known.
Tina Steinbrecher, Antje Voegele, Michael Ignatz, Karin Weitbrecht, Safina Khan, Kai Graeber, James E. Hourston, Gerhard Leubner‐Metzger   +7 more
wiley   +1 more source

Novel function of pregnancy-associated plasma protein A: promotes endometrium receptivity by up-regulating N-fucosylation

Scientific Reports, 2017
Glycosylation of uterine endometrial cells plays important roles to determine their receptive function to blastocysts. Trophoblast-derived pregnancy-associated plasma protein A (PAPPA) is specifically elevated in pregnant women serum, and is known to ...
Ming Yu, Jiao Wang, Shuai Liu, Xiaoqi Wang, Qiu Yan   +4 more
doaj   +1 more source

Predictive glycoengineering of biosimilars using a Markov chain glycosylation model [PDF]

, 2016
Biosimilar drugs must closely resemble the pharmacological attributes of innovator products to ensure safety and efficacy to obtain regulatory approval. Glycosylation is one critical quality attribute that must be matched, but it is inherently difficult ...
Hansen, Anders Holmgaard, Kol, Stefan, Lewis, Nathan E., Spahn, Philipp N., Voldborg, Bjørn Gunnar   +4 more
core   +1 more source

Characterization of blood group variants in an Omani population by comparison of whole genome sequencing and serology

Transfusion, EarlyView.
Abstract Background Although blood group variation was first described over a century ago, our understanding of the genetic variation affecting antigenic expression on the red blood cell surface in many populations is lacking. This deficit limits the ability to accurately type patients, especially as serological testing is not available for all ...
Paige E. Haffener, Arwa Z. Al‐Riyami, Shoaib Al‐Zadjali, Mohammed Al‐Rawahi, Saif Al Hosni, Ali Al Marhoobi, Ammar Al Sheriyani, Ellen M. Leffler   +7 more
wiley   +1 more source

Assessing DNA methylation in the developing human intestinal epithelium: potential link to inflammatory bowel disease. [PDF]

, 2015
DNA methylation is one of the major epigenetic mechanisms implicated in regulating cellular development and cell-type-specific gene expression. Here we performed simultaneous genome-wide DNA methylation and gene expression analysis on purified intestinal
Cario, E, Gasparetto, M, Heuschkel, R, Kraiczy, J, Mak, TN, Nayak, K, Raine, T, Rakyan, V, Ross, A, Zilbauer, M   +9 more
core   +1 more source

Multi‐omic data integration and exploiting metabolic models using systems biology approach increase precision in subtyping and early diagnosis of cancer

Quantitative Biology, Volume 13, Issue 4, December 2025.
Abstract Cancer is a complex and heterogeneous disease characterized by various genetic and epigenetic alterations. Early diagnosis, accurate subtyping, and staging are essential for effective, personalized treatment and improved survival rates. Traditional diagnostic methods, such as biopsies, are invasive and carry operational risks that hinder ...
Ezgi Tanıl, Emrah Nikerel
wiley   +1 more source

Starch-enriched diet modulates the glucidic profile in the rat colonic mucosa [PDF]

, 2017
Purpose. The protective function of the intestinal mucosa largely depends on carbohydrate moieties that as a part of glycoproteins and glycolipids form the epithelial glycocalyx or are secreted as mucins.
Gabrielli, Maria Gabriella, Tomassoni, Daniele   +1 more
core   +1 more source

A Surface Plasmon Resonance‐Based Integrated Assay for Quantification and Glycosylation Characterization of Monoclonal Antibodies in Crude Heterogeneous Samples

Biotechnology and Bioengineering, Volume 122, Issue 10, Page 2724-2738, October 2025.
ABSTRACT The rise in cancer, autoimmune, inflammatory, and infectious diseases in recent decades has led to a surge in the development of monoclonal antibodies (mAbs) therapies, now the most widely used family of biologics. To meet the growing global demand, biopharmaceutical industries are intensifying their production processes.
Ilona Metayer, Catherine Forest‐Nault, Julie Guimond, Simon Joubert, Olivier Henry, Yves Durocher, Gregory De Crescenzo, Jimmy Gaudreault   +7 more
wiley   +1 more source

Glycans and glycosaminoglycans in neurobiology: key regulators of neuronal cell function and fate [PDF]

, 2018
The aim of the present study was to examine the roles of l-fucose and the glycosaminoglycans (GAGs) keratan sulfate (KS) and chondroitin sulfate/dermatan sulfate (CS/DS) with selected functional molecules in neural tissues.
Hayes, Anthony J., Melrose, James
core   +2 more sources

Cell wall‐related glycosyltransferases and wall architecture in the model liverwort Marchantia polymorpha

The Plant Journal, Volume 123, Issue 5, September 2025.
SUMMARY The liverwort Marchantia polymorpha has emerged as an important plant model for developmental studies and may become central to elucidate the complex process of cell wall polysaccharide biosynthesis. This study comprehensively analyses the composition and structure of cell wall glycans across eight different M. polymorpha tissue types.
Hee Sung Kang, Xin Tong, Alban Mariette, Minnie Leong, Cherie Beahan, Eduardo Flores‐Sandoval, Gustav B. Pedersen, Carsten Rautengarten, John L. Bowman, Berit Ebert, Anthony Bacic, Monika S. Doblin, Staffan Persson, Edwin R. Lampugnani   +13 more
wiley   +1 more source